Bahareh Farasati Far , Mohammad Reza Naimi-Jamal , Sepideh Ahmadi , Navid Rabiee
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引用次数: 0
Abstract
Cancer treatment often requires a multimodal approach, such as combining chemotherapy and gene therapy. However, challenges such as low therapeutic efficacy and off-target effects hinder the effectiveness of these treatments. In this study, the use of calcium-doped metal-organic frameworks Cu2(BDC)2(DABCO) as a nanocarrier platform for the co-delivery of doxorubicin (DOX) and plasmid CRISPR (pCRISPR) proposed to enhance anticancer efficiency. We demonstrated that Ca-doped MOF nanocarriers significantly improved the uptake of DOX and pCRISPR by in cancer cells. The co-delivery of DOX and pCRISPR with Ca-doped MOF nanocarriers resulted in a significant rise in cell death and decreased targeted gene expression.
期刊介绍：
Nano Materials Science (NMS) is an international and interdisciplinary, open access, scholarly journal. NMS publishes peer-reviewed original articles and reviews on nanoscale material science and nanometer devices, with topics encompassing preparation and processing; high-throughput characterization; material performance evaluation and application of material characteristics such as the microstructure and properties of one-dimensional, two-dimensional, and three-dimensional nanostructured and nanofunctional materials; design, preparation, and processing techniques; and performance evaluation technology and nanometer device applications.
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