Role of metabolites in mediating the effect of triacylglycerol on aplastic anemia.

IF 2 4区医学 Q3 HEMATOLOGY Hematology Pub Date : 2024-12-01 Epub Date: 2024-07-17 DOI:10.1080/16078454.2024.2379178

Jingkui Zhu, Wen Li

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Abstract

Background: Observational studies have found a link between lipid metabolism disorders and aplastic anemia (AA). However, due to confounding variables and reverse causation, it is difficult to conclude such a causal link. The precise mechanism and potential implications of lipid metabolism disorder in AA remain unclear, necessitating further studies in this area.

Method: This study aimed to examine the causal relationship between 38 different subtypes of triacylglycerols and AA using two-sample Mendelian randomization (MR). Additionally, two-step MR analyses were conducted to investigate the mediating effects of vitamin A to oleoyl-linoleoyl-glycerol (18:1-18:2) ratio.

Results: MR analysis showed that triacylglycerol (53:3) levels were positively associated with the risk of AA [inverse variance weighting (IVW): odds ratio (OR) = 1.131,95% confidence interval (CI):1.029-1.243, P = 0.011; Bayesian weighted MR (BWMR): OR = 1.137,95% CI:1.031-1.254, P = 0.010]. Triacylglycerol (53:3) level showed no inverse causality with AA (IVW:P = 0.834; BWMR:P = 0.349). Mediation analyses showed that increasing the vitamin A to oleoyl-linoleoyl-glycerol (18:1-18:2) ratio can decrease the risk of AA.

Conclusion: This study revealed the association between vitamin A to oleoyl-linoleoyl-glycerol (18:1-18:2) ratio, triacylglycerol (53:3) levels and AA, and indicated that lowering triacylglycerol (53:3) levels can reduce the risk of AA.

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代谢物在调节三酰甘油对再生障碍性贫血的影响中的作用

背景：观察性研究发现，脂质代谢紊乱与再生障碍性贫血（AA）之间存在联系。然而，由于混杂变量和反向因果关系，很难得出这种因果关系的结论。脂质代谢紊乱在再生障碍性贫血中的确切机制和潜在影响仍不清楚，因此有必要在这一领域开展进一步研究：本研究旨在使用双样本孟德尔随机法（MR）研究 38 种不同亚型的三酰甘油与 AA 之间的因果关系。此外，还进行了两步 MR 分析，以研究维生素 A 与油酰基-亚油酰基甘油（18:1-18:2）比率的中介效应：或 = 1.137，95% 置信区间：1.031-1.254，P = 0.010]。三酰甘油（53:3）水平与 AA 没有反向因果关系（IVW:P = 0.834；BWMR:P = 0.349）。中介分析表明，提高维生素 A 与油酰基-亚油酰基甘油（18:1-18:2）的比率可降低 AA 风险：本研究揭示了维生素 A 与油酰基-亚油酰基-甘油（18:1-18:2）比率、三酰甘油（53:3）水平与 AA 之间的关系，并指出降低三酰甘油（53:3）水平可降低 AA 风险。

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来源期刊

Hematology 医学-血液学

CiteScore

2.60

自引率

5.30%

发文量

140

审稿时长

3 months

期刊介绍： Hematology is an international journal publishing original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. Of the fixed sections, annotations are accepted on any general or scientific field: technical annotations covering current laboratory practice in general hematology, blood transfusion and clinical trials, and current clinical practice reviews the consensus driven areas of care and management.