Revolutionizing of bioactive natural products in prostate cancer research and care: Promising discoveries and future directions

Konatham Teja Kumar Reddy , Karthickeyan Krishnan , Palani Shanmugasundaram , C. Ronald Darwin , Balaji Pandian , Saravanan Govindaraj , Priyanga Jaganath , Sridevi Ganesan
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Abstract

Globally, prostate cancer (PCa) is one of the most common cancers to strike men. Diet and lifestyle appear to have a significant impact on PCa biology and carcinogenesis. PCa is the major reason of death by cancer in men. Anti-PCa qualities like growth of tumor inhibition, induction of cell death, and angiogenesis and metastasis inhibition have all been studied in depth. Phytochemicals have been demonstrated to target androgen receptor (AR) signaling as well as PCa stem cells in a selection of investigations. Marine compounds have shown potential in the treatment of PCa. It is discussed in this article, some of the most promising bioactive natural and marine compounds for PCa prevention and treatment, as well as their specific methods of action. An emphasis on specific medicine is one of the future directions in the revolutionization of bioactive natural ingredients for PCa research and therapy. Advances in nanotechnology can enhance the bioavailability and specificity of bioactive substances for cancer cells, maximizing their therapeutic potential and enhancing patient treatment. Bioactive natural compounds represent an innovative field in the study and treatment of PCa. Promising results point to their potential to block cancer pathways and improve on already effective therapeutic approaches. As we advance, modified medicine, nanotechnology, and genomics methods will be fundamental in maximizing the efficacy of these natural substances and ultimately changing the treatment of PCa. But in order to close the gap between exciting findings and therapeutic application, more study, clinical trials, and effective activities are essential.
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生物活性天然产品在前列腺癌研究和治疗中的革命性应用:有希望的发现和未来方向
在全球范围内,前列腺癌(PCa)是男性最常见的癌症之一。饮食和生活方式似乎对 PCa 的生物学和癌变有重大影响。PCa 是男性死于癌症的主要原因。人们已经对抑制肿瘤生长、诱导细胞死亡、抑制血管生成和转移等抗 PCa 特性进行了深入研究。在一些研究中,植物化学物质已被证明能够靶向雄激素受体(AR)信号传导以及 PCa 干细胞。海洋化合物已显示出治疗 PCa 的潜力。本文将讨论一些最有希望用于预防和治疗 PCa 的生物活性天然化合物和海洋化合物,以及它们的具体作用方法。在 PCa 研究和治疗方面,强调特定药物是生物活性天然成分革命的未来方向之一。纳米技术的进步可以提高生物活性物质对癌细胞的生物利用度和特异性,最大限度地发挥其治疗潜力,加强对患者的治疗。生物活性天然成分是研究和治疗 PCa 的一个创新领域。令人鼓舞的研究结果表明,生物活性天然化合物具有阻断癌症通路和改进现有有效治疗方法的潜力。随着我们的进步,改良医学、纳米技术和基因组学方法将成为最大限度发挥这些天然物质疗效的基础,并最终改变 PCa 的治疗方法。但是,为了缩小令人兴奋的发现与治疗应用之间的差距,必须开展更多的研究、临床试验和有效的活动。
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