Update of gut gas metabolism in ulcerative colitis.

IF 3.8 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Expert Review of Gastroenterology & Hepatology Pub Date : 2024-07-01 Epub Date: 2024-07-24 DOI:10.1080/17474124.2024.2383635

Xiaohan Zhang, Xiuli Zhang, Yunsheng Yang

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Abstract

Introduction: Ulcerative colitis (UC) is a chronic, nonspecific inflammatory disease of the intestine. The intestinal microbiota is essential in the occurrence and development of UC. Gut gases are produced via bacterial fermentation or chemical interactions, which can reveal altered intestinal microbiota, abnormal cellular metabolism, and inflammation responses. Recent studies have demonstrated that UC patients have an altered gut gas metabolism.

Areas covered: In this review, we integrate gut gas metabolism advances in UC and discuss intestinal gases' clinical values as new biomarkers or therapeutic targets for UC, providing the foundation for further research. Literature regarding gut gas metabolism and its significance in UC from inception to October 2023 was searched on the MEDLINE database and references from relevant articles were investigated.

Expert opinion: Depending on their type, concentration, and volume, gut gases can induce or alleviate clinical symptoms and regulate intestinal motility, inflammatory responses, immune function, and oxidative stress, significantly impacting UC. Gut gases may function as new biomarkers and provide potential diagnostic or therapeutic targets for UC.

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溃疡性结肠炎肠道气体代谢的最新进展。

简介溃疡性结肠炎（UC）是一种慢性、非特异性肠道炎症性疾病。肠道微生物群对溃疡性结肠炎的发生和发展至关重要。肠道气体通过细菌发酵或化学作用产生，可显示肠道微生物群的改变、细胞代谢异常和炎症反应。最近的研究表明，UC 患者的肠道气体代谢发生了改变：在这篇综述中，我们整合了 UC 肠道气体代谢的研究进展，并讨论了肠道气体作为 UC 新生物标记物或治疗靶点的临床价值，为进一步的研究奠定了基础。在 MEDLINE 数据库中检索了从开始到 2023 年 10 月有关肠道气体代谢及其在 UC 中重要性的文献，并调查了相关文章的参考文献：肠道气体可诱发或减轻临床症状，并调节肠道蠕动、炎症反应、免疫功能和氧化应激，对 UC 产生重大影响，这取决于肠道气体的类型、浓度和数量。肠道气体可作为新的生物标记物，为 UC 提供潜在的诊断或治疗目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.80

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.