Evaluation of the Antimicrobial Activities of Some Metal (Ii) Pyrimethamine Complexes

Tasiu Dahiru, Bilya Abdu, Dauda Hassan Lamuntani
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Abstract

The research work focused on the synthesis and antimicrobial studies of complexes of Manganese (II), Cobalt (II) and Nickel (II) with 5-(-4-Chlorophenyl)-6ethylpyrimidinediamiane (pyrimethamine) which serve as ligand. The complexes were prepared by direct combination of aqueous solution of the metal ions with the solution of pyrimethamine drug in methanol. The metal complexes were then characterized by conductance measurement, determination of decomposition temperature and infrared spectral analysis. The spectral analysis shows the ligand as bidental and coordinates to the metals through the nitrogen atom of the respective amine groups. Elemental analysis shows that all the complexes have octahedral configuration [ML2CL2], Where L = Ligand and M = metal. Molar conductance measurement and decomposition temperature analysis indicate that all the complexes are stable, non-electrolytes chelates. Antimicrobial evaluation of the complexes shows varied degree of inhibitory effect against some bacterial and fungal isolates; staphylococcus aureus, escheria coli, salmonella typhi and mucor spp and Rhizopus spp. However the antimicrobial activity of Mn(II) complex was found to be greater than cobalt (II) and Nickel (II) Complexes.
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评估一些金属 (Ii) 嘧霉胺络合物的抗菌活性
研究工作的重点是锰 (II)、钴 (II) 和镍 (II) 与作为配体的 5-(-4-氯苯基)-6-乙基嘧啶二脒 (嘧霉胺) 复合物的合成和抗菌研究。这些配合物是通过将金属离子水溶液与甲醇中的嘧霉胺药物溶液直接结合而制备的。然后通过电导测量、分解温度测定和红外光谱分析对金属配合物进行了表征。光谱分析显示,配体为双价配体,通过各自胺基团的氮原子与金属配位。元素分析表明,所有配合物都具有八面体构型 [ML2CL2],其中 L = 配体,M = 金属。摩尔电导测量和分解温度分析表明,所有配合物都是稳定的非电解质螯合物。复合物的抗菌评估表明,它们对一些细菌和真菌分离物(金黄色葡萄球菌、大肠杆菌、伤寒沙门氏菌、粘菌属和根霉属)具有不同程度的抑制作用。
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