{"title":"Carphology","authors":"A Fo Ben","doi":"10.1136/pn-2024-004291","DOIUrl":null,"url":null,"abstract":"As if the poor lab mouse hasn’t had it hard enough, these stoic cheese stealers are now encouraged to develop murine long-COVID. Brain fog is a common symptom and interleukin-1, critical in the innate defence against the pandemic virus, is elevated in the hippocampi of people who’ve had COVID. Researchers set out to investigate the impact of vaccination on this process. They confirm that SARS-CoV-2 but not H1N1 flu induces the indicative rise of interleukin-1beta and a persistent interleukin driven loss of hippocampal neurogenesis, which was ameliorated when the mice were vaccinated against COVID. Nat Immunol . 2024 doi:10.1038/s41590-024-01868-z. Neurological pragmatists keen to super-charge the placebo value …","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":"74 1","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PRACTICAL NEUROLOGY","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/pn-2024-004291","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
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Abstract
As if the poor lab mouse hasn’t had it hard enough, these stoic cheese stealers are now encouraged to develop murine long-COVID. Brain fog is a common symptom and interleukin-1, critical in the innate defence against the pandemic virus, is elevated in the hippocampi of people who’ve had COVID. Researchers set out to investigate the impact of vaccination on this process. They confirm that SARS-CoV-2 but not H1N1 flu induces the indicative rise of interleukin-1beta and a persistent interleukin driven loss of hippocampal neurogenesis, which was ameliorated when the mice were vaccinated against COVID. Nat Immunol . 2024 doi:10.1038/s41590-024-01868-z. Neurological pragmatists keen to super-charge the placebo value …
期刊介绍：
The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.
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