{"title":"Optimization of Zwitterionic Polymers for Cell Cryopreservation","authors":"Yui Kato, Takuya Uto, Takeru Ishizaki, Daisuke Tanaka, Kojiro Ishibashi, Yuya Matsuda, Issei Onoda, Akiko Kobayashi, Masaharu Hazawa, Richard W. Wong, Kenji Takahashi, Eishu Hirata, Kosuke Kuroda","doi":"10.1002/mabi.202470016","DOIUrl":null,"url":null,"abstract":"<p><b>Front Cover</b>: In article 2300499, Kosuke Kuroda and co-workers optimize an isotonic freezing medium composed of poly(zwitterion), which alleviates osmotic shock unlike typical hypertonic freezing media. Imidazolium/carboxylate-type poly(zwitterion) is the optimal chemical structure. This illustration shows that the optimized poly(zwitterion) protects cells from ice crystal formation by forming a matrix around the cell membrane.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202470016","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular bioscience","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mabi.202470016","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Front Cover: In article 2300499, Kosuke Kuroda and co-workers optimize an isotonic freezing medium composed of poly(zwitterion), which alleviates osmotic shock unlike typical hypertonic freezing media. Imidazolium/carboxylate-type poly(zwitterion) is the optimal chemical structure. This illustration shows that the optimized poly(zwitterion) protects cells from ice crystal formation by forming a matrix around the cell membrane.
期刊介绍：
Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals.
Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers.
With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.
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