Synthesis of Strontium Substituted Hydroxyapatite Coating on Titanium Via Hydrothermal Method

Le Thi Tam, Vu Dao Kien, Ta Quoc Tuan, Le Van Toan, Pham Thi Mai Phuong, Pham Hung Vuong
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Abstract

In this study, strontium substituted hydroxyapatite (SrHA) was successfully deposited onto etched titanium substrates in H2SO4 and HCl solution. The deposition was achieved by hydrothermal method by immersing the substrates in a solution containing Ca(NO3)2.4H2O, NH4H2PO4, and 5% Sr(NO3)2, followed by heating at 200°C for 12 hours. X-ray diffraction (XRD) analysis confirmed that all SrHA coatings exhibited a crystalline hydroxyapatite structure. Field-emission scanning electron microscopy (FE-SEM) revealed that the microstructure of the SrHA coatings exhibited. Bioactivity and in vitro biocompatibility testing of the SrHA-coated titanium substrates using SBF solution and baby hamster kidney (BHK) cells demonstrated positive results.      
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通过水热法在钛上合成锶取代羟基磷灰石涂层
本研究成功地在 H2SO4 和 HCl 溶液中将锶取代羟基磷灰石(SrHA)沉积到蚀刻钛基板上。沉积是通过水热法实现的,方法是将基底浸入含有 Ca(NO3)2.4H2O、NH4H2PO4 和 5% Sr(NO3)2 的溶液中,然后在 200°C 下加热 12 小时。X 射线衍射 (XRD) 分析证实,所有 SrHA 涂层都呈现出羟基磷灰石结晶结构。场发射扫描电子显微镜(FE-SEM)显示,SrHA 涂层的微观结构具有以下特征。使用 SBF 溶液和小仓鼠肾脏 (BHK) 细胞对 SrHA 涂层钛基底进行的生物活性和体外生物相容性测试表明结果良好。
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