The weight of weights: Causal impact of overweight on major depressive disorder and its disparate association with suicide attempts in over 450,000 individuals of European ancestry (AM-SRNMA 003)

IF 3.5 2区 医学 Q2 PSYCHIATRY Journal of Psychosomatic Research Pub Date : 2024-07-14 DOI:10.1016/j.jpsychores.2024.111858
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Abstract

Aim

Some studies and societal discussions have suggested a potential link between overweight and a higher risk of mental disorders and suicidal ideation. However, the causal relationships between these factors remain unclear. This study aims to assess the bidirectional causal associations between overweight and mental disorders, including suicidal attempts.

Method

We conducted a Two-Sample Mendelian Randomization study utilizing data from over 450,000 individuals of European ancestry sourced from a comprehensive Genome-Wide Association Study database. We chose single-nucleotide polymorphisms as instrumental variables.

Results

Our analyses consistently supported a unidirectional causal association of overweight with the increased risk of major depressive disorder (MDD, β = 0.152, se = 0.069, P = 0.027), bipolar affective disorders (BD, β = 0.197, se = 0.092, P = 0.033), and attention-deficit / hyperactivity disorder (ADHD, β = 0.308, se = 0.080, P = 1.366 × 10−4). We observed no significant causal relationships for the exposure of overweight to anxiety disorder (AD), manic episode (MA), panic disorder (PD), schizophrenia (SZ), substance use disorder (SUD), autism spectrum disorder (ASD), ever attempted suicide, recent thoughts of suicide or self-harm, and suicide or other intentional self-harm events.

Conclusion

This study has provided evidence for the causal relationship between overweight and MDD, BD, ADHD, with no observed relationship between overweight and AD, MA, PD, SZ, SUD, ASD, ever attempted suicide, recent thoughts of suicide or self-harm, and suicide or other intentional self-harm events.

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体重的重量:超重对重度抑郁障碍的因果影响及其与超过 45 万欧洲血统的自杀企图的不同关联(AM-SRNMA 003)
目的一些研究和社会讨论表明,超重与较高的精神障碍和自杀意念风险之间存在潜在联系。然而,这些因素之间的因果关系仍不明确。本研究旨在评估超重与精神障碍(包括自杀企图)之间的双向因果关系。方法我们利用来自全基因组关联研究综合数据库的超过 45 万名欧洲血统个体的数据,开展了一项双样本孟德尔随机研究。结果我们的分析一致支持超重与重度抑郁障碍(MDD,β = 0.152,se = 0.069,P = 0.027)、双相情感障碍(BD,β = 0.197,se = 0.092,P = 0.033)和注意缺陷/多动障碍(ADHD,β = 0.308,se = 0.080,P = 1.366 × 10-4)的单向因果关系。我们观察到,超重与焦虑症(AD)、躁狂症(MA)、恐慌症(PD)、精神分裂症(SZ)、药物使用障碍(SUD)、自闭症谱系障碍(ASD)、曾经自杀未遂、最近有自杀或自残念头以及自杀或其他故意自残事件之间没有明显的因果关系。结论本研究为超重与 MDD、BD、ADHD 之间的因果关系提供了证据,但未观察到超重与 AD、MA、PD、SZ、SUD、ASD、曾试图自杀、最近有自杀或自残念头以及自杀或其他故意自残事件之间存在关系。
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来源期刊
Journal of Psychosomatic Research
Journal of Psychosomatic Research 医学-精神病学
CiteScore
7.40
自引率
6.40%
发文量
314
审稿时长
6.2 weeks
期刊介绍: The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.
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