{"title":"Association of plant-rich dietary patterns of mediterranean and MIND with risk of alzheimer disease","authors":"","doi":"10.1016/j.hnm.2024.200283","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>In recent decades, the possible synergistic power of nutrients in the form of dietary patterns has received attention in preventing diseases. This study aimed to investigate the association between plant-rich Mediterranean (MeDi) and MIND [MeDi-DASH (Dietary Approaches to Stop Hypertension) Intervention for Neurodegenerative Delay] dietary patterns with the risk of Alzheimer's disease (AD).</p></div><div><h3>Methods</h3><p>Sixty patients with AD and 29 healthy individuals were recruited. The cognitive functioning of the patients was measured using the Mini-Mental State Examination (MMSE) test. Participants’ food intake was evaluated using the three nonconsecutive days 24-h food recall method, and then MeDi and MIND dietary scores were calculated.</p></div><div><h3>Results</h3><p>Patients with AD had lower MIND diet scores than healthy subjects (p = 0.06), but the MeDi score did not significantly differ between the two groups. MIND and MeDi scores did not significantly differ between males and females. Each unit increase in MIND diet score was significantly correlated with a 40 % reduced risk of AD, and each unit increase in MeDi score was non-significantly correlated with a 14 % reduced risk of AD. Scores of MIND and MeDi patterns did not remarkably correlate with MMSE total score and cognitive domains.</p></div><div><h3>Conclusion</h3><p>The findings of this study suggest the promising affirmative effects of the MIND diet on reducing the risk of AD, but the protective effect of the MeDi pattern against the AD risk remains inconclusive.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666149724000458/pdfft?md5=92c5a7d90d01adfb68bf282b1a8d4bbd&pid=1-s2.0-S2666149724000458-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Nutrition and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666149724000458","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
In recent decades, the possible synergistic power of nutrients in the form of dietary patterns has received attention in preventing diseases. This study aimed to investigate the association between plant-rich Mediterranean (MeDi) and MIND [MeDi-DASH (Dietary Approaches to Stop Hypertension) Intervention for Neurodegenerative Delay] dietary patterns with the risk of Alzheimer's disease (AD).
Methods
Sixty patients with AD and 29 healthy individuals were recruited. The cognitive functioning of the patients was measured using the Mini-Mental State Examination (MMSE) test. Participants’ food intake was evaluated using the three nonconsecutive days 24-h food recall method, and then MeDi and MIND dietary scores were calculated.
Results
Patients with AD had lower MIND diet scores than healthy subjects (p = 0.06), but the MeDi score did not significantly differ between the two groups. MIND and MeDi scores did not significantly differ between males and females. Each unit increase in MIND diet score was significantly correlated with a 40 % reduced risk of AD, and each unit increase in MeDi score was non-significantly correlated with a 14 % reduced risk of AD. Scores of MIND and MeDi patterns did not remarkably correlate with MMSE total score and cognitive domains.
Conclusion
The findings of this study suggest the promising affirmative effects of the MIND diet on reducing the risk of AD, but the protective effect of the MeDi pattern against the AD risk remains inconclusive.
目的 近几十年来,营养素以膳食模式的形式在预防疾病方面可能产生的协同作用受到了关注。本研究旨在调查富含植物的地中海(MeDi)和 MIND [MeDi-DASH(膳食疗法抑制高血压)干预神经退行性延迟]膳食模式与阿尔茨海默病(AD)风险之间的关联。采用迷你精神状态检查(MMSE)测试测量患者的认知功能。结果AD患者的MIND饮食得分低于健康人(P = 0.06),但MeDi得分在两组间无显著差异。男性和女性的 MIND 和 MeDi 分数没有明显差异。MIND饮食得分每增加一个单位,患AD的风险就会降低40%,而MeDi得分每增加一个单位,患AD的风险就会降低14%。结论:本研究结果表明,MIND饮食对降低AD风险有积极作用,但MeDi饮食对AD风险的保护作用仍不确定。