Sepsis and septic shock associated with tuberculosis “Landouzy's tifobacilosis”: A dark and unpredictable enemy – From pathophysiology to clinical implications

Acta Colombiana de Cuidado Intensivo Pub Date : 2025-01-01 DOI:10.1016/j.acci.2024.06.002

Jose Dario Portillo-Miño , José Leonel Zambrano-Urbano , Diego Fernando Taramuel-Gómez , Franco Andrés Montenegro-Coral , Nasly Violedy Ipia Ordoñez , Luis Guillermo Andino-Bucheli , Leopoldo Javier Eraso-García , Hector Fabio Sanchez-Galvez , Jorge Ignacio Martínez-Díaz

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Abstract

Sepsis and septic shock associated with tuberculosis are such critical diseases that are life-threatening to the patient. TB bacteremia has been associated with sepsis and septic shock, especially in immunosuppressed patients with high mortality. In this sense, it has been seen that 1 in 4 patients infected with human immunodeficiency virus (HIV) hospitalized for sepsis had TB bacteremia. Acute forms of tuberculosis can progress in severity and between 1 and 3% of cases require an Intensive Care Unit (ICU) and high mortality. Given this scenario, the authors consider it pertinent to carry out this Review article, which allows a diagnostic and therapeutic approach to this acute form of TB to provide key aspects of the disease that are decisive in saving the lives of patients in critical condition.

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