{"title":"Quantitative elemental analysis of rat bone using micro-PIXE analysis","authors":"Yugo Kato , Haruko Yakumaru , Kyoko Ayama , Masakazu Oikawa , Shino Homma-Takeda","doi":"10.1016/j.nimb.2024.165473","DOIUrl":null,"url":null,"abstract":"<div><p>Hydroxyapatite (Ca<sub>5</sub>(PO<sub>4</sub>)<sub>3</sub>(OH)) is the main component of the bone, and the molar ratio of calcium and phosphorus (Ca/P) reflects the growth and health status of the bone. In this study, the micro particle-induced X-ray emission (micro-PIXE) was used to calculate local molar Ca/P ratios in different parts of rat bone. Linear calibration curve was obtained by measuring droplets containing increasing concentrations of Ca and P. It was used to calculate Ca and P concentration in three different areas (diaphysis, trabecula, and epiphysis area) of interest of the femoral bone. There were differences in Ca/P molar ratio in these three.</p></div>","PeriodicalId":19380,"journal":{"name":"Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms","volume":"555 ","pages":"Article 165473"},"PeriodicalIF":1.4000,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms","FirstCategoryId":"101","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0168583X2400243X","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INSTRUMENTS & INSTRUMENTATION","Score":null,"Total":0}
引用次数: 0
Abstract
Hydroxyapatite (Ca5(PO4)3(OH)) is the main component of the bone, and the molar ratio of calcium and phosphorus (Ca/P) reflects the growth and health status of the bone. In this study, the micro particle-induced X-ray emission (micro-PIXE) was used to calculate local molar Ca/P ratios in different parts of rat bone. Linear calibration curve was obtained by measuring droplets containing increasing concentrations of Ca and P. It was used to calculate Ca and P concentration in three different areas (diaphysis, trabecula, and epiphysis area) of interest of the femoral bone. There were differences in Ca/P molar ratio in these three.
期刊介绍：
Section B of Nuclear Instruments and Methods in Physics Research covers all aspects of the interaction of energetic beams with atoms, molecules and aggregate forms of matter. This includes ion beam analysis and ion beam modification of materials as well as basic data of importance for these studies. Topics of general interest include: atomic collisions in solids, particle channelling, all aspects of collision cascades, the modification of materials by energetic beams, ion implantation, irradiation - induced changes in materials, the physics and chemistry of beam interactions and the analysis of materials by all forms of energetic radiation. Modification by ion, laser and electron beams for the study of electronic materials, metals, ceramics, insulators, polymers and other important and new materials systems are included. Related studies, such as the application of ion beam analysis to biological, archaeological and geological samples as well as applications to solve problems in planetary science are also welcome. Energetic beams of interest include atomic and molecular ions, neutrons, positrons and muons, plasmas directed at surfaces, electron and photon beams, including laser treated surfaces and studies of solids by photon radiation from rotating anodes, synchrotrons, etc. In addition, the interaction between various forms of radiation and radiation-induced deposition processes are relevant.
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