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8th Edition AJCC/UICC Staging of Cancers of the Esophagus and Esophagogastric Junction 第 8 版 AJCC/UICC 食管和食管胃交界处癌症分期
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-76-85
O. B. Abu-Haidar, I. Gladilina, P. V. Kononets, A. A. Tryakin
Staging of cancer of the esophagus and esophagogastric junction (EGJ), presented in the 8th edition American Joint Committee on Cancer (AJCC). Cancer Staging was derived from the Worldwide Esophageal Cancer Collaboration (WECC). The 8th edition of the American Joint Committee on Cancer (AJCC) staging of the esophagus cancers and esophagogastric junction presents separate classifications for clinical (cTNM), pathologic (pTNM), and pathologic after neoadjuvant treatment (ypTNM). In this article changes presented between the 7th and 8th editions of this TNM classification. These changes included separate clinical, pathological and pathological prognostic staging for adenocarcinomas and squamous cell cancer.
食管和食管胃交界处(EGJ)癌症的分期,由第八版美国癌症联合委员会(AJCC)提出。癌症分期源自全球食管癌协作组织(WECC)。第 8 版美国癌症联合委员会(AJCC)食管癌和食管胃交界处癌症分期对临床(cTNM)、病理(pTNM)和新辅助治疗后的病理(ypTNM)进行了单独分类。本文介绍了 TNM 分类法第 7 版和第 8 版之间的变化。这些变化包括对腺癌和鳞癌分别进行临床、病理和病理预后分期。
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引用次数: 0
Tumor of the Renal Pelvis Accompanying Coral Nephrolithiasis 伴有珊瑚虫性肾炎的肾盂肿瘤
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-98-104
I. S. Grashchenko, N. T. Drobot, A. V. Klimov, O. A. Halmurzaev, S. D. Bejanova, B. Medvedeva, K. A. Romanova, E. Kolobanova, M. G. Lapteva, A. B. Lukianchenko
Cancer of the renal pelvis, in particular the squamous cell form, is an extremely rare neoplasm of this localization. Chronic inflammation is thought to be a risk factor for this disease due to the presence of stones in the collecting system. Having no specific clinical manifestations, this tumor is often an incidental finding identified during examination of patients for other reasons.This article presents a clinical case of squamous cell carcinoma of the renal pelvis in a patient with a long course of urolithiasis and the presence of staghorn stones, complicated by a kidney abscess diagnosed by CT and MRI.
肾盂癌,尤其是鳞状细胞癌,是肾盂部位极为罕见的肿瘤。由于集合系统中存在结石,慢性炎症被认为是这种疾病的一个危险因素。本文介绍了一例肾盂鳞状细胞癌的临床病例,患者患有长期尿路结石和鹿角状结石,经 CT 和 MRI 诊断并发肾脓肿。
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引用次数: 0
Primary Radiodiagnosis of Skeletal Changes in the Onset of Multiple Myeloma, Approaches to Differential Radiodiagnosis (Observations from Practice) 多发性骨髓瘤发病时骨骼变化的初级放射诊断,鉴别放射诊断的方法(实践观察)
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-55-62
A. V. Laryukov, E. K. Laryukova, F. F. Gubaidullina, Z. F. Mazitova
Multiple myeloma — Rustitzky-Kahler disease is the most common tumor of the group of Ig-secreting lymphomas. The article presents the difficulties of radiodiagnosis assessment of skeletal changes in the initial stages of multiple myeloma, when bone pain is the only clinical manifestation, and X-ray examination reveals single large foci of destruction. These observations emphasize the important role of assessment and interpretation of bone changes in such situations, which can be the main guiding factor in choosing an examination algorithm for making a correct diagnosis. The article is of interest to radiation diagnosticians, it presents literature data and issues of differential radiodiagnosis of skeletal changes in multiple myeloma.
多发性骨髓瘤--Rustitzky-Kahler 病是分泌 Ig 的淋巴瘤中最常见的肿瘤。文章介绍了放射诊断评估多发性骨髓瘤初期骨骼变化的困难之处,即骨痛是唯一的临床表现,而X光检查显示的是单个大的破坏灶。这些观察结果强调了在这种情况下评估和解释骨骼变化的重要作用,它可以成为选择检查算法以做出正确诊断的主要指导因素。文章介绍了多发性骨髓瘤骨骼病变的文献数据和放射诊断鉴别问题,对放射诊断工作者很有意义。
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引用次数: 0
Standards for the Transarterial Chemoembolization Procedure as the Hepatocellular Carcinoma Treatment: Literature Review. Part 1 经动脉化疗栓塞术治疗肝细胞癌的标准:文献综述。第一部分
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-63-75
I.  . Pogrebnyakov
The review describes the modern classification of stages of HCC, features of radiological diagnostics, the indications for morphological verification, shows the criteria for selecting patients for endovascular treatment, and outlines all the indications and contraindications for the TACE procedure. The review shows the features of preoperative preparation, describes TACE techniques for HCC, and algorithms for their implementation.
该综述介绍了 HCC 的现代分期、放射学诊断的特点、形态学验证的适应症,说明了选择患者进行血管内治疗的标准,并概述了 TACE 手术的所有适应症和禁忌症。综述介绍了术前准备的特点,描述了治疗 HCC 的 TACE 技术及其实施算法。
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引用次数: 0
PET/CT with 18F-PSMA-1007 in Diagnostics of Primary and Recurrent Lesions of Clear-cell Renal Cell Carcinoma in Comparison with 18F-FDG: Prospective Study 使用 18F-PSMA-1007 的 PET/CT 诊断透明细胞肾细胞癌的原发和复发病灶与 18F-FDG 的比较:前瞻性研究
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-15-26
V. S. Ilyakov, A. Pronin, A. V. Parnas, A. Subbotin, A. Krylov, T. Geliashvili, E. V. Bezumova, O. V. Mehedova, N. I. Nesterova, V. Matveev
Introduction: Attempts have been made to use various RPs, other than 18F-FDG in the diagnostics of renal cell carcinoma (RCC), with promising results demonstrated by PSMA-specific RPs, in particular 18F-PSMA-1007.A prospective study was conducted at N.N. Blokhin NMRCO to establish capabilities of PET/CT with 18F-FDG and 18F-PSMA-1007 in primary and recurrent ccRCC diagnostics.Material and methods: Forty-eight patients were included in the study, 28 with renal masses and 20 with suspected local recurrence of ccRCC. Biopsy results were available in all patients. All patients underwent PET/CT with 18F-PSMA-1007 and 18F-FDG.Results: Thirty-nine renal neoplasms were identified in 28 patients. 24 of 39 foci (21 patients) were PSMA-positive and 18 of 39 foci (16 patients) were FDG-positive. No false-positive foci were identified. The sensitivity, specificity, positive and negative predictive value in primary RCC were: for 18F-PSMA-1007 — 75, 100, 100 and 85 %, respectively; for 18FDG — 57, 100, 100 and 76 %, respectively. The SUVmax level of 18F-PSMA-1007 exceeded 18FDG in 27 of 28 patients (38 foci); the tumor/background ratio was higher in 16 of 28 patients (24 foci). Tumor thrombosis was detected in 6 patients (PSMA-positive 6 of 6, FDG-positive 5 of 6). PSMA-SUVmax levels in thrombi exceeded 18FDG in all patients, tumor/background ratio in 5 out of 6 patients. Local recurrence was detected in 13 of 20 patients (27 foci). 10 foci in the remaining 7 patients were considered as false positives. No false-negative results were obtained. Sensitivity, specificity, positive and negative predictive value in the diagnosis of local recurrence of ccPCC: 18F-PSMA-1007 — 100, 94, 81 and 100 %, respectively; 18FDG -100, 89, 68 and 100 %, respectively.SUVmax and tumor/background ratio were found to correlate with primary tumor and recurrent node sizes for both RPs.Discussion and conclusions: At the moment, the role of 18F-PSMA-1007 in RCC diagnostics has not been defined. We can note the high efficiency of this RP in the assessment of the primary focus and recurrence of ccRCC, its usage is justified in cases, when routine diagnostic methods do not give an unambiguous answer.The possibilities of 18F-PSMA-1007 in metastatic ccRCC diagnostics are of the greatest interest. A significant prospective material has been collected in our department, which will be the basis for further study of this RP in the diagnostics of metastatic ccRCC.
简介:N.N. Blokhin NMRCO 开展了一项前瞻性研究,以确定 PET/CT 与 18F-FDG 和 18F-PSMA-1007 在原发性和复发性 ccRCC 诊断中的作用:研究共纳入 48 例患者,其中 28 例为肾肿块患者,20 例为疑似局部复发的 ccRCC 患者。所有患者均有活检结果。所有患者均接受了 18F-PSMA-1007 和 18F-FDG PET/CT 检查:结果:28 名患者中发现了 39 个肾肿瘤。39 个病灶中有 24 个(21 名患者)为 PSMA 阳性,39 个病灶中有 18 个(16 名患者)为 FDG 阳性。未发现假阳性病灶。原发性 RCC 的敏感性、特异性、阳性预测值和阴性预测值分别为:18F-PSMA-1007 - 75%、100%、100% 和 85%;18FDG - 57%、100%、100% 和 76%。28 名患者中有 27 人(38 个病灶)的 18F-PSMA-1007 SUVmax 水平超过 18FDG;28 名患者中有 16 人(24 个病灶)的肿瘤/背景比值较高。6 例患者检测到肿瘤血栓(6 例中 PSMA 阳性 6 例,6 例中 FDG 阳性 5 例)。所有患者血栓中的 PSMA-SUVmax 水平都超过了 18FDG,6 名患者中有 5 名患者的肿瘤/背景比值超过了 18FDG。20 例患者中有 13 例(27 个病灶)发现局部复发。其余 7 名患者中的 10 个病灶被视为假阳性。没有出现假阴性结果。ccPCC局部复发诊断的敏感性、特异性、阳性预测值和阴性预测值:18F-PSMA-1007分别为100%、94%、81%和100%;18FDG分别为100%、89%、68%和100%。SUVmax和肿瘤/背景比值与两种RP的原发肿瘤和复发结节大小相关:目前,18F-PSMA-1007 在 RCC 诊断中的作用尚未明确。我们可以注意到这种 RP 在评估 ccRCC 原发灶和复发方面的高效率,在常规诊断方法无法给出明确答案的情况下,使用这种 RP 是合理的。我们科室已经收集了大量前瞻性材料,这将为进一步研究这种 RP 在诊断转移性 ccRCC 中的应用奠定基础。
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引用次数: 0
Intrapulmonary Lymph Nodes in Patients with Extrapulmonary Solid Tumors 肺外实体瘤患者的肺内淋巴结
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-46-54
V. A. Biakhova, I. E. Turin
Purpose: To clarify the possibility of metastatic lesions of intrapulmonary lymph nodes in patients with malignant neoplasms of extrapulmonary localization by analyzing retrospective and prospective material.Material and methods: Our study included 139 patients. The criterion for selecting patients was a morphologically confirmed on­cological diagnosis and the presence of lesions in the lungs. Patients were recruited from two large groups of leading localizations in the general structure of cancer incidence: a group of patients with colorectal cancer — 76 (54.7 %) and a group of patients with malignant breast tumors — 63 (45.3 %). A total of 312 lung lesions were identified and analyzed in 139 patients. High-resolution computed tomography with a slice thickness of up to 1-1.5 mm of the chest was performed in all patients. Assessment of dynamics in all patients was carried out for at least 3 years.Results: As a result, out of 139 patients with newly detected lesions in the lungs, 43 (30.9 %) patients had lesions identified, which we classified as intrapulmonary regional lymph nodes (RLNs). A total of 75 (24.0 %) lesions classified as typical or atypical RLNs were identified. We obtained the following data: RLNs were located predominantly in the lower lobes — 46.7 %, 84 % of RLNs were localized below the carina. A total of 37.3 % of lesions were classified as perifissural lesions, 62.7 % of identified lesions were classified as subpleural (peripleural) lesions. It was found that the RLNs were localized on the pleura or had a connection with it through a thin septum — 49.3 % and 38.7 %, respectively. The average diameter of the RLN in the lung was 4.0 mm. RLNs were triangular in shape in 64 %, round (lenticular) in 21.3 %, and oval in 14.7 % of cases. 96 % of the lesions we classified as RLN were monitored over time using HRCT for 3 years or more, 4 % of the lesions underwent surgical treatment. All the lesions that we observed over the course of 3 years remained without dynamics. Based on the data obtained, we concluded that RLNs in patients with solid tumors of extrapulmonary locations and lesions in the lungs are benign changes and do not require dynamic monitoring.Conclusions: Lesions in patients with solid tumors of extrapulmonary localization classified as RLN are benign changes and do not affect the stage and nature of the treatment, and also do not require dynamic monitoring.
目的:通过分析回顾性和前瞻性资料,明确肺外恶性肿瘤患者肺内淋巴结转移病变的可能性:我们的研究包括 139 名患者。选择患者的标准是经形态学确诊的肿瘤和肺部存在病变。患者来自癌症发病率总体结构中两个主要定位的大型群体:结直肠癌患者群体--76人(54.7%)和恶性乳腺肿瘤患者群体--63人(45.3%)。共发现并分析了 139 名患者的 312 处肺部病变。所有患者都接受了胸部切片厚度达 1-1.5 毫米的高分辨率计算机断层扫描。对所有患者进行了至少 3 年的动态评估:结果:在 139 例新发现肺部病变的患者中,有 43 例(30.9%)患者的病变被确定为肺内区域淋巴结 (RLN)。共有 75 个(24.0%)病灶被归类为典型或不典型区域淋巴结。我们获得了以下数据:RLNs主要位于肺下叶--占46.7%,84%的RLNs位于肺门下方。共有 37.3% 的病变被归类为乳突周围病变,62.7% 的已确定病变被归类为胸膜下(乳突周围)病变。研究发现,RLN 位于胸膜上或通过薄隔膜与胸膜相连,分别占 49.3% 和 38.7%。肺部 RLN 的平均直径为 4.0 毫米。64%的 RLN 呈三角形,21.3%呈圆形(透镜状),14.7%呈椭圆形。在我们归类为 RLN 的病灶中,96% 的病灶接受了 3 年或更长时间的 HRCT 监测,4% 的病灶接受了手术治疗。我们观察到的所有病变在 3 年内都没有发生动态变化。根据获得的数据,我们得出结论:肺外实体瘤患者的RLN和肺部病变是良性变化,不需要动态监测:肺外实体瘤患者的病变被归类为 RLN 是良性变化,不会影响治疗的阶段和性质,也不需要动态监测。
{"title":"Intrapulmonary Lymph Nodes in Patients with Extrapulmonary Solid Tumors","authors":"V. A. Biakhova, I. E. Turin","doi":"10.37174/2587-7593-2024-7-2-46-54","DOIUrl":"https://doi.org/10.37174/2587-7593-2024-7-2-46-54","url":null,"abstract":"Purpose: To clarify the possibility of metastatic lesions of intrapulmonary lymph nodes in patients with malignant neoplasms of extrapulmonary localization by analyzing retrospective and prospective material.Material and methods: Our study included 139 patients. The criterion for selecting patients was a morphologically confirmed on­cological diagnosis and the presence of lesions in the lungs. Patients were recruited from two large groups of leading localizations in the general structure of cancer incidence: a group of patients with colorectal cancer — 76 (54.7 %) and a group of patients with malignant breast tumors — 63 (45.3 %). A total of 312 lung lesions were identified and analyzed in 139 patients. High-resolution computed tomography with a slice thickness of up to 1-1.5 mm of the chest was performed in all patients. Assessment of dynamics in all patients was carried out for at least 3 years.Results: As a result, out of 139 patients with newly detected lesions in the lungs, 43 (30.9 %) patients had lesions identified, which we classified as intrapulmonary regional lymph nodes (RLNs). A total of 75 (24.0 %) lesions classified as typical or atypical RLNs were identified. We obtained the following data: RLNs were located predominantly in the lower lobes — 46.7 %, 84 % of RLNs were localized below the carina. A total of 37.3 % of lesions were classified as perifissural lesions, 62.7 % of identified lesions were classified as subpleural (peripleural) lesions. It was found that the RLNs were localized on the pleura or had a connection with it through a thin septum — 49.3 % and 38.7 %, respectively. The average diameter of the RLN in the lung was 4.0 mm. RLNs were triangular in shape in 64 %, round (lenticular) in 21.3 %, and oval in 14.7 % of cases. 96 % of the lesions we classified as RLN were monitored over time using HRCT for 3 years or more, 4 % of the lesions underwent surgical treatment. All the lesions that we observed over the course of 3 years remained without dynamics. Based on the data obtained, we concluded that RLNs in patients with solid tumors of extrapulmonary locations and lesions in the lungs are benign changes and do not require dynamic monitoring.Conclusions: Lesions in patients with solid tumors of extrapulmonary localization classified as RLN are benign changes and do not affect the stage and nature of the treatment, and also do not require dynamic monitoring.","PeriodicalId":502542,"journal":{"name":"Journal of oncology: diagnostic radiology and radiotherapy","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiosurgical Maintenance of Indeterminate Proximal Biliary Stricture. Clinical Observation 放射外科手术维持不确定的近端胆道狭窄。临床观察
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-86-97
S. M. Abdulkarimova, O. N. Sergeeva, I.  . Pogrebnyakov, E. R. Virschke, E. A. Nasonova, D. Frantsev, E. V. Uryumova, M. G. Lapteva, E. Moroz, O. V. Chistyakova, B. Dolgushin
The paper presents a case of an indeterminate proximal biliary stricture in a patient who admitted to the N.N. Blokhin National Medical Research Center of Oncology with a referral diagnosis of Klatskin tumor and 6 years earlier had undergone cholecystectomy for calculous cholecystitis complicated by Mirizzi syndrome. The authors highlight the difficulties of biliary lesion differentiation as well as the importance of anamnestic, clinical, imaging, laboratory and morphological data synthesis with the emphasis on percucationous endobiliary interventions to establish the etiology of the disease.
本文介绍了一例胆道近端狭窄的不确定病例,该患者因克拉茨基肿瘤转诊至N.N. Blokhin国立肿瘤医学研究中心,6年前曾因结石性胆囊炎并发米利兹综合征接受胆囊切除术。作者强调了胆道病变鉴别的困难,以及综合肛诊、临床、影像学、实验室和形态学数据的重要性,并强调了泌尿系内胆道介入治疗对确定病因的重要性。
{"title":"Radiosurgical Maintenance of Indeterminate Proximal Biliary Stricture. Clinical Observation","authors":"S. M. Abdulkarimova, O. N. Sergeeva, I.  . Pogrebnyakov, E. R. Virschke, E. A. Nasonova, D. Frantsev, E. V. Uryumova, M. G. Lapteva, E. Moroz, O. V. Chistyakova, B. Dolgushin","doi":"10.37174/2587-7593-2024-7-2-86-97","DOIUrl":"https://doi.org/10.37174/2587-7593-2024-7-2-86-97","url":null,"abstract":"The paper presents a case of an indeterminate proximal biliary stricture in a patient who admitted to the N.N. Blokhin National Medical Research Center of Oncology with a referral diagnosis of Klatskin tumor and 6 years earlier had undergone cholecystectomy for calculous cholecystitis complicated by Mirizzi syndrome. The authors highlight the difficulties of biliary lesion differentiation as well as the importance of anamnestic, clinical, imaging, laboratory and morphological data synthesis with the emphasis on percucationous endobiliary interventions to establish the etiology of the disease.","PeriodicalId":502542,"journal":{"name":"Journal of oncology: diagnostic radiology and radiotherapy","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PET/CT with 68Ga-DOTA-TATE and 68Ga-FAPI in the Diagnosis of Neuroendocrine Tumors. Clinical Cases 使用 68Ga-DOTA-TATE 和 68Ga-FAPI 的 PET/CT 诊断神经内分泌肿瘤。临床病例
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-9-14
E. V. Belkin, P. E. Tulin, A. Odzharova
Purpose: To perform a comparative analysis of diagnostic efficiency of PET/CT with 68Ga-DOTA-TATE and 68Ga-FAPI on the example of clinical cases of NEO (detection of primary tumor and extra-organ metastases).Material and methods: Two patients with pancreatic NEO underwent PET/CT studies with 68Ga-DOTA-TATE and 68Ga-FAPI before treatment. PET/CT with 68Ga-DOTA-TATE successfully visualized primary tumors in both patients; evidence of a metastatic process in the liver was obtained in one patient. PET/CT with 68Ga-FAPI showed non-optimal visualization of primary tumors, no liver metastases were detected.Conclusion: PET/CT with 68Ga-DOTA-TATE is a more effective method of radionuclide diagnostics of NEO than PET/CT with 68Ga-FAPI.
目的:以胰腺癌近端转移(NEO)临床病例为例,比较分析68Ga-DOTA-TATE和68Ga-FAPI PET/CT的诊断效率(检测原发肿瘤和器官外转移):材料: 两名胰腺NEO患者在治疗前接受了68Ga-DOTA-TATE和68Ga-FAPI的PET/CT检查。68Ga-DOTA-TATE正电子发射计算机断层显像/计算机断层成像成功地显示了两名患者的原发性肿瘤;一名患者获得了肝脏转移过程的证据。使用68Ga-FAPI的PET/CT显示原发肿瘤的显像效果不佳,但未发现肝转移:结论:与 68Ga-FAPI PET/CT 相比,68Ga-DOTA-TATE PET/CT 是一种更有效的近地天体放射性核素诊断方法。
{"title":"PET/CT with 68Ga-DOTA-TATE and 68Ga-FAPI in the Diagnosis of Neuroendocrine Tumors. Clinical Cases","authors":"E. V. Belkin, P. E. Tulin, A. Odzharova","doi":"10.37174/2587-7593-2024-7-2-9-14","DOIUrl":"https://doi.org/10.37174/2587-7593-2024-7-2-9-14","url":null,"abstract":"Purpose: To perform a comparative analysis of diagnostic efficiency of PET/CT with 68Ga-DOTA-TATE and 68Ga-FAPI on the example of clinical cases of NEO (detection of primary tumor and extra-organ metastases).Material and methods: Two patients with pancreatic NEO underwent PET/CT studies with 68Ga-DOTA-TATE and 68Ga-FAPI before treatment. PET/CT with 68Ga-DOTA-TATE successfully visualized primary tumors in both patients; evidence of a metastatic process in the liver was obtained in one patient. PET/CT with 68Ga-FAPI showed non-optimal visualization of primary tumors, no liver metastases were detected.Conclusion: PET/CT with 68Ga-DOTA-TATE is a more effective method of radionuclide diagnostics of NEO than PET/CT with 68Ga-FAPI.","PeriodicalId":502542,"journal":{"name":"Journal of oncology: diagnostic radiology and radiotherapy","volume":" 88","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of PET/CT Description with 18F-Fluoroestradiol in Patients with Estrogen-Positive Breast Cancer 使用 18F- 氟雌二醇对雌激素阳性乳腺癌患者进行 PET/CT 分析的特点
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-27-36
A. V. Parnas, A. Pronin, D. Ryabchikov, P. E. Tulin, A. Subbotin, V. S. Ilyakov, N. V. Cherepanova, Yu. I. Prokofiev
Purpose: To study possible errors in the interpretation and analysis of PET/CT studies with 18F-FES performed in patients with estrogen receptor-positive breast tumors.Material and methods: Data PET/CT with 18F-FES from 140 PET patients were retrospectively analyzed from 2017 to 2023. The study included patients with histologically confirmed estrogen receptor-positive breast cancer, before the start of specific treat­ment, as well as when progression is detected or if a metastatic process is suspected at the initial examination stage.Results: Recommendations are given for the assessment and interpretation of various changes detected during PET/CT with 18F-FES in patients with estrogen receptor-positive breast cancer, which may cause difficulties in analyzing the results of the study.Conclusion: Although the PET/CT with 18F-FES in our country has not yet been widely introduced into clinical practice, in some institutions the study is carried out within the framework of scientific protocols and in complex cases of differential diagnosis. For a more correct interpretation of PET/CT with 18F-FES should take into account the clinical and morphological features in each clinical case.
目的:研究对雌激素受体阳性乳腺肿瘤患者进行的18F-FES PET/CT研究的解释和分析中可能存在的错误:回顾性分析了2017年至2023年期间140例PET患者的18F-FES PET/CT数据。研究对象包括组织学确诊的雌激素受体阳性乳腺癌患者,在开始接受特定治疗之前,以及在初始检查阶段发现病情进展或怀疑有转移过程时:结果:对雌激素受体阳性乳腺癌患者进行 18F-FES PET/CT 检查时发现的各种变化的评估和解释提出了建议,这些变化可能会给研究结果的分析带来困难:虽然在我国,18F-FES PET/CT 还未广泛应用于临床实践,但在一些机构中,这项研究是在科学方案的框架内进行的,而且是在鉴别诊断的复杂病例中进行的。为了更正确地解读18F-FES正电子发射计算机断层显像,应考虑到每个临床病例的临床和形态特征。
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引用次数: 0
Method for Assessing Local Metabolism of Mammary Tumors Based on Multimodal Optical Technology 基于多模态光学技术的乳腺肿瘤局部代谢评估方法
Pub Date : 2024-07-04 DOI: 10.37174/2587-7593-2024-7-2-37-45
M. Arabachyan, V. Shupletsov, M. Kirillin, A. Dunaev, E. V. Potapova
Introduction. Breast cancer (BC) is the most common malignant tumor in women worldwide. It amounts more than 16 % of all cases of malignant neoplasms in women. Modern advances in radiological methods of breast tumors detection significantly increased the number of non-palpable neoplasms revealed during examinations, while further progress requires the development of improved minimally invasive techniques for obtaining biopsy material from breast tumors using tools of navigational controls. An approach with high potential for direct evaluation of local tumor metabolism consists in complementary use of fluorescence spectroscopy and diffuse reflectance spectroscopy.Purpose: Evaluation of the effectiveness of a new complementary approach for the diagnosis of the metabolic status of breast tumors in patients suspicious for breast cancer.Material and methods. This article presents the results of the examination of 21 patients with breast neoplasms who, in addition to standard examination methods, including ultrasound, X-ray mammography, puncture biopsy and trepanobiopsy, were subject to evaluation of local tumor metabolism with complementary employment of fluorescence spectroscopy and diffuse reflectance spectroscopy .Results. It has been established that the malignant breast tumors have lower saturation values compared with both benign tumors and the surrounding healthy tissue: StO2(BC) = 6,6 % [5,7-24,8 %]; 79,0 % [77,6-84,4 %], StO2(fibroadenoma) = 66,3 %[43,7-74,8 %]. It is also found that the malignant tumors have higher values of NADPH compared with the benign tumors (INAD(P) H(BC) = 6157 a.u. [2188-8814 a.u.]; INADH (fibroadenoma) = 2962 a.u. [1924-4301 a.u. ]).Conclusion. The new method of the diagnosis of the local breast tumor metabolism can be further used to improve the results of targeted biopsies under ultrasound control and to assess the therapeutic pathomorphosis of BC. To evaluate the effectiveness of this diagnostic method, it is necessary to continue the study with a larger number of patients in order to obtain statistically reliable data.
导言乳腺癌(BC)是全球妇女最常见的恶性肿瘤。它占所有女性恶性肿瘤病例的 16%以上。现代乳腺肿瘤放射学检测方法的进步大大增加了在检查中发现的非扪及肿瘤的数量,而进一步的进步需要开发更好的微创技术,利用导航控制工具从乳腺肿瘤中获取活检材料。目的:评估一种新的互补方法对诊断乳腺癌可疑患者乳腺肿瘤代谢状况的有效性。本文介绍了对 21 名乳腺肿瘤患者的检查结果,这些患者除了接受超声波、X 射线乳腺摄影、穿刺活检和穿刺活检等标准检查方法外,还接受了荧光光谱法和漫反射光谱法的补充应用,以评估局部肿瘤的代谢情况。与良性肿瘤和周围健康组织相比,恶性乳腺肿瘤的饱和度值较低:StO2(乳腺癌)= 6.6 % [5.7-24.8 %];79.0 % [77.6-84.4 %],StO2(纤维腺瘤)= 66.3 % [43.7-74.8 %]。研究还发现,与良性肿瘤相比,恶性肿瘤的 NADPH 值更高(INAD(P) H(BC) = 6157 a.u. [2188-8814 a.u.]; INADH(纤维腺瘤)= 2962 a.u. [1924-4301 a.u.])。新的乳腺肿瘤局部代谢诊断方法可进一步用于改善超声控制下靶向活检的结果,以及评估 BC 的治疗病理形态。为了评估这种诊断方法的有效性,有必要继续对更多的患者进行研究,以获得统计上可靠的数据。
{"title":"Method for Assessing Local Metabolism of Mammary Tumors Based on Multimodal Optical Technology","authors":"M. Arabachyan, V. Shupletsov, M. Kirillin, A. Dunaev, E. V. Potapova","doi":"10.37174/2587-7593-2024-7-2-37-45","DOIUrl":"https://doi.org/10.37174/2587-7593-2024-7-2-37-45","url":null,"abstract":"Introduction. Breast cancer (BC) is the most common malignant tumor in women worldwide. It amounts more than 16 % of all cases of malignant neoplasms in women. Modern advances in radiological methods of breast tumors detection significantly increased the number of non-palpable neoplasms revealed during examinations, while further progress requires the development of improved minimally invasive techniques for obtaining biopsy material from breast tumors using tools of navigational controls. An approach with high potential for direct evaluation of local tumor metabolism consists in complementary use of fluorescence spectroscopy and diffuse reflectance spectroscopy.Purpose: Evaluation of the effectiveness of a new complementary approach for the diagnosis of the metabolic status of breast tumors in patients suspicious for breast cancer.Material and methods. This article presents the results of the examination of 21 patients with breast neoplasms who, in addition to standard examination methods, including ultrasound, X-ray mammography, puncture biopsy and trepanobiopsy, were subject to evaluation of local tumor metabolism with complementary employment of fluorescence spectroscopy and diffuse reflectance spectroscopy .Results. It has been established that the malignant breast tumors have lower saturation values compared with both benign tumors and the surrounding healthy tissue: StO2(BC) = 6,6 % [5,7-24,8 %]; 79,0 % [77,6-84,4 %], StO2(fibroadenoma) = 66,3 %[43,7-74,8 %]. It is also found that the malignant tumors have higher values of NADPH compared with the benign tumors (INAD(P) H(BC) = 6157 a.u. [2188-8814 a.u.]; INADH (fibroadenoma) = 2962 a.u. [1924-4301 a.u. ]).Conclusion. The new method of the diagnosis of the local breast tumor metabolism can be further used to improve the results of targeted biopsies under ultrasound control and to assess the therapeutic pathomorphosis of BC. To evaluate the effectiveness of this diagnostic method, it is necessary to continue the study with a larger number of patients in order to obtain statistically reliable data.","PeriodicalId":502542,"journal":{"name":"Journal of oncology: diagnostic radiology and radiotherapy","volume":" 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of oncology: diagnostic radiology and radiotherapy
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