Saliva Versus Plasma Therapeutic Drug Monitoring of Valproic Acid in Jordanian Patients.

IF 1.7 Q3 PHARMACOLOGY & PHARMACY Drug Research Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI:10.1055/a-2357-8095
Nasir Idkaidek, Aya Al-Tarawneh, Laith Alshoaibi, Haya Tuffaha, Asma Zinati, Majed Abdelqader, Ahmad Al-Ghazawi, Ayman Rabayah, Salim Hamadi
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Abstract

Therapeutic drug monitoring is used to ensure that medications are prescribed and administered according to safe doseage advice and for the purpose of achieving the desired therapeutic effects in patients. Several methods are used to perform therapeutic drug monitoring. However, there is insufficient evidence to currently support therapeutic drug monitoring of Valproic acid using salivary samples. The aim of this paper is to determine the feasibility of using salivary samples as a substitute for plasma samples for therapeutic drug monitoring of Valproic acid. In this study a total of 23 patients participated, with the mean age of 33.39. Salivary and plasma samples were collected and analysed to determine the peak and trough concentrations of Valproic acid for comparison between the two methods. Calibrated LC- MS/ MS was used to measure Valproic acid levels. Statistical analyses were performed using ANOVA test and ethical approval was obtained prior to sample collection. The results showed that saliva Valproic acid levels were less than that of plasma levels. There was no significant correlation between saliva and plasma level of Valproic acid (P>0.05). However, there was a significant correlation between the area under the curve for both saliva and plasma Valproic acid (P<0.05). Creatinine clearance was significantly correlated with peak plasma levels of Valproic acid (P<0.05). Albumin was significantly correlated with plasma levels of Valproic acid. There was also a significantly positive and moderate relationship between Log Saliva Cmax and Log plasma free Valproic acid concentration (r=0.76, p<0.018). In conclusion, saliva samples can be used as a substitute for plasma samples in the therapeutic drug monitoring of Valproic acid.

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约旦患者唾液与血浆中丙戊酸的治疗药物监测
治疗药物监测用于确保药物处方和用药符合安全剂量建议,并达到患者预期的治疗效果。治疗药物监测有多种方法。然而,目前还没有足够的证据支持使用唾液样本对丙戊酸进行治疗药物监测。本文旨在确定使用唾液样本替代血浆样本进行丙戊酸治疗药物监测的可行性。本研究共有 23 名患者参与,平均年龄为 33.39 岁。收集唾液和血浆样本并进行分析,以确定丙戊酸的峰值和谷值浓度,从而对两种方法进行比较。校准的 LC- MS/ MS 用于测量丙戊酸水平。统计分析采用方差分析,样本采集前已获得伦理批准。结果显示,唾液中的丙戊酸水平低于血浆中的丙戊酸水平。唾液中的丙戊酸水平与血浆中的丙戊酸水平无明显相关性(P>0.05)。但是,唾液和血浆中丙戊酸的曲线下面积有明显的相关性(P<0.05)。
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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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