Saccades, pupil response and blink abnormalities in Huntington’s disease patients during free viewing

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-06-29 DOI:10.1016/j.clinph.2024.06.012

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Abstract

Objective

Video-based eye tracking was used to investigate saccade, pupil, and blink abnormalities among patients with Huntington’s disease (HD) who watched sequences of short videos. HD, an autosomal dominant neurodegenerative disorder resulting from a CAG mutation on chromosome 4, produces motor and cognitive impairments including slow or irregular eye movements, which have been studied using structured tasks.

Methods

To explore how HD affects eye movements under instruction free conditions, we assessed 22 HD patients and their age matched controls in a 10-minute video-based free viewing task.

Results

Patients with HD experienced a significant reduction in saccade exploration rate following video clip transitions, an increase in pupil reactions to luminance changes after clip transitions, and a significant higher blink rate throughout the task compared to the control group.

Conclusions

These results show that HD has a significant impact on how patients visually explore and respond to their environment under unconstrained and ecologically natural conditions.

Significance

Eye tracking in HD patients revealed saccadic, pupil, and blink abnormalities in early HD patients, suggestive of brain circuitry abnormalities that probably involve brain stem deficits. Further research should explore the impact of these changes on the quality of life of the patients affected by the disease.

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亨廷顿氏病患者在自由观看时的视线移动、瞳孔反应和眨眼异常

目的通过基于视频的眼动跟踪研究亨廷顿氏病（HD）患者在观看短视频序列时的眼球运动、瞳孔和眨眼异常。HD是一种常染色体显性神经退行性疾病，由第4号染色体上的CAG突变引起，会产生运动和认知障碍，包括眼球运动缓慢或不规则，这些问题已通过结构化任务进行了研究。方法为了探索HD如何影响无指令条件下的眼球运动，我们对22名HD患者及其年龄匹配的对照组进行了10分钟的视频自由观看任务评估。结果与对照组相比，HD 患者在视频片段转换后的囊状移动探索率明显降低，片段转换后瞳孔对亮度变化的反应增加，整个任务过程中的眨眼率明显升高。这些结果表明，在无限制的生态自然条件下，HD 会对患者的视觉探索和对环境的反应产生重大影响。意义HD 患者的眼球追踪显示，早期 HD 患者的囊回、瞳孔和眨眼异常，提示大脑回路异常，可能涉及脑干缺陷。进一步的研究应探讨这些变化对该病患者生活质量的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.