Impact of Delta Troponin on Short-Term Mortality in Patients with Chronic Renal Dysfunction and NSTEMI

Burak Acem, S. Eroğlu, Serdar Özdemir
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Abstract

Introduction The relationship between mortality and troponin in non-ST-elevation myocardial infarction (NSTEMI) patients with a history of renal failure is quite limited. This study investigated the relationship between blood delta troponin T levels and 30-day mortality in patients with chronic renal dysfunction and NSTEMI. Materials and Methods This study was conducted prospectively by including patients with chronic renal dysfunction and clinical findings of NSTEMI between February 1, 2021, and August 1, 2022. Demographics, medical history, laboratory parameters, and mortality data were noted. Thirty-day morbidity data was used for mortality. Delta troponin T was calculated using initial and first-hour troponin T values. Patients were grouped as healthy and deceased. Data were evaluated using univariant analysis and receiver operating characteristics analysis. Results Of the 73 patients included in the study, 29 were female. The mean age of the patients was 67.3 years. The 30-day mortality rate was 9.5%. The sensitivity of the initial troponin T value was 85.7% (42.1–99.6), the specificity was 68.2% (55.6–79.1), and the accuracy was 69.9% (58–80.1), and the sensitivity of the first-hour troponin T value was 85.7% (42.1–99.6), specificity was 75.8% (63.6–85.5), and accuracy was 76.7% (65.4–85.8). The delta troponin T median of the mortality group was 56 (24.2–286.4), and the delta troponin median of the surviving patients was 29.4 (10.7–79.6). The difference was not statistically significant (p = 0.072). Conclusion The current study's results show that delta troponin T (initial and first hour) is not associated with short-term mortality in patients with chronic renal dysfunction and NSTEMI.
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δ肌钙蛋白对慢性肾功能障碍和 NSTEMI 患者短期死亡率的影响
导言:有肾功能衰竭病史的非 ST 段抬高型心肌梗死(NSTEMI)患者的死亡率与肌钙蛋白之间的关系非常有限。本研究调查了慢性肾功能不全和 NSTEMI 患者的血液δ肌钙蛋白 T 水平与 30 天死亡率之间的关系。材料与方法 本研究采用前瞻性研究方法,纳入了 2021 年 2 月 1 日至 2022 年 8 月 1 日期间患有慢性肾功能不全并临床发现为 NSTEMI 的患者。研究人员记录了患者的人口统计学特征、病史、实验室参数和死亡率数据。死亡率采用 30 天发病率数据。使用初始值和第一小时肌钙蛋白 T 值计算Δ肌钙蛋白 T。患者分为健康和死亡两组。采用单变量分析和接收者操作特征分析对数据进行评估。结果 在纳入研究的 73 名患者中,有 29 名女性。患者的平均年龄为 67.3 岁。30 天死亡率为 9.5%。初始肌钙蛋白 T 值的灵敏度为 85.7%(42.1-99.6),特异性为 68.2%(55.6-79.1),准确性为 69.9%(58-80.1);第一小时肌钙蛋白 T 值的灵敏度为 85.7%(42.1-99.6),特异性为 75.8%(63.6-85.5),准确性为 76.7%(65.4-85.8)。死亡组的δ肌钙蛋白 T 中位数为 56(24.2-286.4),而存活患者的δ肌钙蛋白中位数为 29.4(10.7-79.6)。差异无统计学意义(P = 0.072)。结论 目前的研究结果表明,δ肌钙蛋白 T(初始和第一小时)与慢性肾功能不全和 NSTEMI 患者的短期死亡率无关。
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