Exploring the therapeutic potential of dioscin and diosgenin in neurological disorders

Abstract

This comprehensive review delves into the potential therapeutic efficacy of dioscin and diosgenin, phytocompounds extracted from the Dioscoreaceae family, in alleviating neurological disorders. The article meticulously elucidates the putative neuroprotective mechanisms of dioscin and diosgenin in various neurological disorders, emphasizing their ability to mitigate cognitive impairments, diminish neuropathological hallmarks, and suppress neuroinflammatory responses. A detailed discussion of the pharmacokinetic profiles of dioscin and diosgenin, encompassing their distribution and bioavailability following administration, is also presented. Additionally, the paper outlines the challenges and prospective directions in translating preclinical findings about dioscin and diosgenin into clinically relevant applications, underscoring the need for more rigorous clinical trials and standardized formulations. The summary accurately captures the key findings and highlights these natural compounds' potential in treating various neurological conditions.