{"title":"Synthesis and characterisation of PEG-coated CoFe2O4-based nanoparticles as anticancer nano-delivery systems","authors":"","doi":"10.1016/j.matlet.2024.137013","DOIUrl":null,"url":null,"abstract":"<div><p>As an anticancer nano drug carrier, the properties of nanoparticles for magnetic、drug loading and cytotoxic are significant. In this letter, three magnetic nanoparticles, CoFe<sub>2</sub>O<sub>4</sub>、γ-Fe<sub>2</sub>O<sub>3</sub>@CoFe<sub>2</sub>O<sub>4</sub>、CoFe<sub>2</sub>O<sub>4</sub>@MnFe<sub>2</sub>O<sub>4</sub> were synthesised, polyethylene glycol was used as a surface modifier for drug loading. The results show that γ-Fe<sub>2</sub>O<sub>3</sub>@CoFe<sub>2</sub>O<sub>4</sub>@PEG@DOX have better magnetic properties and drug-loading capacity and are more suitable for drug carriers. In addition, the cytotoxic effects on the 4 T1 cells of nanoparticles were determined by the CCK-8 test. Cell viability was lowest on γ-Fe<sub>2</sub>O<sub>3</sub>@CoFe<sub>2</sub>O<sub>4</sub>@PEG@DOX. All three nanocarriers are ultra-highly biocompatible and can be delivered to the nucleus after 6 h.</p></div>","PeriodicalId":384,"journal":{"name":"Materials Letters","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Letters","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167577X24011522","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
As an anticancer nano drug carrier, the properties of nanoparticles for magnetic、drug loading and cytotoxic are significant. In this letter, three magnetic nanoparticles, CoFe2O4、γ-Fe2O3@CoFe2O4、CoFe2O4@MnFe2O4 were synthesised, polyethylene glycol was used as a surface modifier for drug loading. The results show that γ-Fe2O3@CoFe2O4@PEG@DOX have better magnetic properties and drug-loading capacity and are more suitable for drug carriers. In addition, the cytotoxic effects on the 4 T1 cells of nanoparticles were determined by the CCK-8 test. Cell viability was lowest on γ-Fe2O3@CoFe2O4@PEG@DOX. All three nanocarriers are ultra-highly biocompatible and can be delivered to the nucleus after 6 h.
期刊介绍：
Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials.
Contributions include, but are not limited to, a variety of topics such as:
• Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors
• Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart
• Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction
• Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots.
• Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing.
• Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic
• Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive
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