Combinatorial therapies of surfactant-like antimicrobial peptides and antibiotics for improved therapeutic efficacy

IF 7.9 2区 化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Colloid & Interface Science Pub Date : 2024-07-10 DOI:10.1016/j.cocis.2024.101829
Mingrui Liao , Chunxian Wu , Kangcheng Shen , Xuzhi Hu , Jian R. Lu
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Abstract

Multidrug combination therapies have been proven to be advantageous in combating the proliferation of antibiotic-resistant bacterial pathogens in recent years, not only contributing to the medical/therapeutic landscape but also offering insights into microbial ecology and evolution. Because antimicrobial surfactant-like peptides kill bacteria/fungi via disrupting the membranes, it is less likely for the microorganisms to develop resistance. Associations of two or more drugs with at least one of them to be an antimicrobial peptide have contributed to the treatment of difficult-to-treat infectious diseases caused by pathogens in numerous in vitro studies. The synergistic action of cationic antimicrobial peptide or surfactant-like molecule with a current antibiotic can bring an effective measure to overcome antimicrobial resistance. Through reviewing recent advances in combinatorial therapies, we show that synergy between different agent types could be a fundamental defense strategy to find against multidrug resistance. Peptide combinations and conjugations with themselves or other molecules could effectively avoid the disadvantages of individual compounds, enhancing antibacterial activity, delivery efficiency and selectivity whilst introducing new functionalities. Combined therapies among peptide amphiphiles, antibiotics and non-antibiotics may provide a practical avenue for an effective management of antibiotic-resistant superbugs and biofilms.

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表面活性剂类抗菌肽与抗生素的组合疗法,提高疗效
近年来,多药联合疗法已被证明在抗击抗生素耐药性细菌病原体的扩散方面具有优势,不仅为医疗/治疗领域做出了贡献,还为微生物生态学和进化提供了启示。由于抗菌剂表面活性剂样肽通过破坏薄膜杀死细菌/真菌,因此微生物不易产生抗药性。在大量体外研究中,两种或两种以上药物(其中至少有一种是抗菌肽)的联合作用有助于治疗由病原体引起的难以治疗的感染性疾病。阳离子抗菌肽或类表面活性剂分子与现有抗生素的协同作用,可为克服抗菌药耐药性带来有效措施。通过回顾组合疗法的最新进展,我们发现不同药剂类型之间的协同作用可能是对抗多重耐药性的基本防御策略。肽与自身或其他分子的组合和共轭可以有效避免单个化合物的缺点,提高抗菌活性、递送效率和选择性,同时引入新的功能。肽类双亲化合物、抗生素和非抗生素的联合疗法可为有效治疗抗生素耐药性超级细菌和生物膜提供切实可行的途径。
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来源期刊
CiteScore
16.50
自引率
1.10%
发文量
74
审稿时长
11.3 weeks
期刊介绍: Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.
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