Reactive oxygen species generation for catalysis and biotherapeutic applications based on crystalline porous materials

Abstract

Reactive oxygen species (ROS), which are traditionally recognized for their ability to damage biological molecules, have recently emerged as potential catalysts and agents in biotherapeutic applications due to their distinctive chemical properties and biological effects. Crystalline porous materials have garnered considerable attention in ROS generation and applications, thanks to their well-defined structures, large surface areas, and highly customizable properties, offering promising avenues for precise control of ROS production and subsequent release. In this review, we begin by detailing the advantages of crystalline porous materials in ROS manipulation. Subsequently, we introduce the mechanisms of ROS generation, particularly within crystalline porous materials. We then showcase the utilization of ROS in catalysis by crystalline porous materials, emphasizing the roles of different ROS types in facilitating efficient and selective reactions. Additionally, the application of ROS biotherapeutics, particularly in targeted therapy, based on various strategies for ROS generation, has been summarized. Finally, the remaining challenges and prospects for further advancing crystalline porous materials in the realm of ROS-related research and development are discussed.