{"title":"Combinatorial therapies of surfactant-like antimicrobial peptides and antibiotics for improved therapeutic efficacy","authors":"","doi":"10.1016/j.cocis.2024.101829","DOIUrl":null,"url":null,"abstract":"<div><p>Multidrug combination therapies have been proven to be advantageous in combating the proliferation of antibiotic-resistant bacterial pathogens in recent years, not only contributing to the medical/therapeutic landscape but also offering insights into microbial ecology and evolution. Because antimicrobial surfactant-like peptides kill bacteria/fungi via disrupting the membranes, it is less likely for the microorganisms to develop resistance. Associations of two or more drugs with at least one of them to be an antimicrobial peptide have contributed to the treatment of difficult-to-treat infectious diseases caused by pathogens in numerous <em>in vitro</em> studies. The synergistic action of cationic antimicrobial peptide or surfactant-like molecule with a current antibiotic can bring an effective measure to overcome antimicrobial resistance. Through reviewing recent advances in combinatorial therapies, we show that synergy between different agent types could be a fundamental defense strategy to find against multidrug resistance. Peptide combinations and conjugations with themselves or other molecules could effectively avoid the disadvantages of individual compounds, enhancing antibacterial activity, delivery efficiency and selectivity whilst introducing new functionalities. Combined therapies among peptide amphiphiles, antibiotics and non-antibiotics may provide a practical avenue for an effective management of antibiotic-resistant superbugs and biofilms.</p></div>","PeriodicalId":293,"journal":{"name":"Current Opinion in Colloid & Interface Science","volume":null,"pages":null},"PeriodicalIF":7.9000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Colloid & Interface Science","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1359029424000475","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Multidrug combination therapies have been proven to be advantageous in combating the proliferation of antibiotic-resistant bacterial pathogens in recent years, not only contributing to the medical/therapeutic landscape but also offering insights into microbial ecology and evolution. Because antimicrobial surfactant-like peptides kill bacteria/fungi via disrupting the membranes, it is less likely for the microorganisms to develop resistance. Associations of two or more drugs with at least one of them to be an antimicrobial peptide have contributed to the treatment of difficult-to-treat infectious diseases caused by pathogens in numerous in vitro studies. The synergistic action of cationic antimicrobial peptide or surfactant-like molecule with a current antibiotic can bring an effective measure to overcome antimicrobial resistance. Through reviewing recent advances in combinatorial therapies, we show that synergy between different agent types could be a fundamental defense strategy to find against multidrug resistance. Peptide combinations and conjugations with themselves or other molecules could effectively avoid the disadvantages of individual compounds, enhancing antibacterial activity, delivery efficiency and selectivity whilst introducing new functionalities. Combined therapies among peptide amphiphiles, antibiotics and non-antibiotics may provide a practical avenue for an effective management of antibiotic-resistant superbugs and biofilms.
期刊介绍:
Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications.
Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments.
Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.