Sleep-related disorders in patients with precapillary pulmonary hypertension

IF 11.2 1区 医学 Q1 CLINICAL NEUROLOGY Sleep Medicine Reviews Pub Date : 2024-07-03 DOI:10.1016/j.smrv.2024.101972
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Abstract

Precapillary pulmonary hypertension (PcPH) is associated with the development of sleep-related disorders and impairment of sleep quality. With growing recognition of the clinical relevance of sleep-related conditions in PcPH, this narrative review seeks to discuss the spectrum of disorders encountered in clinical practice, pathophysiological mechanisms linking PcPH with sleep-related disorders, and potential therapeutic considerations. Current evidence demonstrates a higher prevalence of impaired sleep quality, sleep-disordered breathing, sleep-related hypoxia, and restless leg syndrome in patients with PcPH. These sleep-related disorders could further lead to impairment of quality of life in a patient population with already a high symptom burden. Recent data suggest that sleep-related hypoxia is strongly linked to worse right ventricular function and higher risk of transplantation or death. However, limited studies have investigated the role of oxygen therapy or positive airway pressure therapy improving symptoms or outcomes. Abnormal iron homeostasis is highly prevalent in PcPH and may contribute to the development of restless legs syndrome/periodic limb movement of sleep. To improve sleep management in PcPH, we highlight future research agenda and advocate close collaboration between pulmonary hypertension specialists and sleep physicians.

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毛细血管前肺动脉高压患者的睡眠相关障碍
毛细血管前肺动脉高压(PcPH)与睡眠相关疾病的发生和睡眠质量的损害有关。随着人们越来越认识到前毛细血管性肺动脉高压与睡眠相关疾病的临床相关性,本综述旨在讨论临床实践中遇到的各种疾病、前毛细血管性肺动脉高压与睡眠相关疾病的病理生理机制以及潜在的治疗考虑因素。目前的证据表明,PcPH 患者中睡眠质量受损、睡眠呼吸紊乱、睡眠相关性缺氧和不宁腿综合征的发病率较高。这些与睡眠相关的疾病可能会进一步导致症状负担已经很重的患者生活质量下降。最近的数据表明,与睡眠相关的缺氧与右心室功能恶化、移植或死亡风险升高密切相关。然而,对氧疗或气道正压疗法在改善症状或预后方面作用的研究十分有限。铁稳态异常在 PcPH 中非常普遍,可能会导致不宁腿综合征/睡眠周期性肢体运动的发生。为了改善 PcPH 患者的睡眠管理,我们强调了未来的研究议程,并提倡肺动脉高压专科医生和睡眠医生密切合作。
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来源期刊
Sleep Medicine Reviews
Sleep Medicine Reviews 医学-临床神经学
CiteScore
20.10
自引率
3.80%
发文量
107
期刊介绍: Sleep Medicine Reviews offers global coverage of sleep disorders, exploring their origins, diagnosis, treatment, and implications for related conditions at both individual and public health levels. Articles comprehensively review clinical information from peer-reviewed journals across various disciplines in sleep medicine, encompassing pulmonology, psychiatry, psychology, physiology, otolaryngology, pediatrics, geriatrics, cardiology, dentistry, nursing, neurology, and general medicine. The journal features narrative reviews, systematic reviews, and editorials addressing areas of controversy, debate, and future research within the field.
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