Gas-sensing riboceptors.

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY RNA Biology Pub Date : 2024-01-01 Epub Date: 2024-07-17 DOI:10.1080/15476286.2024.2379607
Savani Anbalagan
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Abstract

Understanding how cells sense gases or gaseous solutes is a fundamental question in biology and is pivotal for the evolution of molecular and organismal life. In numerous organisms, gases can diffuse into cells, be transported, generated, and sensed. Controlling gases in the cellular environment is essential to prevent cellular and molecular damage due to interactions with gas-dependent free radicals. Consequently, the mechanisms governing acute gas sensing are evolutionarily conserved and have been experimentally elucidated in various organisms. However, the scientific literature on direct gas sensing is largely based on hemoprotein-based gasoreceptors (or sensors). As RNA-based G-quadruplex (G4) structures can also bind to heme, I propose that some ribozymes can act as gas-sensing riboceptors (ribonucleic acid receptors). Additionally, I present a few other ideas for non-heme metal ion- or metal cluster-based gas-sensing riboceptors. Studying riboceptors can help understand the evolutionary origins of cellular and gasocrine signaling.

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气体感应核素受体
了解细胞如何感知气体或气态溶质是生物学的一个基本问题,对于分子和生物体生命的进化至关重要。在许多生物体中,气体可以扩散到细胞中,并被运输、生成和感知。控制细胞环境中的气体对于防止细胞和分子因与依赖气体的自由基相互作用而受损至关重要。因此,控制急性气体感应的机制在进化过程中是保守的,并已在各种生物体内得到实验阐明。然而,有关直接气体感应的科学文献主要基于基于血蛋白的气体感受器(或传感器)。由于基于核糖核酸的 G-四重(G4)结构也能与血红素结合,我建议一些核糖酶可以充当气体感应核糖受体(核糖核酸受体)。此外,我还提出了一些关于基于非血红素金属离子或金属簇的气体感应核糖受体的其他想法。研究核糖受体有助于了解细胞和气分泌信号的进化起源。
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来源期刊
RNA Biology
RNA Biology 生物-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
82
审稿时长
1 months
期刊介绍: RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy
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