Treating young adult cannabis use disorder with text message-delivered peer network counseling

IF 2 3区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Contemporary clinical trials Pub Date : 2024-07-15 DOI:10.1016/j.cct.2024.107635
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Abstract

Background

Approximately 16.5% of U.S. young adults have a cannabis use disorder (CUD) and are at risk for negative outcomes. Treatment can reduce cannabis use, but young adults are less likely to seek help than older adults. Peer Network Counseling-txt (PNC-txt) is a brief, text-delivered, Motivational Interviewing-informed substance use intervention focusing on peer relations and activity spaces as mechanisms for behavioral change. PNC-txt has shown evidence of reducing tobacco and cannabis use with adolescents and young adults, but it has not been tested in the context of legal cannabis use. The current randomized controlled trial sought to expand the evidence regarding the context of PNC-txt effects, comparing one state in which cannabis is legal (Colorado) and one state in which it is not (Tennessee). We hypothesized that participants randomized to PNC-txt would show significant reductions in cannabis use compared to controls, with larger reductions for females and those in Colorado, and that peer relations and activity space would mediate effects.

Methods

One thousand, seventy eight 18–25 year olds (CO: 551; TN: 527) who met screening criteria for CUD and biologically-verified cannabis use were randomly assigned to PNC-txt or waitlist control condition. Every other day for 4 weeks, participants assigned to PNC-txt received pre-programmed text conversations, tailored via data from the baseline assessment. Self-report and biological indicators of cannabis use were measured at 1-, 3-, and 6-months.

Discussion

Data analysis is underway. Results will provide evidence regarding whether, and how, PNC-txt reduces cannabis use in young adults with CUD.

Trial registration

This trial was prospectively registered on September 28, 2020 with ClinicalTrials.gov (NCT04567394).

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通过短信传递同伴网络咨询治疗年轻成人大麻使用障碍。
背景:美国约有 16.5% 的青壮年患有大麻使用障碍 (CUD),有可能导致不良后果。治疗可以减少大麻使用,但与老年人相比,年轻人寻求帮助的可能性较低。同伴网络咨询-txt(PNC-txt)是一种简短的、通过文本传递的、以动机访谈为基础的药物使用干预措施,其重点是将同伴关系和活动空间作为行为改变的机制。有证据表明,PNC-txt 可减少青少年和年轻成年人使用烟草和大麻,但尚未在合法使用大麻的情况下进行过测试。目前的随机对照试验试图通过比较一个大麻合法的州(科罗拉多州)和一个大麻不合法的州(田纳西州)来扩大 PNC-txt 效果的证据范围。我们的假设是,与对照组相比,随机使用 PNC-txt 的参与者使用大麻的情况将显著减少,女性和科罗拉多州的参与者减少的幅度更大,而且同伴关系和活动空间将对效果起到中介作用:将符合 CUD 筛选标准并经生物学证实使用大麻的 178 名 18-25 岁青少年(科罗拉多州:551 人;田纳西州:527 人)随机分配到 PNC-txt 或候补对照组。在为期 4 周的时间里,每隔一天,被分配到 PNC-txt 的参与者都会收到根据基线评估数据定制的预设文本对话。在 1 个月、3 个月和 6 个月时对大麻使用的自我报告和生物指标进行测量:讨论:数据分析正在进行中。结果将为 PNC-txt 是否以及如何减少患有 CUD 的年轻人使用大麻提供证据:该试验于 2020 年 9 月 28 日在 ClinicalTrials.gov 进行了前瞻性注册(NCT04567394)。
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来源期刊
CiteScore
3.70
自引率
4.50%
发文量
281
审稿时长
44 days
期刊介绍: Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.
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