Pub Date : 2025-02-18DOI: 10.1016/j.ccr.2025.216527
Anurag Gautam , Pragya Komal
To cure and extend life, it is essential to overcome age-related non-communicable disorders such as cancer, Alzheimer's disease, Huntington's disease, and Parkinson's disease in a shorter span of time. In this regard, the multimodal imaging technique can play a crucial role because it would significantly reduce the amount of drug needed for a patient by reducing the number of steps involved in a diagnosis. Additionally, it will provide a more accurate and precise diagnosis because the drawbacks of one particular modality can be overcome by complementary modality in a combined diagnosis instrument. This review discusses the commercially available MRI contrast agents and bimodal multimodal MRI-routed imaging with lanthanide-based nanoparticles (NPs), such as Optical/MRI, CT/MRI, and SPECT/MRI. Additionally, we also have discussed the progress of their multimodal imaging.
{"title":"Diagnosis of neurological and non-neurological disorders via bimodal/multimodal imaging with lanthanide based nanoparticles","authors":"Anurag Gautam , Pragya Komal","doi":"10.1016/j.ccr.2025.216527","DOIUrl":"10.1016/j.ccr.2025.216527","url":null,"abstract":"<div><div>To cure and extend life, it is essential to overcome age-related non-communicable disorders such as cancer, Alzheimer's disease, Huntington's disease, and Parkinson's disease in a shorter span of time. In this regard, the multimodal imaging technique can play a crucial role because it would significantly reduce the amount of drug needed for a patient by reducing the number of steps involved in a diagnosis. Additionally, it will provide a more accurate and precise diagnosis because the drawbacks of one particular modality can be overcome by complementary modality in a combined diagnosis instrument. This review discusses the commercially available MRI contrast agents and bimodal multimodal MRI-routed imaging with lanthanide-based nanoparticles (NPs), such as Optical/MRI, CT/MRI, and SPECT/MRI. Additionally, we also have discussed the progress of their multimodal imaging.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"532 ","pages":"Article 216527"},"PeriodicalIF":20.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Early detection and diagnosis of pathologies is an essential part of clinical practice. This continually drives improvements in imaging modalities and contrast agents. The challenge is always to obtain the most accurate images possible of lesions, but also to detect tissue microstructures or metabolic events. This means combining resolution and sensitivity with deep-tissue imaging. Here, we review examples of contrast agents used in the various biomedical imaging modalities currently in use (CT, US, MRI, SPECT, PET, Fluorescence). We will then take a closer look at photoacoustic imaging (PAI), because of its intrinsic resolution and sensitivity. The review is structured as follows: first, the principle of each technique is discussed, followed by a description of the characteristics that the dedicated contrast agents must meet. Third, recent examples of molecular and nanoparticulate contrast agents will be described. Finally, a special section will be devoted to bimodal contrast agents combining MRI and PAI imaging, showing that it is a very promising tandem.
{"title":"Contrast enhancement in medical imaging: At the crossroads of techniques and contrast agents – Improvements over the last decade","authors":"Camille Gosée , Cyril Cadiou , Juliette Moreau , Maité Callewaert , Christelle Kowandy , Céline Henoumont , Lionel Larbanoix , Sophie Laurent , Françoise Chuburu","doi":"10.1016/j.ccr.2025.216523","DOIUrl":"10.1016/j.ccr.2025.216523","url":null,"abstract":"<div><div>Early detection and diagnosis of pathologies is an essential part of clinical practice. This continually drives improvements in imaging modalities and contrast agents. The challenge is always to obtain the most accurate images possible of lesions, but also to detect tissue microstructures or metabolic events. This means combining resolution and sensitivity with deep-tissue imaging. Here, we review examples of contrast agents used in the various biomedical imaging modalities currently in use (CT, US, MRI, SPECT, PET, Fluorescence). We will then take a closer look at photoacoustic imaging (PAI), because of its intrinsic resolution and sensitivity. The review is structured as follows: first, the principle of each technique is discussed, followed by a description of the characteristics that the dedicated contrast agents must meet. Third, recent examples of molecular and nanoparticulate contrast agents will be described. Finally, a special section will be devoted to bimodal contrast agents combining MRI and PAI imaging, showing that it is a very promising tandem.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"532 ","pages":"Article 216523"},"PeriodicalIF":20.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1016/j.ccr.2025.216509
Muthu Devaraj, Xuehua Zhou
The gradual increase of volatile organic compounds (VOCs) and CO2 create serious environmental and health complications. Therefore, the abatement of VOCs and the conversion of CO2 into solar chemicals/fuels through photocatalysis technique have been receiving more attention from the research community. Considerable progresses have been made in the development of semiconductor-based photocatalysts, where selecting efficient, economical, stable and environmentally beneficial photocatalysts is crucial. In recent decades, exploring layered double hydroxides (LDHs)-based materials as potential catalysts has become an attractive research topic because LDHs are versatile, adaptable semiconducting materials suitable for heterogeneous catalysis to meet growing demands. In addition to their unique two dimensional (2D) layered structure, exchangeable interlayer anions, adjustable metal composition and tuneable physicochemical, electrical and optical properties, LDHs serve as excellent starting points for developing a variety of bimetallic products through post-synthesis modifications. This review provides an overview of recent advancements in LDHs-based photocatalysts for VOCs abatement and CO2 reduction. It begins with an overview of LDHs and photocatalytic theory, followed by a discussion of the photooxidation of VOCs and the selection of LDHs and LDHs-based photocatalysts for VOCs abatement. Furthermore, it addresses the environmental and industrial significance of CO2 reduction, the fundamentals of CO2 photoreduction, LDHs-based materials (including metal cations and anions tunability, morphology, noble metals, defect engineering and heterogeneous materials) for CO2 photoreduction, C2+ products formation and achieving efficiency and selectivity in LDHs-based catalysts. Moreover, the stability of LDHs-based heterostructure photocatalysts along with their scalability and associated scientific challenges are discussed. Finally, the review offers new insights into the main obstacles, prospects and perspectives for further study in the developing field. It is evident that innovative LDHs-based materials have the potential to serve as highly effective photocatalysts and potentially lead to significant advances in VOCs and CO2 photoreduction.
{"title":"Recent advances in photocatalytic performances of layered double hydroxides-based materials for VOCs and CO2 mitigation: A comprehensive review","authors":"Muthu Devaraj, Xuehua Zhou","doi":"10.1016/j.ccr.2025.216509","DOIUrl":"10.1016/j.ccr.2025.216509","url":null,"abstract":"<div><div>The gradual increase of volatile organic compounds (VOCs) and CO<sub>2</sub> create serious environmental and health complications. Therefore, the abatement of VOCs and the conversion of CO<sub>2</sub> into solar chemicals/fuels through photocatalysis technique have been receiving more attention from the research community. Considerable progresses have been made in the development of semiconductor-based photocatalysts, where selecting efficient, economical, stable and environmentally beneficial photocatalysts is crucial. In recent decades, exploring layered double hydroxides (LDHs)-based materials as potential catalysts has become an attractive research topic because LDHs are versatile, adaptable semiconducting materials suitable for heterogeneous catalysis to meet growing demands. In addition to their unique two dimensional (2D) layered structure, exchangeable interlayer anions, adjustable metal composition and tuneable physicochemical, electrical and optical properties, LDHs serve as excellent starting points for developing a variety of bimetallic products through post-synthesis modifications. This review provides an overview of recent advancements in LDHs-based photocatalysts for VOCs abatement and CO<sub>2</sub> reduction. It begins with an overview of LDHs and photocatalytic theory, followed by a discussion of the photooxidation of VOCs and the selection of LDHs and LDHs-based photocatalysts for VOCs abatement. Furthermore, it addresses the environmental and industrial significance of CO<sub>2</sub> reduction, the fundamentals of CO<sub>2</sub> photoreduction, LDHs-based materials (including metal cations and anions tunability, morphology, noble metals, defect engineering and heterogeneous materials) for CO<sub>2</sub> photoreduction, C2+ products formation and achieving efficiency and selectivity in LDHs-based catalysts. Moreover, the stability of LDHs-based heterostructure photocatalysts along with their scalability and associated scientific challenges are discussed. Finally, the review offers new insights into the main obstacles, prospects and perspectives for further study in the developing field. It is evident that innovative LDHs-based materials have the potential to serve as highly effective photocatalysts and potentially lead to significant advances in VOCs and CO<sub>2</sub> photoreduction.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"532 ","pages":"Article 216509"},"PeriodicalIF":20.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The CO selective catalytic reduction of NOx (CO-SCR) is considered an effective denitrification technology that can concurrently eliminate the harmful gases of NOx and CO. Co-based catalysts have been widely researched because of their exceptional adsorption and activation capabilities for CO and NOx, but their catalytic efficiency is frequently compromised by the presence of O2, SO2, and H2O, which necessitates enhancements in long-term stability. This review presents various synthesis approaches of Co-based catalysts, summarizes the correlation between their valence states, particle sizes, oxygen vacancies, and catalytic performance, and examines the impacts of O2, H2O, and SO2 on the CO-SCR process. Subsequently, the catalytic mechanisms of different Co-based catalysts are thoroughly detailed. Lastly, this review offers potential directions for the development of high-efficiency Co-based catalysts. The aim of this work is to provide theoretical guidance for the rational design of more effective Co-based catalysts for the CO-SCR reaction in industrial settings.
{"title":"Co-based catalysts for the reduction of NOx with CO via the regulation of geometric and electronic structure","authors":"Botao Liu, Guiyao Dai, Ruijing Wang, Huanli Wang, Yaxin Miao, Shujun Hou, Dianxing Lian, Mohaoyang Chen, Chenxi Li, Ke Wu, Weiwei Zhang, Yongjun Ji","doi":"10.1016/j.ccr.2025.216502","DOIUrl":"10.1016/j.ccr.2025.216502","url":null,"abstract":"<div><div>The CO selective catalytic reduction of NO<sub>x</sub> (CO-SCR) is considered an effective denitrification technology that can concurrently eliminate the harmful gases of NO<sub>x</sub> and CO. Co-based catalysts have been widely researched because of their exceptional adsorption and activation capabilities for CO and NO<sub>x</sub>, but their catalytic efficiency is frequently compromised by the presence of O<sub>2</sub>, SO<sub>2</sub>, and H<sub>2</sub>O, which necessitates enhancements in long-term stability. This review presents various synthesis approaches of Co-based catalysts, summarizes the correlation between their valence states, particle sizes, oxygen vacancies, and catalytic performance, and examines the impacts of O<sub>2</sub>, H<sub>2</sub>O, and SO<sub>2</sub> on the CO-SCR process. Subsequently, the catalytic mechanisms of different Co-based catalysts are thoroughly detailed. Lastly, this review offers potential directions for the development of high-efficiency Co-based catalysts. The aim of this work is to provide theoretical guidance for the rational design of more effective Co-based catalysts for the CO-SCR reaction in industrial settings.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"532 ","pages":"Article 216502"},"PeriodicalIF":20.3,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-17DOI: 10.1016/j.ccr.2025.216508
Luoming Liu , Kun Hou , Siyu Lin , Yaoxuan Di , Zhulun Zhuang , Ziyuan Zeng , Ying Sun , Chong Ji , Chaobo Huang , Ranhua Xiong
Oxygen is essential for biological metabolism. However, due to shortages in clinical surgeries, blood group incompatibilities, and the risk of infection transmission, there is an urgent need for a safe and efficient oxygen carrier to replace whole blood. Advances in biotechnology have led to the development of an oxygen carrier based on stroma-free hemoglobin (SFH), which has garnered significant interest because of its excellent biosafety profile and diverse sources. This review first introducing the structure of hemoglobin (Hb) and then classifies the membrane-free Hb-based oxygen carriers (HBOCs) based on chemical and genetic modifications of Hb. Additionally, the membrane-encapsulated HBOCs is categorized by the type of material used such as liposomes, polymers, metal-organ frameworks (MOFs), hydrogel and polysaccharide, and its advantages and disadvantages, as well as its suitability as an oxygen carrier, are analyzed. Furthermore, the application of the HBOCs in biomedicine is discussed. Finally, the remaining challenges and future prospects are examined. These innovative oxygen carriers offer significant advantages over traditional carriers and are poised to substantially advance research into practical and reliable oxygen carriers.
{"title":"Hemoglobin based oxygen carrier and its application in biomedicine","authors":"Luoming Liu , Kun Hou , Siyu Lin , Yaoxuan Di , Zhulun Zhuang , Ziyuan Zeng , Ying Sun , Chong Ji , Chaobo Huang , Ranhua Xiong","doi":"10.1016/j.ccr.2025.216508","DOIUrl":"10.1016/j.ccr.2025.216508","url":null,"abstract":"<div><div>Oxygen is essential for biological metabolism. However, due to shortages in clinical surgeries, blood group incompatibilities, and the risk of infection transmission, there is an urgent need for a safe and efficient oxygen carrier to replace whole blood. Advances in biotechnology have led to the development of an oxygen carrier based on stroma-free hemoglobin (SFH), which has garnered significant interest because of its excellent biosafety profile and diverse sources. This review first introducing the structure of hemoglobin (Hb) and then classifies the membrane-free Hb-based oxygen carriers (HBOCs) based on chemical and genetic modifications of Hb. Additionally, the membrane-encapsulated HBOCs is categorized by the type of material used such as liposomes, polymers, metal-organ frameworks (MOFs), hydrogel and polysaccharide, and its advantages and disadvantages, as well as its suitability as an oxygen carrier, are analyzed. Furthermore, the application of the HBOCs in biomedicine is discussed. Finally, the remaining challenges and future prospects are examined. These innovative oxygen carriers offer significant advantages over traditional carriers and are poised to substantially advance research into practical and reliable oxygen carriers.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"532 ","pages":"Article 216508"},"PeriodicalIF":20.3,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1016/j.ccr.2025.216491
Madison R. Esposito , Rajashree Newar , Min Kim , Seth M. Cohen
Despite the prevalence of low-valent metal complexes and their critical role in processes such as catalysis, luminescence, etc., the use of low-valent metals as structural components of metal-organic frameworks (MOFs) is surprisingly rare. Typical MOFs rely on the interaction of hard, Lewis basic multitopic ligands (such as carboxylates) with hard Lewis acidic high-valent metal ions for framework construction. By contrast, low-valent metal-organic frameworks (LVMOFs) are constructed from soft Lewis basic ligands with metals in their (0) or (+1) oxidation states. The relatively rare instances of LVMOFs have been investigated for a variety of applications, particularly as heterogeneous catalysts for small molecule transformations. Beyond LVMOFs, strategies such as postsynthetic modification (PSM) have also been used to incorporate low-valent metals into canonical MOFs. In this review, the development of LVMOFs and related materials, namely low-valent, one-dimensional coordination polymers (CPs) are presented. In addition, MOFs with low-valent metals incorporated via PSM are also discussed.
{"title":"Incorporation of low-valent metal ions in metal-organic frameworks and coordination polymers","authors":"Madison R. Esposito , Rajashree Newar , Min Kim , Seth M. Cohen","doi":"10.1016/j.ccr.2025.216491","DOIUrl":"10.1016/j.ccr.2025.216491","url":null,"abstract":"<div><div>Despite the prevalence of low-valent metal complexes and their critical role in processes such as catalysis, luminescence, etc., the use of low-valent metals as structural components of metal-organic frameworks (MOFs) is surprisingly rare. Typical MOFs rely on the interaction of hard, Lewis basic multitopic ligands (such as carboxylates) with hard Lewis acidic high-valent metal ions for framework construction. By contrast, low-valent metal-organic frameworks (LVMOFs) are constructed from soft Lewis basic ligands with metals in their (0) or (+1) oxidation states. The relatively rare instances of LVMOFs have been investigated for a variety of applications, particularly as heterogeneous catalysts for small molecule transformations. Beyond LVMOFs, strategies such as postsynthetic modification (PSM) have also been used to incorporate low-valent metals into canonical MOFs. In this review, the development of LVMOFs and related materials, namely low-valent, one-dimensional coordination polymers (CPs) are presented. In addition, MOFs with low-valent metals incorporated via PSM are also discussed.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"531 ","pages":"Article 216491"},"PeriodicalIF":20.3,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1016/j.ccr.2025.216496
Chengchao He , Duo Pan , Xin Li , Zhiwen Lu , Kai Chen , GenXiang Wang , Zhifang Zhang , Hao Zhang , Yu Zhang , Zhenhai Wen
High-entropy materials (HEMs), especially high-entropy alloys (HEAs) and various metal-based compounds, are emerging in the field of electrocatalysis due to their characteristics of “out of disorder comes order”, high-entropy mixing effect, and unique physical and chemical properties. HEMs are a unique multi-element principal component material. Its notable characteristic lies in its diverse array of constituent elements, with their proportions being evenly dispersed, typically in an exact or nearly equal molar ratio. Such materials cover HEAs and a range of high-entropy compounds, such as high-entropy oxides, hydroxides, phosphides, and sulfides. Recent years have witnessed a surge in research exploring the synthesis and catalytic applications of these innovative materials, leading to a number of reviewing articles that have overviewed various aspects of HEMs, this work distinguishes itself by offering fresh perspectives and insights into the most recent advancements, particularly focusing on emerging trends and innovations. The review offers fresh perspectives and insights into the latest advancements in the field that have not been comprehensively covered before, with a focus on emerging synthesis methods, innovative design strategies, cutting-edge characterization techniques, theoretical predictions, and catalytic applications of HEMs. Additionally, the evolving role of density functional theory (DFT) in the theoretical design and high-throughput screening of HEM electrocatalysts is explored in greater depth, providing a unique angle on their theoretical underpinnings. Progress in applying HEMs to a variety of electrochemical catalytic reactions is revisited with a focus on the latest breakthroughs. Finally, the review critically examines the current challenges and future developments for HEMs, offering new insights into their emerging potential in catalysis, thereby setting this work apart from prior articles in the field.
{"title":"Fresh perspectives and insights into the challenges and opportunities in the emerging high-entropy electrocatalysts","authors":"Chengchao He , Duo Pan , Xin Li , Zhiwen Lu , Kai Chen , GenXiang Wang , Zhifang Zhang , Hao Zhang , Yu Zhang , Zhenhai Wen","doi":"10.1016/j.ccr.2025.216496","DOIUrl":"10.1016/j.ccr.2025.216496","url":null,"abstract":"<div><div>High-entropy materials (HEMs), especially high-entropy alloys (HEAs) and various metal-based compounds, are emerging in the field of electrocatalysis due to their characteristics of “out of disorder comes order”, high-entropy mixing effect, and unique physical and chemical properties. HEMs are a unique multi-element principal component material. Its notable characteristic lies in its diverse array of constituent elements, with their proportions being evenly dispersed, typically in an exact or nearly equal molar ratio. Such materials cover HEAs and a range of high-entropy compounds, such as high-entropy oxides, hydroxides, phosphides, and sulfides. Recent years have witnessed a surge in research exploring the synthesis and catalytic applications of these innovative materials, leading to a number of reviewing articles that have overviewed various aspects of HEMs, this work distinguishes itself by offering fresh perspectives and insights into the most recent advancements, particularly focusing on emerging trends and innovations. The review offers fresh perspectives and insights into the latest advancements in the field that have not been comprehensively covered before, with a focus on emerging synthesis methods, innovative design strategies, cutting-edge characterization techniques, theoretical predictions, and catalytic applications of HEMs. Additionally, the evolving role of density functional theory (DFT) in the theoretical design and high-throughput screening of HEM electrocatalysts is explored in greater depth, providing a unique angle on their theoretical underpinnings. Progress in applying HEMs to a variety of electrochemical catalytic reactions is revisited with a focus on the latest breakthroughs. Finally, the review critically examines the current challenges and future developments for HEMs, offering new insights into their emerging potential in catalysis, thereby setting this work apart from prior articles in the field.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"531 ","pages":"Article 216496"},"PeriodicalIF":20.3,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1016/j.ccr.2025.216519
Pravin D. Patil , Niharika Gargate , Manishkumar S. Tiwari , Shamraja S. Nadar
The field of metal-organic frameworks (MOFs) for enzyme immobilization has gained significant traction due to their versatile structural properties and exceptional stability. There are certain constraints after enzyme-MOF composite formation, such as (i) reduction in enzyme activity, (ii) mass transfer limitation between substrate-enzyme, and (iii) unfavorable micro-environment for immobilized enzyme within MOF. Therefore, the defects in MOFs have emerged as a powerful tool to enhance the enzyme catalytic properties and their loading. This review delves into the recent advancements in defect engineering of MOFs, elucidating the role of structural defects in creating mesoporous environments that facilitate superior enzyme immobilization and activity. The synthesis strategies, such as post-synthetic and de-novo methods for controlled defect formation, are comprehensively discussed. Moreover, the integration of machine learning approaches for predicting and optimizing D-MOFs is highlighted, showcasing their transformative impact on biocatalytic applications. The challenges related to synthesis, characterization, enzyme microenvironment, separation, and recycling are critically examined, focusing on the future scope of defect MOFs in sustainable and scalable biocatalysis. This review underscores the untapped potential of defect engineering in MOFs to revolutionize enzyme immobilization, paving the way for innovative biocatalytic processes and applications.
{"title":"Defect metal-organic frameworks (D-MOFs): An engineered nanomaterial for enzyme immobilization","authors":"Pravin D. Patil , Niharika Gargate , Manishkumar S. Tiwari , Shamraja S. Nadar","doi":"10.1016/j.ccr.2025.216519","DOIUrl":"10.1016/j.ccr.2025.216519","url":null,"abstract":"<div><div>The field of metal-organic frameworks (MOFs) for enzyme immobilization has gained significant traction due to their versatile structural properties and exceptional stability. There are certain constraints after enzyme-MOF composite formation, such as (i) reduction in enzyme activity, (ii) mass transfer limitation between substrate-enzyme, and (iii) unfavorable micro-environment for immobilized enzyme within MOF. Therefore, the defects in MOFs have emerged as a powerful tool to enhance the enzyme catalytic properties and their loading. This review delves into the recent advancements in defect engineering of MOFs, elucidating the role of structural defects in creating mesoporous environments that facilitate superior enzyme immobilization and activity. The synthesis strategies, such as post-synthetic and <em>de-novo</em> methods for controlled defect formation, are comprehensively discussed. Moreover, the integration of machine learning approaches for predicting and optimizing D-MOFs is highlighted, showcasing their transformative impact on biocatalytic applications. The challenges related to synthesis, characterization, enzyme microenvironment, separation, and recycling are critically examined, focusing on the future scope of defect MOFs in sustainable and scalable biocatalysis. This review underscores the untapped potential of defect engineering in MOFs to revolutionize enzyme immobilization, paving the way for innovative biocatalytic processes and applications.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"531 ","pages":"Article 216519"},"PeriodicalIF":20.3,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-12DOI: 10.1016/j.ccr.2025.216520
Xuan Wang , Rongyan Wan , Yunqian Tang , Shuoyun Sun , Hong Chen , Linsen Li , Jianling Chen , Jinchao Wei , Zhenguo Chi , Haiyin Li
Design and development of electrochemiluminescence (ECL) sensors with high sensitivity and selectivity for analytes quantitative detection plays an important role in monitoring food/environmental safety and preserving human health. Aggregation-induced emission (AIE) materials feature higher luminescence in aggregated state than in dissolved state and hence are considered as ideal emitters to develop high-performance ECL sensors. Enlightened by this, researchers around the world have made considerable efforts to devise and synthesize AIE materials with unique ECL performance for reliably analyzing disease biomarkers and toxic substances with high sensitivity. In this review, we outline the recent advances on devise and preparation of AIE materials with different components exhibiting unique ECL property, and development of AIE materials-based ECL sensors for sensitive detection of nucleic acids, proteins, amino acids, metal ions, anions, etc. Further, the confronting hurdles and perspectives on the future of such ECL sensors were briefly discussed to give the researchers a little inspiration for developing higher-performance sensors. Moreover, we hope this overview will not only facilitate the huge progress of AIE materials-based ECL sensors, but also boost the commercial application in real-life scenarios in the future, truly serving the general public.
{"title":"Aggregation-induced emission materials-based Electrochemiluminescence emitters for sensing applications: Progress, challenges and perspectives","authors":"Xuan Wang , Rongyan Wan , Yunqian Tang , Shuoyun Sun , Hong Chen , Linsen Li , Jianling Chen , Jinchao Wei , Zhenguo Chi , Haiyin Li","doi":"10.1016/j.ccr.2025.216520","DOIUrl":"10.1016/j.ccr.2025.216520","url":null,"abstract":"<div><div>Design and development of electrochemiluminescence (ECL) sensors with high sensitivity and selectivity for analytes quantitative detection plays an important role in monitoring food/environmental safety and preserving human health. Aggregation-induced emission (AIE) materials feature higher luminescence in aggregated state than in dissolved state and hence are considered as ideal emitters to develop high-performance ECL sensors. Enlightened by this, researchers around the world have made considerable efforts to devise and synthesize AIE materials with unique ECL performance for reliably analyzing disease biomarkers and toxic substances with high sensitivity. In this review, we outline the recent advances on devise and preparation of AIE materials with different components exhibiting unique ECL property, and development of AIE materials-based ECL sensors for sensitive detection of nucleic acids, proteins, amino acids, metal ions, anions, etc. Further, the confronting hurdles and perspectives on the future of such ECL sensors were briefly discussed to give the researchers a little inspiration for developing higher-performance sensors. Moreover, we hope this overview will not only facilitate the huge progress of AIE materials-based ECL sensors, but also boost the commercial application in real-life scenarios in the future, truly serving the general public.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"531 ","pages":"Article 216520"},"PeriodicalIF":20.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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