The liminal space of first-episode psychosis and its treatment: A qualitative study exploring the experience of young people participating in an antipsychotic dose reduction randomized controlled trial.
Jesse Gates, Carli Ellinghaus, Lee Valentine, Ilias Kamitsis, Alexandra Stainton, Susy Harrigan, Andrew Thompson, Mario Alvarez-Jimenez, Stephen Wood, Andrea Polari, John F Gleeson, Cali Bartholomeusz, Kelly Allott, Eóin Killackey, Sarah Bendall
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Abstract
Objective: The current guidelines recommend continuation of antipsychotic medication for a minimum of at least 1 year following a first episode of psychosis (FEP). There have been several trials investigating whether early dose reduction or cessation leads to improved functional outcomes. The aim of this study was to explore the experience of consenting to and participating in a randomized controlled trial (RCT) of antipsychotic medication cessation.
Method: Five participants in the Reduce trial-an RCT evaluating early antipsychotic medication dose reduction/cessation following FEP-aged 22-24 years completed a semistructured qualitative interview following the RCT. Interpretive phenomenological analysis was undertaken to understand the key themes.
Results: A superordinate theme was derived from interviews: the Liminal Space of FEP and treatment. Themes within the Liminal Space included: rejection versus identification with psychosis, medication as symbolic of illness versus wellness, embodiment of wellness and illness with medication, medication as symbolic of independence versus dependence, discovery of independence when autonomously choosing medication, the Reduce trial offered safety to navigate the liminal space, and self-exploration versus altruism.
Conclusions and implications for practice: The experience and treatment of FEP involves young people feeling torn between multiple, competing perspectives, demands, and priorities. Participation in an RCT exploring dose reduction provided additional supports contributing to the perception of greater safety to navigate their own experiences of treatment that was appropriate for them. When treatment is experienced as collaborative, involves shared decision making and support, other than medication, young people feel more equipped to navigate the liminal space. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
期刊介绍：
The Psychiatric Rehabilitation Journal is sponsored by the Center for Psychiatric Rehabilitation, at Boston University"s Sargent College of Health and Rehabilitation Sciences and by the US Psychiatric Rehabilitation Association (USPRA) . The mission of the Psychiatric Rehabilitation Journal is to promote the development of new knowledge related to psychiatric rehabilitation and recovery of persons with serious mental illnesses.
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