The ignored structure in female fertility: cilia in the fallopian tubes

IF 3.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY Reproductive biomedicine online Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI:10.1016/j.rbmo.2024.104346

Liuqing He , Haofei Xu , Min Liu , Ying Tan , Shiyu Huang , Xiaoxiao Yin , Xinyu Luo , Hui Yee Chung , Ming Gao , Yujie Li , Weijun Ding , Hang Zhou , Yefang Huang

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Abstract

Cilia in the fallopian tubes (CFT) play an important role in female infertility, but have not been explored comprehensively. This review reveals the detection techniques for CFT function and morphology, and the related analysis of female infertility and other gynaecological disorders. CFT differentiate from progenitor cells, and develop into primary cilia and motile cilia. Primary cilia coordinate multiple signalling pathways, and motile cilia produce laminar flow through bidirectional intraflagellar transport, which drives the movement of oocytes and gametes. Several methods for quantitative detection and protein analysis have been used to explore the factors contributing to the decrease in ciliary beat frequency (CBF), and the cellular mechanism of ciliary cell death and shedding. In both primary and secondary ciliary disorders associated with reproductive diseases, abnormal alterations in ciliary quantity, ciliary structure, CBF and ciliary signalling pathways result in abnormal tubal laminar flow, and diminished oocyte retrieval and transport capabilities.

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被忽视的女性生育结构：输卵管纤毛

输卵管纤毛（CFT）在女性不孕症中起重要作用，但尚未得到全面的探讨。本文综述了CFT功能和形态的检测技术，以及对女性不孕症和其他妇科疾病的相关分析。CFT由祖细胞分化为原代纤毛和活动纤毛。初级纤毛协调多种信号通路，活动纤毛通过鞭毛内双向运输产生层流，驱动卵母细胞和配子的运动。通过定量检测和蛋白分析等方法，探讨了导致纤毛搏动频率（CBF）降低的因素，以及纤毛细胞死亡和脱落的细胞机制。在与生殖疾病相关的原发性和继发性纤毛疾病中，纤毛数量、纤毛结构、CBF和纤毛信号通路的异常改变导致输卵管层流异常，卵母细胞回收和运输能力下降。

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来源期刊

Reproductive biomedicine online 医学-妇产科学

CiteScore

7.20

自引率

7.50%

发文量

391

审稿时长

50 days

期刊介绍： Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients. Context: The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.