1234 Optimising Vitamin D and Calcium Management in Thyroidectomy Patients

IF 5.5 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2024-07-01 DOI:10.1093/bjs/znae163.120
B. Yussuf, N. Tharakaran, M. Roderick, L. Thomas
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Abstract

The study aimed to investigate the causes of temporary postoperative hypocalcemia and strategies for correction. Objectives included assessing the impact of preoperative trust guidelines on detecting and managing Vitamin D deficiency in thyroidectomy patients and analyzing its correlation with postoperative hypocalcemia at Northampton General Hospital. A three-cycle audit analyzed 16, 12, and 8 cases, respectively, encompassing total and completion thyroidectomies at NGH. Collaborative development of standardized trust guidelines involved the ENT Team, Endocrinology, and Pharmacists. Data collection covered various parameters, and departmental teachings were conducted to educate the team on the new guidelines. Thyroidectomy indications included Graves's disease, large Multinodular Goitre, and malignancy. In the third cycle, all patients underwent preoperative Vitamin D checks, aligning postoperative hypocalcemia with the national range. Our interventions increased preoperative Vitamin D checks from 56% to 100%, reducing deficiency from 25% to 0%. Postoperative hypocalcemia decreased from 56% in Cycle 1 to 8.3% in Cycle 2 and 12.5% in Cycle 3. Long-term hypoparathyroidism dropped to 0% in Cycle 3, with no correlation between surgeon technique or indication and postoperative hypocalcemia. The introduction of preoperative guidelines significantly enhanced Vitamin D deficiency detection, substantially reducing postoperative hypocalcemia. This underscores the positive impact of standardized protocols on patient care. Future efforts involve re-auditing with the involvement of junior doctors to ensure continuous enhancement in clinical practice.
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1234 优化甲状腺切除术患者的维生素 D 和钙管理
该研究旨在调查术后暂时性低钙血症的原因和纠正策略。目标包括评估北安普顿综合医院术前信任指南对检测和管理甲状腺切除术患者维生素D缺乏症的影响,并分析其与术后低钙血症的相关性。 三周期审计分别分析了北安普顿综合医院的16例、12例和8例甲状腺全切术和甲状腺全切术病例。耳鼻喉科团队、内分泌科和药剂师参与了标准化信任指南的合作开发。数据收集涵盖了各种参数,并在科室内开展了有关新指南的培训。 甲状腺切除术的适应症包括巴塞杜氏病、巨大多结节性甲状腺肿和恶性肿瘤。在第三个周期,所有患者都接受了术前维生素D检查,使术后低钙血症符合国家规定的范围。我们的干预措施将术前维生素 D 检查率从 56% 提高到 100%,将缺乏率从 25% 降低到 0%。术后低钙血症从第一周期的56%降至第二周期的8.3%和第三周期的12.5%。第3周期的长期甲状旁腺功能减退症降至0%,外科医生的技术或适应症与术后低钙血症之间没有关联。 术前指南的引入大大提高了维生素D缺乏症的检测率,大大减少了术后低钙血症的发生。这强调了标准化方案对患者护理的积极影响。今后的工作包括在初级医生的参与下重新进行审核,以确保临床实践的持续改进。
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来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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