Association of ET1 and APE1 Genes Polymorphism with Coronary Artery Disease

International Journal of Angiology Pub Date : 2024-07-04 DOI:10.1055/s-0044-1788069

S. T. Raza, A. Eba, Irshad A. Wani, Sanchita Srivastava, F. Mahdi

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Abstract

Abstract Coronary artery disease (CAD) is one of the most common cardiovascular diseases (CVDs), being the foremost reason for mortality and disability globally. It is a cascade of polygenic architecture of various disorders as a resultant of complexities between various genetic factors and environmental factors. The aim of the present study was to investigate whether the ET1 and APE1 gene polymorphism is associated with the susceptibility to CAD. This study was approved by the Ethical Review Committee of Era Medical College and Hospital. Three milliliters of venous blood sample was collected in ethylenediaminetetraacetic acid-coated vials, and genomic DNA was isolated by using the standard phenol-chloroform extraction method for restriction fragment length polymorphism-polymerase chain reaction study. The APE1 gene AA, AG, GG, and AG + GG genotypes frequencies were 13.91, 40.87, 45.22, and 86.99% in CAD cases and 13, 50, 37, and 87% in controls, respectively. The ET1 gene GG, GT, TT, GT + TT genotypes frequencies were 6.67, 37.5, 55.8, and 93.34% in CAD cases and 6.67, 25.33, 68, and 93.34% in controls. The ET1 and APE1 gene polymorphisms were not significantly associated with the risk of CAD.

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ET1 和 APE1 基因多态性与冠状动脉疾病的关系

摘要冠状动脉疾病（CAD）是最常见的心血管疾病（CVDs）之一，是导致全球死亡和残疾的首要原因。由于各种遗传因素和环境因素之间的复杂性，冠状动脉疾病是一种多基因结构的连锁反应。本研究旨在探讨 ET1 和 APE1 基因多态性是否与 CAD 易感性相关。本研究已获得年代医学院和医院伦理审查委员会的批准。在涂有乙二胺四乙酸的小瓶中采集三毫升静脉血样本，采用标准苯酚-氯仿提取法分离基因组DNA，进行限制性片段长度多态性-聚合酶链反应研究。在 CAD 病例中，APE1 基因 AA、AG、GG 和 AG + GG 的基因型频率分别为 13.91%、40.87%、45.22% 和 86.99%；在对照组中，APE1 基因 AA、AG、GG 和 AG + GG 的基因型频率分别为 13%、50%、37% 和 87%。在 CAD 病例中，ET1 基因的 GG、GT、TT、GT + TT 基因型频率分别为 6.67%、37.5%、55.8% 和 93.34%；在对照组中，ET1 基因的 GG、GT、TT、GT + TT 基因型频率分别为 6.67%、25.33%、68% 和 93.34%。ET1 和 APE1 基因多态性与 CAD 风险无显著相关性。

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International Journal of Angiology

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