Management of methicillin-resistant Staphylococcus aureus mediated ventilator-associated pneumonia.

Current trends in microbiology Pub Date : 2018-01-01
Manisha Dahal, William R Schwan
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Abstract

Prevention strategies and clinical management of methicillin- resistant Staphylococcus aureus (MRSA) infections in ventilated patients who develop ventilator-associated pneumonia (VAP) are important. Since MRSA are the most frequently isolated bacteria in patients with VAP, and a significant cause of morbidity and mortality in intubated patients, rapid diagnosis and early treatment could reduce mortality. This review will examine preventive steps (i.e. screening ventilated patients for MRSA, decolonization, and hand washing), assessing clinical presentations before the results of culture are obtained to direct empiric treatment, and the appropriate antibiotic therapy upon culture confirmation of MRSA that could help in the management of VAP.

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耐甲氧西林金黄色葡萄球菌介导的呼吸机相关肺炎的管理。
在发生呼吸机相关肺炎(VAP)的呼吸机患者中,耐甲氧西林金黄色葡萄球菌(MRSA)感染的预防策略和临床管理非常重要。由于 MRSA 是 VAP 患者中最常分离出的细菌,也是导致插管患者发病和死亡的重要原因,因此快速诊断和早期治疗可降低死亡率。本综述将探讨预防措施(即对通气患者进行 MRSA 筛查、去菌和洗手)、在获得培养结果前评估临床表现以指导经验性治疗,以及在培养确认 MRSA 后进行适当的抗生素治疗,以帮助管理 VAP。
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Protein N-terminal acylation: An emerging field in bacterial cell physiology. T cell responses to adenoviral vectors expressing the SARS-CoV-2 nucleoprotein. Management of methicillin-resistant Staphylococcus aureus mediated ventilator-associated pneumonia. New insights on the development of Streptomyces and their relationships with secondary metabolite production.
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