What’s driving rhythmic gene expression: Sleep or the clock?

IF 9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Systems Pub Date : 2024-07-17 DOI:10.1016/j.cels.2024.06.006

引用次数: 0

Abstract

Rhythmic gene expression can originate not only from the autonomous rhythm of clock genes but likely also from sleep-wake cycles. Jan and colleagues used a novel model-based approach to dissect these individual effects and found that both factors contribute to gene expression rhythms, varying in degree within and across tissues.

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是什么在驱动有节奏的基因表达？睡眠还是时钟？

有节律的基因表达不仅源于时钟基因的自主节律，也可能源于睡眠-觉醒周期。杨及其同事使用了一种基于模型的新方法来剖析这些个体效应，发现这两种因素都有助于基因表达节律，而且在组织内部和组织之间的程度各不相同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Systems Medicine-Pathology and Forensic Medicine

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

42 days

期刊介绍： In 2015, Cell Systems was founded as a platform within Cell Press to showcase innovative research in systems biology. Our primary goal is to investigate complex biological phenomena that cannot be simply explained by basic mathematical principles. While the physical sciences have long successfully tackled such challenges, we have discovered that our most impactful publications often employ quantitative, inference-based methodologies borrowed from the fields of physics, engineering, mathematics, and computer science. We are committed to providing a home for elegant research that addresses fundamental questions in systems biology.