Volumetric and functional connectivity changes of the thalamic nuclei in different stages of Alzheimer’s disease

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-07-09 DOI:10.1016/j.clinph.2024.06.018

Emre Hari , Cigdem Ulasoglu-Yildiz , Elif Kurt , Ali Bayram , Hakan Gurvit , Tamer Demiralp

{"title":"Volumetric and functional connectivity changes of the thalamic nuclei in different stages of Alzheimer’s disease","authors":"Emre Hari , Cigdem Ulasoglu-Yildiz , Elif Kurt , Ali Bayram , Hakan Gurvit , Tamer Demiralp","doi":"10.1016/j.clinph.2024.06.018","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Memory processes known to be impaired in Alzheimer’s disease (AD) are maintained by a large-scale neurocognitive network with subcortical components, including the thalamus. Therefore, we aimed to examine the volumetric and functional changes of the thalamic nuclei at different scales across AD stages.</p></div><div><h3>Methods</h3><p>MRI data of patients diagnosed with 20 AD dementia (ADD), 30 amnestic mild cognitive impairment (MCI), and 30 subjective cognitive impairment (SCI) were used. Volumetric and functional connectivity analyzes were performed by dividing the thalamus into anterior, medial, posterior, lateral and intralaminar nucleus groups and their specific subnuclei.</p></div><div><h3>Results</h3><p>In the course of AD, the volume of the medial group nuclei, especially the mediodorsal medial magnocellular (MDm) nucleus, decreases. Medial group nuclei and MDm functional connectivity with frontal areas were decreased both in ADD and MCI compared to SCI group, while both of them increased their functional connectivity with visual areas in the ADD group compared to the MCI group.</p></div><div><h3>Conclusions</h3><p>Our study suggests that the medial group of the thalamus, and specifically the MDm, may be affected in AD.</p></div><div><h3>Significance</h3><p>Specific thalamic nuclei may be a critical anatomical region for investigating structural and functional changes in AD.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"165 ","pages":"Pages 127-137"},"PeriodicalIF":3.7000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1388245724002013","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Memory processes known to be impaired in Alzheimer’s disease (AD) are maintained by a large-scale neurocognitive network with subcortical components, including the thalamus. Therefore, we aimed to examine the volumetric and functional changes of the thalamic nuclei at different scales across AD stages.

Methods

MRI data of patients diagnosed with 20 AD dementia (ADD), 30 amnestic mild cognitive impairment (MCI), and 30 subjective cognitive impairment (SCI) were used. Volumetric and functional connectivity analyzes were performed by dividing the thalamus into anterior, medial, posterior, lateral and intralaminar nucleus groups and their specific subnuclei.

Results

In the course of AD, the volume of the medial group nuclei, especially the mediodorsal medial magnocellular (MDm) nucleus, decreases. Medial group nuclei and MDm functional connectivity with frontal areas were decreased both in ADD and MCI compared to SCI group, while both of them increased their functional connectivity with visual areas in the ADD group compared to the MCI group.

Conclusions

Our study suggests that the medial group of the thalamus, and specifically the MDm, may be affected in AD.

Significance

Specific thalamic nuclei may be a critical anatomical region for investigating structural and functional changes in AD.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

阿尔茨海默病不同阶段丘脑核的体积和功能连接变化

目的已知阿尔茨海默病（AD）中受损的记忆过程是由包括丘脑在内的皮层下成分组成的大规模神经认知网络维持的。因此，我们旨在研究丘脑核团在 AD 不同阶段不同尺度上的体积和功能变化。方法我们使用了 20 例 AD 痴呆（ADD）、30 例失忆性轻度认知障碍（MCI）和 30 例主观认知障碍（SCI）患者的 MRI 数据。通过将丘脑分为前核、内侧核、后核、外侧核和椎板内侧核群及其特定亚核，对丘脑的体积和功能连接性进行了分析。结论我们的研究表明，丘脑内侧核团，特别是 MDm，可能在 AD 中受到影响。意义特定丘脑核团可能是研究 AD 结构和功能变化的关键解剖区域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.