The impact of mitochondrial impairments on sperm function and male fertility: a systematic review.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Reproductive Biology and Endocrinology Pub Date : 2024-07-17 DOI:10.1186/s12958-024-01252-4

Minoo Vahedi Raad, Amir Masoud Firouzabadi, Maryam Tofighi Niaki, Ralf Henkel, Farzaneh Fesahat

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Abstract

Background: Besides adenine triphosphate (ATP) production for sustaining motility, the mitochondria of sperm also host other critical cellular functions during germ cell development and fertilization including calcium homeostasis, generation of reactive oxygen species (ROS), apoptosis, and in some cases steroid hormone biosynthesis. Normal mitochondrial membrane potential with optimal mitochondrial performance is essential for sperm motility, capacitation, acrosome reaction, and DNA integrity.

Results: Defects in the sperm mitochondrial function can severely harm the fertility potential of males. The role of sperm mitochondria in fertilization and its final fate after fertilization is still controversial. Here, we review the current knowledge on human sperm mitochondria characteristics and their physiological and pathological conditions, paying special attention to improvements in assistant reproductive technology and available treatments to ameliorate male infertility.

Conclusion: Although mitochondrial variants associated with male infertility have potential clinical use, research is limited. Further understanding is needed to determine how these characteristics lead to adverse pregnancy outcomes and affect male fertility potential.

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线粒体损伤对精子功能和男性生育能力的影响：系统综述。

背景：精子线粒体除了产生维持精子运动的三磷酸腺嘌呤（ATP）外，在生殖细胞发育和受精过程中还承担着其他重要的细胞功能，包括钙平衡、活性氧（ROS）生成、细胞凋亡以及某些情况下的类固醇激素生物合成。正常的线粒体膜电位和最佳的线粒体性能对精子的运动、获能、顶体反应和 DNA 完整性至关重要：结果：精子线粒体功能缺陷会严重损害男性的生育能力。精子线粒体在受精过程中的作用以及受精后的最终归宿仍存在争议。在此，我们回顾了目前有关人类精子线粒体特征及其生理和病理状况的知识，并特别关注了辅助生殖技术的改进和改善男性不育症的现有治疗方法：结论：尽管与男性不育有关的线粒体变异具有潜在的临床应用价值，但相关研究还很有限。结论：虽然与男性不育有关的线粒体变异具有潜在的临床应用价值，但研究还很有限，需要进一步了解这些特征是如何导致不良妊娠结局和影响男性生育潜力的。

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来源期刊

Reproductive Biology and Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.30%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.