Coordination Chemistry Reviews最新文献

Bacterial infections and foodborne illnesses, resulting from bacterial pathogens, have posed global public health issues. Precisely recognizing bacterial pathogens, along with signal readout and mathematical analysis, is the first and crucial step in ensuring their sensitive and specific detection, yielding prompt clinical treatment, and reducing instances of foodborne illness. Utilizing the abundant glycan moieties present on the outer surface of bacteria, boronic acid-based biosensing platforms have emerged as appealing solutions for facilitating the sensitive, accurate, rapid, and high-throughput screening of pathogenic bacteria. This review comprehensively introduces the updated applications of boronate affinity approaches in detecting ultra-low levels of bacterial pathogens and accurately distinguishing mixed pathogens in complex samples, highlighting the benefits of boronic acid ligands in the pathogen detection. Starting with an overview of the surface morphologies of bacterial pathogens and their role in facilitating robust boronate affinity interactions and the preparation of boronate affinity platforms, the applications of boronic acid-functionalized biosensors for bacterial detection are further summarized. Furthermore, the simultaneous detection of multiple bacterial pathogens and the effective discrimination of bacterial mixtures with the assistance of quantitative multivariate algorithms are illustrated. Additionally, perspectives that shed light on improving the sensitivity, specificity, robustness, pH adaptability, and applicability of boronic acid ligands, are highlighted. This review intends to offer valuable and state-of-the-art information regarding the preparation and applications of boronate affinity platforms for pathogen detection, contributing to clinical bacterial treatment and food safety.

Recently, covalent organic frameworks (COFs), as emerging structures produced by assembling organic building blocks via covalent bonds, have drawn great attention for water treatment due to their high surface area and pores, numerous functional groups, and excellent chemical stability. Applying appropriate functional groups and building units and making COF-based composites represented effective strategies to enhance removal efficiency. In the photocatalytic, membrane separation, and adsorption processes, these strategies can result in the production of more charge carriers and degradative species, controlling water flow and rejection, and selective adsorption of organic pollutants. In this comprehensive review, the synthesis and modification methods of COFs and the recent advancement of their application in the removal of organic pollutants from water by adsorption, photocatalytic, and membrane separation processes were highlighted. Finally, the current challenges and future perspectives in the application of COFs in these processes are discussed.

Reactive oxygen species (ROS), which are traditionally recognized for their ability to damage biological molecules, have recently emerged as potential catalysts and agents in biotherapeutic applications due to their distinctive chemical properties and biological effects. Crystalline porous materials have garnered considerable attention in ROS generation and applications, thanks to their well-defined structures, large surface areas, and highly customizable properties, offering promising avenues for precise control of ROS production and subsequent release. In this review, we begin by detailing the advantages of crystalline porous materials in ROS manipulation. Subsequently, we introduce the mechanisms of ROS generation, particularly within crystalline porous materials. We then showcase the utilization of ROS in catalysis by crystalline porous materials, emphasizing the roles of different ROS types in facilitating efficient and selective reactions. Additionally, the application of ROS biotherapeutics, particularly in targeted therapy, based on various strategies for ROS generation, has been summarized. Finally, the remaining challenges and prospects for further advancing crystalline porous materials in the realm of ROS-related research and development are discussed.

Carbon-rich macrocycles and nanobelts have attracted considerable attention for decades because their aesthetically molecular structures, excellent physical properties, and potential applications as precursor to construct carbon-based materials or macrocyclic hosts in supramolecular chemistry. Introduction of heteroatom into carbon-rich macrocycles is a popular strategy to regulate their electronic structure, which can endow its new function and application. In recent years, heteroatom-contained carbon-rich macrocycles and nanobelts with increasingly diversified structures and properties have become a new hot spot in the field of supramolecular and material science. This review focuses on the development of carbon-rich macrocycles and belt in recent years, including their design and synthesis, photophysical characteristics, coordination chemistry, etc.

Technological innovation has enabled the development of new materials, with two-dimensional materials garnering much interest in recent years. Transition metal nitrides, oxycarbides, carbonitrides, and carbides, collectively termed MXenes, display favorable chemical and physical properties. A striking feature of MXenes is their diverse elemental makeups and ability to have multiple surface functional groups, providing a versatile platform to create novel composites. Indeed, many MXene-polymer composites have already been made using different polymers, allowing fine-tuning for intended uses. These materials have been used in a wide spectrum of environmental research, being applied in processes such as photocatalysis, electrochemical water splitting, contaminant removal, desalination, CO₂ reduction, hydrogen evolution, and sensing. This review comprehensively surveys recent progress in MXene-polymer composites, including fabrication approaches, and modification strategies. Moreover, it systematically categorizes the applications of MXene-polymer composites for different water treatment applications such as desalination, removing heavy metals, dyes, pharmaceutical residuals, hazardous materials, natural organic matters, and oil–water separation among others. Finally, it addresses challenges, limitations, and future directions for these composites, while introducing potential ways to enhance MXenes to further expand MXene-polymer composite utilities going forward.

Coordination chemistry studies metal complexes and their interactions with ligands, and it has emerged as a powerful tool in developing molecular probes for CRISPR-Cas-based point-of-care testing (POCT) systems. For instance, metal complexes like ruthenium and platinum have been used to selectively bind and detect specific nucleic acid sequences. These complexes can act as molecular beacons, fluorescent dyes, colorimetric and luminescence probes, and electrochemical tags, which allow for the precise identification and quantification of nucleic acid and non-nucleic acid targets with exceptional sensitivity and specificity. This article demonstrates the crucial role played by coordination chemistry in CRISPR-Cas-based POCTs. It focuses specifically on developing molecular probes and their applications in molecular diagnostics. The article explores the principles behind designing metal complexes for target recognition and detection strategies and integrating these probes into CRISPR-Cas systems for swift and accurate detection. The review also examines the challenges faced in this field and the future directions, highlighting the potential impact of coordination chemistry on advancing CRISPR-Cas-based POCT technologies.

Myelin is an important component of the central nervous system, formed by glial cells surrounding neurons. Its damage is closely associated with diseases, such as multiple sclerosis and white matter malnutrition, making the myelin a potentialized target. Therefore, conducting myelin imaging highly benefits for the early diagnosis and treatment of related diseases. Fluorescence imaging has advantages such as high sensitivity, high specificity, and high signal-to-noise ratio, which can effectively image the myelin and indicate changes in its content. This review summarizes fluorescence imaging techniques used for myelin imaging in recent decades, focusing on the principles and applications of these techniques, and purposing prospects for future development. We hope that the development of fluorescence imaging techniques will provide researchers with new insights into the structure and distribution of myelin, as well as powerful research tools for studying key processes such as nervous system development, degeneration, and regeneration.

In the past decades, phototherapy has been explored in the field of cancer treatment owing to its advantages of high selectivity, excellent efficiency, and negligible drug resistance. Phototherapy relies on agents that generate hyperthermia or reactive oxygen species to allow specific targeting and tumor ablation. However, mono-phototherapy only shows modest efficiency, which cannot fight recalcitrant tumors completely and is usually accompanied by recurrence or metastasis, especially in clinics. Therefore, combining other therapeutic strategies (e.g., chemotherapy, radiotherapy, immunotherapy, gene therapy, anti-angiogenesis therapy, sonodynamic therapy, gas therapy, chemodynamic therapy, and starvation therapy) or novel modifications with phototherapy greatly increases clinical therapeutic potential and opens new horizons in oncology treatment. This review outlines the latest advances in phototherapeutic-based nanoparticles to fight cancer and their preclinical and clinical developments. First, cancer mono-phototherapy is summarized. Subsequently, phototherapy strategies combined with other therapeutic methods are reviewed. Finally, major challenges and perspectives of cancer phototherapy are discussed. This review provides a detailed introduction to cancer phototherapy and the combination strategies that promote significant remediation for future clinical translation.

The efficient utilization of triplet excitons serves as a key driver for the advancement of luminescence materials. Therefore, coordination compounds based on phosphorescence (PL) and thermally activated delayed fluorescence (TADF) mechanisms play a crucial role in effectively harnessing and transforming triplet excitons. Further exploration of their synthesis strategies and modulation methods for performance would be valuable in advancing the field of luminescence materials. In this review, the synthesis strategy, performance optimization, and research progress of metal complexes, clusters, and coordination polymers (CPs) with PL and TADF properties are summarized in detail. Moreover, leveraging the effective utilization of triplet excitons, these materials’ applications in photoelectric devices, information encryptions scintillators, sensing technologies, photocatalysis, and biological fields are also discussed.

Owing to their elemental abundance and unique bandgap, ternary transition metal chalcogenides (TMCs) have recently attracted significant attention from researchers. Among various TMCs, Cu₂MX₄ (M = Mo, and W; X = S, and Se, shortly denoted as CMX) species possess distinct advantages, such as tunable chemical composition, resultant diverse morphologies (structure, size, and shape), excellent biocompatibility, exceptional degradability, unique catalytic performance, and considerable in vivo elimination. Considering these outstanding morphological attributes and desirable physicochemical features, this article explicitly reviews recent advancements and the latest breakthroughs of different CMX-based nanoarchitectures for biomedicine. Initially, we discuss the chemistry and relevant properties offered by elements in the composites. Then, a brief note is given on different CMX-based nanoarchitectures. Further, we present various synthesis strategies for generating different structures, highlighting their altered morphology and the factors affecting various formulation parameters. Further, the possible effects offered by these CMX-based nanoarchitectures are explored in different fields of biomedicine. Finally, we summarize the article with an interesting outlook on their clinical translation.