PET/CT with 68Ga-DOTA-TATE and 68Ga-FAPI in the Diagnosis of Neuroendocrine Tumors. Clinical Cases

E. V. Belkin, P. E. Tulin, A. Odzharova
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Abstract

Purpose: To perform a comparative analysis of diagnostic efficiency of PET/CT with 68Ga-DOTA-TATE and 68Ga-FAPI on the example of clinical cases of NEO (detection of primary tumor and extra-organ metastases).Material and methods: Two patients with pancreatic NEO underwent PET/CT studies with 68Ga-DOTA-TATE and 68Ga-FAPI before treatment. PET/CT with 68Ga-DOTA-TATE successfully visualized primary tumors in both patients; evidence of a metastatic process in the liver was obtained in one patient. PET/CT with 68Ga-FAPI showed non-optimal visualization of primary tumors, no liver metastases were detected.Conclusion: PET/CT with 68Ga-DOTA-TATE is a more effective method of radionuclide diagnostics of NEO than PET/CT with 68Ga-FAPI.
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使用 68Ga-DOTA-TATE 和 68Ga-FAPI 的 PET/CT 诊断神经内分泌肿瘤。临床病例
目的:以胰腺癌近端转移(NEO)临床病例为例,比较分析68Ga-DOTA-TATE和68Ga-FAPI PET/CT的诊断效率(检测原发肿瘤和器官外转移):材料: 两名胰腺NEO患者在治疗前接受了68Ga-DOTA-TATE和68Ga-FAPI的PET/CT检查。68Ga-DOTA-TATE正电子发射计算机断层显像/计算机断层成像成功地显示了两名患者的原发性肿瘤;一名患者获得了肝脏转移过程的证据。使用68Ga-FAPI的PET/CT显示原发肿瘤的显像效果不佳,但未发现肝转移:结论:与 68Ga-FAPI PET/CT 相比,68Ga-DOTA-TATE PET/CT 是一种更有效的近地天体放射性核素诊断方法。
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