Rayssa C Briânis, Fabrício A Moreira, Lia P Iglesias
{"title":"Cannabidiol and addiction.","authors":"Rayssa C Briânis, Fabrício A Moreira, Lia P Iglesias","doi":"10.1016/bs.irn.2024.03.006","DOIUrl":null,"url":null,"abstract":"<p><p>Cannabidiol (CBD) has been investigated for several therapeutic applications, having reached the clinics for the treatment of certain types of epilepsies. This chapter reviews the potential of CBD for the treatment of substance use disorders (SUD). We will present a brief introduction on SUD and current treatments. In the second part, preclinical and clinical studies with CBD are discussed, focusing on its potential therapeutic application for SUD. Next, we will consider the potential molecular mechanism of action of CBD in SUD. Finally, we will summarize the main findings and perspectives in this field. There is a lack of studies on CBD and SUD in comparison to the extensive literature investigating the use of this phytocannabinoid for other neurological and psychiatric disorders, such as epilepsy. However, the few studies available do suggest a promising role of CBD in the pharmacotherapy of SUD, particularly related to cocaine and other psychostimulant drugs.</p>","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"177 ","pages":"319-333"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International review of neurobiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/bs.irn.2024.03.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/3 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Cannabidiol (CBD) has been investigated for several therapeutic applications, having reached the clinics for the treatment of certain types of epilepsies. This chapter reviews the potential of CBD for the treatment of substance use disorders (SUD). We will present a brief introduction on SUD and current treatments. In the second part, preclinical and clinical studies with CBD are discussed, focusing on its potential therapeutic application for SUD. Next, we will consider the potential molecular mechanism of action of CBD in SUD. Finally, we will summarize the main findings and perspectives in this field. There is a lack of studies on CBD and SUD in comparison to the extensive literature investigating the use of this phytocannabinoid for other neurological and psychiatric disorders, such as epilepsy. However, the few studies available do suggest a promising role of CBD in the pharmacotherapy of SUD, particularly related to cocaine and other psychostimulant drugs.
人们已经对大麻二酚(CBD)的几种治疗用途进行了研究,并已将其用于治疗某些类型的癫痫。本章回顾了大麻二酚治疗药物使用障碍(SUD)的潜力。我们将简要介绍药物滥用障碍和当前的治疗方法。第二部分将讨论 CBD 的临床前研究和临床研究,重点关注其治疗 SUD 的潜力。接下来,我们将探讨 CBD 在 SUD 中的潜在分子作用机制。最后,我们将总结该领域的主要发现和展望。与研究这种植物大麻素用于其他神经和精神疾病(如癫痫)的大量文献相比,有关 CBD 和 SUD 的研究还很缺乏。不过,为数不多的研究确实表明,CBD 在药物治疗药物依赖性精神障碍(尤其是与可卡因和其他精神兴奋剂相关的药物)方面具有广阔的前景。