A bidirectional framework for fracture simulation and deformation-based restoration prediction in pelvic fracture surgical planning

IF 10.7 1区 医学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Medical image analysis Pub Date : 2024-07-10 DOI:10.1016/j.media.2024.103267
Bolun Zeng , Huixiang Wang , Xingguang Tao , Haochen Shi , Leo Joskowicz , Xiaojun Chen
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Abstract

Pelvic fracture is a severe trauma with life-threatening implications. Surgical reduction is essential for restoring the anatomical structure and functional integrity of the pelvis, requiring accurate preoperative planning. However, the complexity of pelvic fractures and limited data availability necessitate labor-intensive manual corrections in a clinical setting. We describe in this paper a novel bidirectional framework for automatic pelvic fracture surgical planning based on fracture simulation and structure restoration. Our fracture simulation method accounts for patient-specific pelvic structures, bone density information, and the randomness of fractures, enabling the generation of various types of fracture cases from healthy pelvises. Based on these features and on adversarial learning, we develop a novel structure restoration network to predict the deformation mapping in CT images before and after a fracture for the precise structural reconstruction of any fracture. Furthermore, a self-supervised strategy based on pelvic anatomical symmetry priors is developed to optimize the details of the restored pelvic structure. Finally, the restored pelvis is used as a template to generate a surgical reduction plan in which the fragments are repositioned in an efficient jigsaw puzzle registration manner. Extensive experiments on simulated and clinical datasets, including scans with metal artifacts, show that our method achieves good accuracy and robustness: a mean SSIM of 90.7% for restorations, with translational errors of 2.88 mm and rotational errors of 3.18°for reductions in real datasets. Our method takes 52.9 s to complete the surgical planning in the phantom study, representing a significant acceleration compared to standard clinical workflows. Our method may facilitate effective surgical planning for pelvic fractures tailored to individual patients in clinical settings.

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骨盆骨折手术规划中的骨折模拟和基于变形的修复预测双向框架
骨盆骨折是一种严重创伤,会危及生命。手术复位对于恢复骨盆的解剖结构和功能完整性至关重要,需要准确的术前规划。然而,骨盆骨折的复杂性和有限的数据可用性使得在临床环境中必须进行劳动密集型的人工矫正。我们在本文中介绍了一种基于骨折模拟和结构复原的新型骨盆骨折自动手术规划双向框架。我们的骨折模拟方法考虑了患者特定的骨盆结构、骨密度信息和骨折的随机性,能够从健康的骨盆中生成各种类型的骨折病例。基于这些特征和对抗学习,我们开发了一种新型结构复原网络,用于预测骨折前后 CT 图像中的形变映射,从而精确重建任何骨折的结构。此外,我们还开发了一种基于骨盆解剖对称先验的自监督策略,以优化修复后骨盆结构的细节。最后,将修复后的骨盆作为模板,生成手术缩小计划,以高效的拼图注册方式重新定位骨折片。在模拟和临床数据集(包括带有金属伪影的扫描)上进行的大量实验表明,我们的方法具有良好的准确性和鲁棒性:修复的平均 SSIM 值为 90.7%,在真实数据集上进行缩减时,平移误差为 2.88 mm,旋转误差为 3.18°。在模型研究中,我们的方法只需 52.9 秒就能完成手术规划,与标准临床工作流程相比明显加快。我们的方法有助于在临床环境中为骨盆骨折患者量身定制有效的手术规划。
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来源期刊
Medical image analysis
Medical image analysis 工程技术-工程:生物医学
CiteScore
22.10
自引率
6.40%
发文量
309
审稿时长
6.6 months
期刊介绍: Medical Image Analysis serves as a platform for sharing new research findings in the realm of medical and biological image analysis, with a focus on applications of computer vision, virtual reality, and robotics to biomedical imaging challenges. The journal prioritizes the publication of high-quality, original papers contributing to the fundamental science of processing, analyzing, and utilizing medical and biological images. It welcomes approaches utilizing biomedical image datasets across all spatial scales, from molecular/cellular imaging to tissue/organ imaging.
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