Eosinophilic myenteric ganglionitis: A case in a 14‐year‐old‐male

JPGN reports Pub Date : 2024-07-08 DOI:10.1002/jpr3.12108
Anthony Price, Tandis Rastegarlari, Sanober Khowaja, Kade Thompson, A. Lahiji, Michelle M. Felicella, Jing He, Annie Goodwin
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Abstract

Chronic intestinal pseudo‐obstruction (CIPO) is a rare, severe, and often debilitating condition that can result in significant morbidity and mortality amongst the pediatric population. Eosinophilic myenteric ganglionitis is a rare inflammatory neuropathy of the myenteric plexus with characteristic eosinophilic infiltration with and without hypogangliosis. The disorder has been previously documented as a cause of CIPO. We report the case of a 14‐year‐old male with no clear obstructive cause who, after multiple visits with a myriad of tests and workups, underwent surgical exploratory laparoscopy with the pathology returning a diagnosis of eosinophilic myenteric ganglionitis with unique lymphocytic and eosinophilic cell components.
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嗜酸性肠肌神经节炎:一名 14 岁男性的病例
慢性肠假性梗阻(CIPO)是一种罕见的、严重的、往往会使人衰弱的疾病,在儿科人群中可导致严重的发病率和死亡率。嗜酸性粒细胞肠肌神经节炎是一种罕见的肠肌丛炎症性神经病,具有特征性嗜酸性粒细胞浸润,伴有或不伴有神经节功能减退。以前曾有文献报道该病是 CIPO 的病因之一。我们报告了一例 14 岁男性患者的病例,他没有明确的梗阻性病因,在经过多次就诊和大量检查后,接受了外科探查性腹腔镜检查,病理结果诊断为嗜酸性粒细胞性肠系膜神经节炎,并伴有独特的淋巴细胞和嗜酸性粒细胞成分。
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