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PROTAC and Molecular Glue Degraders of the Oncogenic RNA Binding Protein Lin28. 致癌 RNA 结合蛋白 Lin28 的 PROTAC 和分子胶降解剂。
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-22 DOI: 10.1002/mabi.202400427
Aseel Kashkush, Judith Furth-Lavi, Jiri Hodon, Raphael I Benhamou

The interaction between proteins and RNA is crucial for regulating gene expression, with dysregulation often linked to diseases such as cancer. The RNA-binding protein (RBP) Lin28 inhibits the tumor suppressor microRNA (miRNA) let-7, making it a significant oncogenic factor in tumor progression and metastasis. In this study, a small molecule is used that binds Lin28 and blocks its inhibition of let-7. To enhance its efficay, the inhibitor is transformed into degraders via two degradation approaches: Proteolysis Targeting Chimera (PROTAC) and molecular glue. A series of PROTAC bifunctional molecules and molecular glues capable of degrading Lin28 in cells.is developed Both strategies significantly reduce overexpressed Lin28 and alleviate cancer cellular phenotypes. Notably, the molecular glue approach demonstrates exceptional potency, surpassing PROTAC in several aspects. This outcome underscores the superior efficiency of the molecular glue approach for targeted Lin28 degradation and highlights its potential for addressing associated diseases with small molecules. Innovative small molecule strategies such as molecular glue and PROTAC technology for targeted RBP degradation, hold promise for opening new avenues in RNA modulation and addressing related diseases.

蛋白质和 RNA 之间的相互作用对于调节基因表达至关重要,而基因表达失调往往与癌症等疾病有关。RNA结合蛋白(RBP)Lin28抑制肿瘤抑制因子microRNA(miRNA)let-7,使其成为肿瘤进展和转移的重要致癌因子。在这项研究中,使用了一种能结合 Lin28 并阻断其对 let-7 抑制作用的小分子。为了增强其效果,该抑制剂通过两种降解方法转化为降解剂:蛋白水解靶向嵌合体(PROTAC)和分子胶。这两种方法都能显著减少过表达的 Lin28 并减轻癌细胞表型。值得注意的是,分子胶方法表现出了非凡的效力,在多个方面超过了 PROTAC。这一结果凸显了分子胶水方法在靶向降解 Lin28 方面的卓越功效,并彰显了其利用小分子药物治疗相关疾病的潜力。创新的小分子策略,如分子胶和 PROTAC 技术用于靶向降解 RBP,有望为 RNA 调节和解决相关疾病开辟新途径。
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引用次数: 0
Sustained Drug Release from Dual-Responsive Hydrogels for Local Cancer Chemo-Photothermal Therapy. 用于局部癌症化疗-光热疗法的双反应水凝胶的持续药物释放。
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-20 DOI: 10.1002/mabi.202400413
Zhixiang Liu, Yoshitaka Koseki, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

As an exceptional carrier for localized drug delivery to tumors, hydrogels can achieve prolonged drug release through careful design and adjustments, effectively targeting cancer cells and minimizing side effects. This study investigates a novel dual-responsive hydrogel system designed for the delivery of nanomedicines, focusing on drug release and the local antitumor efficacy of SN-38-cholesterol nanoparticles (SN-38-chol NPs) and polydopamine NPs (PDA NPs)/poly(n-isopropylacrylamide) (pNIPAM) hydrogels. By combining the thermosensitive properties of pNIPAM with the near-infrared (NIR) responsiveness of PDA NPs, the hydrogel aims to enhance on-demand drug release. SN-38-chol NPs, known for their stability and small size, are incorporated into the hydrogel to improve drug release dynamics. The investigation reveals a drug release cycle of over three weeks, maintaining sensitivity to both temperature and NIR light for controlled drug release. In vivo studies demonstrate the high tumor growth inhibition performance of the system after photothermal treatment induced by 808 nm NIR light. These results suggest that the drug-carrying hydrogel system holds promise for diverse applications in chemical and physical therapies, including the treatment of malignant wounds, post-surgery wound healing, and direct tumor treatment. This study establishes the potential of SN-38-chol NPs and PDA NPs/pNIPAM hydrogels as effective platforms for chemo-phototherapy.

水凝胶是肿瘤局部给药的一种特殊载体,通过精心设计和调整,可实现药物的长时间释放,有效靶向癌细胞并将副作用降至最低。本研究探讨了一种新型双响应水凝胶系统,该系统设计用于纳米药物的递送,重点研究 SN-38-cholesterol 纳米粒子(SN-38-chol NPs)和聚多巴胺 NPs(PDA NPs)/聚(正异丙基丙烯酰胺)(pNIPAM)水凝胶的药物释放和局部抗肿瘤功效。这种水凝胶结合了 pNIPAM 的热敏特性和 PDA NPs 的近红外(NIR)响应性,旨在提高药物的按需释放。SN-38-chol NPs 以其稳定性和小尺寸而著称,被加入水凝胶中以改善药物释放动力学。研究表明,这种水凝胶的药物释放周期超过三周,对温度和近红外光都保持敏感,从而实现了药物的可控释放。体内研究表明,在 808 纳米近红外光的诱导下进行光热处理后,该系统对肿瘤生长有很强的抑制作用。这些结果表明,这种载药水凝胶系统有望在化学和物理疗法中得到广泛应用,包括治疗恶性伤口、手术后伤口愈合和直接治疗肿瘤。这项研究证实了 SN-38-chol NPs 和 PDA NPs/pNIPAM 水凝胶作为化疗光疗有效平台的潜力。
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引用次数: 0
Development of Mg-Alginate Based Self Disassociative Bio-Ink for Magnetic Bio-Patterning of 3D Tumor Models. 开发基于海藻酸镁的自解离生物墨水,用于三维肿瘤模型的磁性生物图案。
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-18 DOI: 10.1002/mabi.202400339
Basak Coban, Mehmet Baskurt, Hasan Sahin, Ahu Arslan-Yildiz

Alginate forms a hydrogel via physical cross-linking with divalent cations. In literature, Ca2+ is mostly utilized due to strong interactions but additional procedures are required to disassociate Ca-alginate hydrogels. On the other hand, Mg-alginate hydrogels disassociate spontaneously, which might benefit certain applications. This study introduces Mg-alginate as the main component of a bio-ink for the first time to obtain 3D tumor models by magnetic bio-patterning technique. The bio-ink contains magnetic nanoparticles (MNPs) for magnetic manipulation, Mg-alginate hydrogel as a sacrificial material, and cells. The applicability of the methodology is tested for the formation of 3D tumor models using HeLa, SaOS-2, and SH-SY5Y cells. Long-term cultures are examined by Live/dead and MTT analysis and revealed high cell viability. Subsequently, Collagen and F-actin expressions are observed successfully in 3D tumor models. Finally, the anti-cancer drug Doxorubicin (DOX) effect is investigated on 3D tumor models, and IC50 values is calculated to assess the drug response. As a result, significantly higher drug resistance is observed for bio-patterned 3D tumor models up to tenfold compared to 2D control. Overall, Mg-alginate hydrogel is successfully used to form bio-patterned 3D tumor models, and the applicability of the model is shown effectively, especially as a drug screening platform.

海藻酸盐通过与二价阳离子的物理交联形成水凝胶。在文献中,Ca2+ 因其强大的相互作用而被广泛使用,但要使 Ca-海藻酸盐水凝胶解离还需要额外的程序。另一方面,Mg-阿尔金酸盐水凝胶可自发解离,这可能有利于某些应用。本研究首次将镁-精氨酸作为生物墨水的主要成分,通过磁性生物图案技术获得三维肿瘤模型。该生物墨水包含用于磁性操作的磁性纳米粒子(MNPs)、作为牺牲材料的 Mg-alginate 水凝胶和细胞。在使用 HeLa、SaOS-2 和 SH-SY5Y 细胞形成三维肿瘤模型时,对该方法的适用性进行了测试。通过活/死和 MTT 分析对长期培养进行了检验,结果显示细胞存活率很高。随后,在三维肿瘤模型中成功观察到胶原蛋白和 F-肌动蛋白的表达。最后,在三维肿瘤模型上研究了抗癌药物多柔比星(DOX)的效果,并计算了 IC50 值以评估药物反应。结果发现,与二维对照组相比,生物图案化三维肿瘤模型的耐药性明显提高了十倍。总之,镁-精氨酸水凝胶成功地用于形成生物图案化三维肿瘤模型,并有效地显示了该模型的适用性,尤其是作为药物筛选平台的适用性。
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引用次数: 0
Production of Polyvinyl Alcohol/Amoxicillin - Chitosan/Collagen Hybrid Bilayer Membranes for Regeneration of Gingival Tissues. 生产用于牙龈组织再生的聚乙烯醇/阿莫西林-壳聚糖/胶原混合双层膜
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-18 DOI: 10.1002/mabi.202400331
Ayca Aydin, Songul Ulag, Sabereh Nouri, Elif Durasi, Pelin Pelit Arayıcı, Gülgün Bosgelmez Tinaz, Mehmet Mücahit Güncü, Rabia Cakir, Oguzhan Gunduz, Cem Bulent Ustundag

Periodontal diseases, if untreated, can cause gum recession and tooth root exposure, resulting in infection and irreversible damage. Traditional treatments using autologous grafts are painful and often result in postoperative complications. Scaffolds offer a less invasive alternative, promoting cell proliferation and healing without additional surgery, thus enhancing comfort for patients and doctors. This study developed Chitosan (Chit)/Collagen (Col) film surfaces and drug-loaded Polyvinyl Alcohol (PVA)/Amoxicillin (AMX) nanofibers using solvent casting and electrospinning methods, respectively. The surfaces are characterized by scanning electron microscopy (SEM), mechanical testing, Fourier Transform Infrared Spectroscopy (FTIR), and differential scanning calorimetry (DSC). Biocompatibility and antimicrobial properties are assessed using NIH/3T3 fibroblast cells and bacterial cultures. SEM images confirmed the structural integrity of AMX-loaded 13% PVA nanofibers, while FTIR analysis validated the compositional integrity of PVA/AMX nanofibers and Chit/Col film hybrid surfaces. Cell studies showed over 90% viability for Chit/Col film + PVA/AMX nanofiber hybrid bilayer membranes, confirming their biocompatibility. The antimicrobial assessment indicated that the Chit/Col film + PVA/AMX (0.2%) nanofiber hybrid bilayer membrane exhibited superior efficacy against Streptococcus mutans. These findings suggest that this hybrid bilayer membrane can enhance cell growth, promote proliferation, and enable controlled drug release, offering significant promise for regeneration of gingival tissues.

牙周病如果不及时治疗,会导致牙龈萎缩和牙根暴露,造成感染和不可逆的损伤。使用自体移植的传统治疗方法会给患者带来痛苦,并经常导致术后并发症。支架提供了一种创伤较小的替代方法,无需额外手术即可促进细胞增殖和愈合,从而提高了患者和医生的舒适度。本研究采用溶剂浇铸法和电纺丝法分别开发了壳聚糖(Chit)/胶原蛋白(Col)薄膜表面和药物负载的聚乙烯醇(PVA)/阿莫西林(AMX)纳米纤维。通过扫描电子显微镜(SEM)、机械测试、傅立叶变换红外光谱(FTIR)和差示扫描量热法(DSC)对纳米纤维表面进行了表征。使用 NIH/3T3 成纤维细胞和细菌培养物对生物相容性和抗菌特性进行了评估。扫描电子显微镜图像证实了负载 AMX 的 13% PVA 纳米纤维的结构完整性,而傅立叶变换红外光谱分析则验证了 PVA/AMX 纳米纤维和 Chit/Col 薄膜混合表面的成分完整性。细胞研究表明,Chit/Col 膜 + PVA/AMX 纳米纤维混合双层膜的存活率超过 90%,证实了它们的生物相容性。抗菌评估结果表明,Chit/Col 膜 + PVA/AMX (0.2%)纳米纤维混合双层膜对变异链球菌具有卓越的抗菌效果。这些研究结果表明,这种混合双层膜可以增强细胞生长、促进增殖并实现药物的可控释放,为牙龈组织的再生提供了重要的前景。
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引用次数: 0
Masthead: Macromol. Biosci. 11/2024 刊头:Macromol.Biosci.11/2024
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-15 DOI: 10.1002/mabi.202470027
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引用次数: 0
Biochemical Signal-Induced Supramolecular Hydrogelation for Structured Free-Standing Soft Material Formation. 生化信号诱导超分子水凝胶化,形成结构化的独立软材料。
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-15 DOI: 10.1002/mabi.202400419
Dineshkumar Bharathidasan, Akshay Sunil Salvi, Suryasarathi Bose, Chandan Maity

Cells coordinate their activity and regulate biological processes in response to chemical signals. Mimicking natural processes, control over the formation of artificial supramolecular materials is of high interest for their application in biology and medicine. Supramolecular material that can form in response to chemical signals is important for the development of autonomously responsive materials. Herein, a supramolecular hydrogel system is reported enabling in situ generation of hydrogelators in response to a specific chemical signal. Using self-immolative chemistry, spatial control over the formation of supramolecular hydrogel material and structured free-standing hydrogel objects via providing H2O2 locally is demonstrated. In addition, a hybrid system is developed enabling in situ generation of the H2O2 by the action of an enzyme and glucose, providing an extra handle for the development of an intelligent soft material. This generic design should enable the use of various (chemical)stimuli that can be obtained via coupling different stimuli and various chemical and/or biological markers and appears a versatile approach for the design of smart artificial soft materials that can find application in theranostic purposes.

细胞根据化学信号协调其活动并调节生物过程。模仿自然过程,控制人造超分子材料的形成,对其在生物和医学领域的应用具有极大的兴趣。能根据化学信号形成的超分子材料对于开发自主响应材料非常重要。本文报告了一种超分子水凝胶系统,该系统可根据特定化学信号在原位生成水凝胶。利用自惰性化学,通过在局部提供 H2O2,展示了对超分子水凝胶材料和结构化独立水凝胶物体形成的空间控制。此外,还开发了一种混合系统,通过酶和葡萄糖的作用在原位生成 H2O2,为开发智能软材料提供了额外的把手。这种通用设计可以使用各种(化学)刺激,这些刺激可以通过将不同的刺激和各种化学和/或生物标记耦合在一起而获得。
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引用次数: 0
Mechanically Stable and Biocompatible Polymer Brush Coated Dental Materials with Lubricious and Antifouling Properties 具有润滑和防污特性的机械稳定且生物兼容的聚合物刷涂牙科材料
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-15 DOI: 10.1002/mabi.202470026
Rong Mu, Ling Yang, Xinyue Wang, Binrui Yang, Jia Li, Aijun Wang, Guorui Zhang, Chufeng Sun, Yang Wu, Bo Yu, Bin Li

Front Cover: Polymer brushes are grafted to the substrate through surface-initiated atom transfer radical polymerization (SI-ATRP) to form a durable polymeric layer, which enhances surface lubrication, reduces bacterial adhesion, and improves biocompatibility and anti-inflammatory properties. The polymer brush coating shows potential application in dental materials. More details can be found in article 2400194 by Jia Li, Guorui Zhang, Bin Li, and co-workers.

封面:通过表面引发原子转移自由基聚合(SI-ATPR)将聚合物刷接枝到基底上,形成耐久的聚合物层,从而增强表面润滑性,减少细菌粘附,改善生物相容性和消炎特性。这种聚合物刷涂层具有应用于牙科材料的潜力。更多详情,请参阅李佳、张国瑞、李斌及合作者的文章 2400194。
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引用次数: 0
In Situ Forming Injectable Gelatin-Based Antibacterial Bioadhesives for Preventing Postoperative Leakage and Abdominal Adhesions. 用于防止术后渗漏和腹部粘连的原位成型明胶基抗菌生物粘合剂。
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-08 DOI: 10.1002/mabi.202400372
Shibo Hu, Wanglin Duan, Xianzhen Jin, Chaowei Li, Bin Zhu, Yurong Chen, Ye Zhu, Peihai Cao, Zepeng Dong, Luyao Feng, Junhui Yu, Xuejun Sun, Zeshaan Yahaya Haji Mahmood, Yazhong Bu, Baoji Du, Jianbao Zheng

Postoperative anastomotic leakage (AL) and abdominal adhesions are two major complications after intestinal surgery, with an incidence of 2-25% for AL and 93% for adhesion. Until now, there is no method addressing AL and abdominal adhesions simultaneously. In this work, Bi-PEG-succinimidyl succinate (PEG-NHS), amino-gelatin (Agel) is combined with cefoperazone-sulbactam (SCF) to prepare a multifunctional bioadhesive (SCF/SEAgel) for the postoperative leakage and adhesion prevention. SCF/SEAgel possesses a great sealing capability for tissue, with a bursting pressure of 54 kPa. The loaded SCF endows the systems with good antibacterial properties. The in vivo antiadhesion experiments show that SCF/SEAgel possesses better anti-adhesion properties than the commercially used sodium hyaluronate gel. In the cecum leakage model, the SCF/SEAgel effectively seals the leakage with a survival rate of 100%, superior to commercial products (Sainaoning). Meanwhile, it significantly reduces tissue adhesion. Finally, the laparoscopic surgery with dogs shows that the SCF/SEAgel can be injected through minimally invasive surgery, demonstrating its ease of use. Combined with its great biocompatibility, SCF/SEAgel is very promising in intestinal surgery.

术后吻合口漏(AL)和腹腔粘连是肠道手术后的两大并发症,AL 发生率为 2-25%,粘连发生率为 93%。迄今为止,还没有一种方法能同时解决 AL 和腹腔粘连问题。在这项研究中,双 PEG-琥珀酰亚胺丁二酸酯(PEG-NHS)、氨基明胶(Agel)与头孢哌酮-舒巴坦(SCF)结合制备了一种多功能生物粘合剂(SCF/SEAgel),用于术后渗漏和粘连的预防。SCF/SEAgel 对组织具有很强的密封能力,其破裂压力为 54 kPa。负载的 SCF 使该系统具有良好的抗菌性能。体内抗粘连实验表明,SCF/SEA凝胶的抗粘连性能优于市售的透明质酸钠凝胶。在盲肠渗漏模型中,SCF/SEAgel 能有效封堵渗漏,存活率达 100%,优于市售产品(赛宁)。同时,它还能明显减少组织粘连。最后,用狗进行的腹腔镜手术表明,SCF/SEAgel 可以通过微创手术进行注射,证明了它的易用性。SCF/SEAgel 具有良好的生物相容性,因此在肠道手术中大有可为。
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引用次数: 0
Polyamino Acid Based Zwitterionic Coating can Inhibit Coagulation and Inflammation Through Anti-Fouling and Restoring Microenvironment. 聚氨基酸型聚合离子涂层可通过防污和恢复微环境来抑制凝血和炎症。
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-08 DOI: 10.1002/mabi.202400336
Zehong Xiang, Honghong Chen, Feng Wu, Haobo Pan

Protein adhesion and thrombosis formation caused by limited surface properties pose great challenges to biomedical implants. Although various hydrophilic coating or drug release coatings are reported, the single coating cannot cope with cases under the condition of complex physiological environment, which causes the coating effect is limited. In this study, a polyamino acid-derived zwitterionic coating is constructed to eliminate reactive oxygen species (ROS) in the microenvironment. It is demonstrated that the coating has excellent hydrophilicity, stability, and lubricity, and can obviously prevent protein adhesion. At the same time, the coating can eliminate hydrogen peroxide and maintain the stability of the microenvironment. The in vivo and in vitro experiments show that the coating has good biocompatibility, and inhibits thrombus. Amino acid zwitterion coating prevents protein deposition, alleviates the inflammatory process, inhibit of thrombosis, reduces the risk of implantable medical devices, and prolongs their service time. Hence, the work paves a new way to develop amino acid based zwitterionic polymer coating that can reduce the implant complications.

由于表面性能有限而导致的蛋白质粘附和血栓形成给生物医学植入物带来了巨大挑战。虽然目前已有多种亲水涂层或药物释放涂层的报道,但单一涂层无法应对复杂生理环境条件下的病例,导致涂层效果有限。本研究构建了一种源于聚氨基酸的齐聚物涂层,以消除微环境中的活性氧(ROS)。研究表明,该涂层具有良好的亲水性、稳定性和润滑性,能明显防止蛋白质粘附。同时,涂层还能消除过氧化氢,保持微环境的稳定性。体内和体外实验表明,涂层具有良好的生物相容性,并能抑制血栓形成。氨基酸齐聚物涂层可防止蛋白质沉积,缓解炎症过程,抑制血栓形成,降低植入式医疗器械的风险,延长其使用寿命。因此,这项研究为开发能减少植入并发症的氨基酸型齐聚物涂层铺平了新的道路。
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引用次数: 0
Surface Coating of ZIF-8 Nanoparticles with Polyacrylic Acid: A Facile Approach to Enhance Chemical Stability for Biomedical Applications. 用聚丙烯酸对 ZIF-8 纳米粒子进行表面涂层:增强生物医学应用中化学稳定性的简便方法。
IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-03 DOI: 10.1002/mabi.202400382
Setsuko Yamane, Abdul Hadi Bin Yusri, Po-Yu Chen, André J van der Vlies, Amira Ben Mabrouk, Isabelle Fetzer, Urara Hasegawa

Nanoparticles of zeolitic imidazole framework-8 (ZIF-8 NPs), which are the subclass of metal-organic frameworks consisting of Zn ion and 2-methylimidazole, have been identified as promising drug carriers since their large microporous structure is suited for encapsulating hydrophobic drug molecules. However, one of the limitations of ZIF-8 NPs is their low stability in physiological solutions, especially in the presence of water and phosphate anions. These molecules can interact with the coordinatively unsaturated Zn sites at the external surface to induce the degradation of ZIF-8 NPs. In this study, herein a facile approach is reported to enhance the chemical stability of ZIF-8 NPs by surface coating with polyacrylic acid (PAA). The PAA-coated ZIF-8 (PAA-ZIF-8) NPs are prepared by mixing ZIF-8 NPs and PAA in water. PAA coating inhibits the degradation of ZIF-8 NPs in water as well as phosphate-buffered saline over 6 days, which seems to be due to the coordination of carboxyl groups of PAA to the reactive Zn sites. Furthermore, the PAA-ZIF-8 NPs loaded with the anticancer drug doxorubicin (Dox) show cytotoxicity in human colon cancer cells. These results clearly show the feasibility of the PAA coating approach to improve the chemical stability of ZIF-8 NPs without impairing their drug delivery capability.

沸石咪唑框架-8(ZIF-8 NPs)纳米粒子是由锌离子和 2-甲基咪唑组成的金属有机框架的亚类,由于其大微孔结构适合封装疏水性药物分子,因此被认为是很有前途的药物载体。然而,ZIF-8 NPs 的局限性之一是其在生理溶液中的稳定性较低,尤其是在有水和磷酸盐阴离子存在的情况下。这些分子会与外表面配位不饱和的锌位点相互作用,导致 ZIF-8 NPs 降解。本研究采用一种简便的方法,通过表面涂覆聚丙烯酸(PAA)来增强 ZIF-8 NPs 的化学稳定性。PAA 涂层 ZIF-8 (PAA-ZIF-8) NPs 由 ZIF-8 NPs 和 PAA 在水中混合制备而成。PAA 涂层可抑制 ZIF-8 NPs 在水中和磷酸盐缓冲盐水中 6 天的降解,这似乎是由于 PAA 的羧基与反应性 Zn 位点配位所致。此外,负载抗癌药物多柔比星(Dox)的 PAA-ZIF-8 NPs 对人类结肠癌细胞具有细胞毒性。这些结果清楚地表明了 PAA 涂层方法在不影响 ZIF-8 NPs 药物输送能力的前提下提高其化学稳定性的可行性。
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引用次数: 0
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Macromolecular bioscience
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