Prevalence of depression or depressive state in patients with restless legs syndrome: A systematic review and meta-analysis

IF 11.2 1区 医学 Q1 CLINICAL NEUROLOGY Sleep Medicine Reviews Pub Date : 2024-07-11 DOI:10.1016/j.smrv.2024.101975
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Abstract

Restless legs syndrome (RLS) is a common sleep-related disorder characterized by limb discomfort and the urge to move them when at rest, especially in the evening or at night. Although depression is often linked to various conditions, no systematic review has assessed depression prevalence in patients with RLS after the latest diagnostic criteria revision. This systematic review and meta-analysis aimed to investigate the depression and depressive state prevalence among patients with RLS. We systematically searched databases up to November 2022 and performed meta-analyses of the depression prevalence using a random-effects model and a meta-regression analysis to explore the relationship between the prevalence and severity of depression and factors such as age and RLS severity. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we analyzed 24 studies with 2039 patients. The pooled depression or depressive state prevalence, mostly defined by questionnaire scores, was 30.39 %. Nine studies reported the proportion of patients taking antidepressants (pooled rate: 3.41 %). No specific factors related to the prevalence or severity of depression were identified in patients with RLS. These findings highlight the significant prevalence of depression and underscore the need for future research with standardized diagnostic interviews and consistent methodologies across multi-site studies.

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不宁腿综合征患者中抑郁或抑郁状态的患病率:系统回顾与荟萃分析
不宁腿综合征(RLS)是一种常见的睡眠相关疾病,其特征是肢体不适,休息时有移动肢体的冲动,尤其是在傍晚或夜间。虽然抑郁症通常与各种疾病有关,但在最新诊断标准修订后,还没有系统性综述评估过 RLS 患者的抑郁症患病率。本系统综述和荟萃分析旨在研究 RLS 患者中抑郁和抑郁状态的发生率。我们系统检索了截至 2022 年 11 月的数据库,并使用随机效应模型和元回归分析对抑郁患病率进行了元分析,以探讨抑郁患病率和严重程度与年龄和 RLS 严重程度等因素之间的关系。根据《系统综述和元分析首选报告项目》指南,我们对 24 项研究的 2039 名患者进行了分析。汇总的抑郁或抑郁状态患病率为 30.39%,主要由问卷评分界定。九项研究报告了服用抗抑郁药物的患者比例(汇总比例:3.41%)。在 RLS 患者中,没有发现与抑郁症患病率或严重程度相关的特定因素。这些研究结果突显了抑郁症的显著患病率,并强调今后的研究需要采用标准化的诊断访谈和一致的方法进行多地点研究。
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来源期刊
Sleep Medicine Reviews
Sleep Medicine Reviews 医学-临床神经学
CiteScore
20.10
自引率
3.80%
发文量
107
期刊介绍: Sleep Medicine Reviews offers global coverage of sleep disorders, exploring their origins, diagnosis, treatment, and implications for related conditions at both individual and public health levels. Articles comprehensively review clinical information from peer-reviewed journals across various disciplines in sleep medicine, encompassing pulmonology, psychiatry, psychology, physiology, otolaryngology, pediatrics, geriatrics, cardiology, dentistry, nursing, neurology, and general medicine. The journal features narrative reviews, systematic reviews, and editorials addressing areas of controversy, debate, and future research within the field.
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