Self-assembled amphiphilic peptide hydrogels for antimicrobial application

IF 7.9 2区 化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Colloid & Interface Science Pub Date : 2024-07-04 DOI:10.1016/j.cocis.2024.101828
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Abstract

Due to the widespread and excessive use of antibiotics, bacterial resistance has become an increasingly serious problem affecting public health. Amphiphilic peptide hydrogels have good biological and mechanical properties, and can be used as ideal substitutes for antibiotics in the fields of infection control and wound healing. This review systematically summarized the design principles, assembly mechanism, and the latest progress of amphiphilic peptide hydrogels. Based on the molecular structure and function of peptides, the antibacterial mechanism of amphiphilic peptide hydrogels is further elaborated. Finally, we provide a perspective for the future development of antibacterial applications of amphiphilic peptide hydrogels. It is hoped that this review can provide inspiration for the design of amphiphilic peptide hydrogels and promote their clinical transformation against bacterial infections.

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用于抗菌的自组装两亲肽水凝胶
由于抗生素的广泛和过度使用,细菌耐药性已成为影响公众健康的一个日益严重的问题。两亲肽水凝胶具有良好的生物学和机械性能,可作为抗生素的理想替代品应用于感染控制和伤口愈合领域。本综述系统总结了两亲肽水凝胶的设计原理、组装机理和最新进展。根据肽的分子结构和功能,进一步阐述了两亲肽水凝胶的抗菌机理。最后,我们对两亲肽水凝胶抗菌应用的未来发展进行了展望。希望这篇综述能为两亲肽水凝胶的设计提供启发,并促进其在临床上抗击细菌感染的转化。
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来源期刊
CiteScore
16.50
自引率
1.10%
发文量
74
审稿时长
11.3 weeks
期刊介绍: Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.
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