Blood levels of metallic chemical element exposure patterns and associated factors in a population living in an Industrial District in Brazil

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Trace Elements in Medicine and Biology Pub Date : 2024-07-14 DOI:10.1016/j.jtemb.2024.127498

Maria Cristina Ferreira Lemos , Rosalina Jorge Koifman , Fernando Barbosa Jr , Valéria Saraceni , Evanelza Quadros , Rafael do Nascimento Pinheiro , Vanessa Cristina de Oliveira Souza , Rafaela Soares Senra da Costa , Ilce Ferreira da Silva

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Abstract

AIM:to estimate the level of metallic chemical elements in the population living in the Steel company vicinity in Santa Cruz, Rio de Janeiro, Brazil; and estimate the association between exposure to the Steel company and the blood metals concentrations patterns.METHOD:A cross-sectional study was carried out on 463 individuals aged 18+ years old residing 1+ years in the Steel company vicinity. Mg, Be, Co, Ba, Ni, Cd, Al, and Pb were assessed in blood by DRC-ICP-MS. Metallic chemical element concentration patterns were obtained by exploratory factor analysis in the studied population. Exposure was set as the distance (Km) from each participant's residence to the Steel company in Santa Cruz, georeferenced by GPS. The outcome was set as the positive factor loadings in the factor analysis, including Mg and Be (Factor-1), Co, Ba, and Ni (Factor-2), Cd, Al, and Pb (Factor-4). Crude and adjusted OR, and their respective 95 %CI, were estimated to explore associations between independent variables and the exposures to metallic elements positively associated with the factors using polychotomous logistic regression.RESULTS:A reduction of 19 % was found between each km distance from the residence and the Steel company and P₅₀ concentration of Cd, Al, and Pb (OR_P50=0.81; 95 %CI:0.67–0.97), after adjusting by age, sex, and smoking. No statistically significant associations were observed for the distance from residences and the Steel company, after adjusting for age, gender, having a domestic vegetable garden and chewing gum for Mg and Be concentrations (Factor-1) (OR_P50=0.84; 95 %CI:0.70–1.01; OR_P75=1.10; 95 %CI:0.91–1.34); nor for Co, Ba and Ni (Factor-2) blood concentrations(OR_P50=1.10; 95 %CI:0.91–1.33; OR_P75=1.03; 95 %CI:0.84–1.26), in the adjusted analysis.CONCLUSIONS: For each Km distance from residences to the Steel company, a 19 % reduction in the risk of Cd, Al, and Pb blood concentration was observed in the population living in Santa Cruz, Rio de Janeiro, Brazil.

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巴西工业区居民血液中金属化学元素暴露水平模式及相关因素

目的：估算巴西里约热内卢圣克鲁斯钢铁公司附近居民体内的金属化学元素含量，并估算接触钢铁公司与血液中金属浓度模式之间的关联。方法：对居住在钢铁公司附近 1 年以上、年龄在 18 岁以上的 463 人进行了横断面研究。通过 DRC-ICP-MS 对血液中的镁、铍、钴、钡、镍、镉、铝和铅进行了评估。通过探索性因子分析，得出了研究人群中金属化学元素的浓度模式。根据全球定位系统（GPS）的地理坐标，将辐照度设定为从每位参与者的住所到圣克鲁斯钢铁公司的距离（公里）。结果设定为因子分析中的正因子载荷，包括镁和铍（因子-1），钴、钡和镍（因子-2），镉、铝和铅（因子-4）。结果：在对年龄、性别和吸烟情况进行调整后，发现从居住地到钢铁公司的每千米距离与镉、铝和铅的 P50 浓度之间的关系降低了 19%（ORP50=0.81；95 %CI：0.67-0.97）。在对年龄、性别、拥有家庭菜园和咀嚼口香糖等因素进行调整后，镁和铍的浓度（因子-1）与居住地和钢铁公司的距离没有明显的统计学关联（ORP50=0.84；95 %CI:0.70-1.01；ORP75=1.10；95 %CI:0.91-1.34）；在调整分析中，钴、钡和镍（因子-2）的血液浓度（ORP50=1.10；95 %CI:0.91-1.33；ORP75=1.03；95 %CI:0.84-1.26）也是如此：在巴西里约热内卢圣克鲁斯的居民中，从住宅到钢铁公司的距离每增加一公里，镉、铝和铅的血液浓度风险就会降低19%。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.