A renaissance of cerebral cavernous malformation proteins in vascular physiology

IF 9.4 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Nature cardiovascular research Pub Date : 2024-06-27 DOI:10.1038/s44161-024-00504-1
Salim Abdelilah-Seyfried, Hanjoong Jo
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Abstract

The discovery of the genes causing cerebral cavernous malformation (CCM) initially heralded a fruitful search for etiopathogenic molecular pathways in this rare cerebrovascular disease. Recent studies have identified the relevance of CCM proteins for much more common vascular biology and pathologies.

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脑海绵畸形蛋白在血管生理学中的复兴
脑海绵畸形(CCM)致病基因的发现,最初预示着对这种罕见脑血管疾病致病分子途径的探索将取得丰硕成果。最近的研究发现,CCM 蛋白与更常见的血管生物学和病理学相关。
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