The use of injectable subcutaneous terbutaline and topical nitroglycerin ointment in the treatment of peripheral vasopressor extravasation in 3 dogs

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES Journal of veterinary emergency and critical care Pub Date : 2024-06-20 DOI:10.1111/vec.13393

Chele N. Lathroum MS, DVM, DACVECC, Hernan Lizardo Angulo Bracho MVZ, Esp, DVM, Kayla M. Alessandrino BVMS, Julie M. Walker DVM, DACVECC

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Abstract

Objective

To describe the clinical course and treatment of 3 dogs with peripheral vasopressor extravasation.

Case Series Summary

Although vasopressor extravasation (VE) is a well-documented complication in human medicine, literature describing VE and its management in veterinary patients is sparse. VE increases patient morbidity by causing local tissue injury and necrosis. The gold standard treatment for VE, phentolamine, has been periodically limited in supply in human medicine and is not consistently available for use in veterinary medicine. An alternative protocol proposed for use in people with VE combines topical nitroglycerin application with subcutaneous terbutaline infiltration. In this report, a treatment protocol utilizing these therapies was used to treat 3 dogs with VE and secondary tissue injury.

New or Unique Information Provided

This report describes 3 cases of VE-induced tissue injury in dogs. In addition, this report describes the use of perivascular terbutaline infiltration and topical nitroglycerin application as therapeutic management for VE in dogs.

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在 3 只狗身上使用皮下注射特布他林和局部硝酸甘油软膏治疗外周血管外渗。

目的：描述 3 只患有外周血管加压外渗的狗的临床过程和治疗方法：病例系列摘要：虽然血管加压素外渗（VE）是人类医学中一种证据确凿的并发症，但描述兽医患者血管加压素外渗及其治疗的文献却很少。VE会造成局部组织损伤和坏死，从而增加患者的发病率。酚妥拉明是治疗VE的金标准，但在人类医学中的供应定期受到限制，在兽医学中也无法持续使用。建议用于 VE 患者的替代方案是将硝酸甘油局部应用与特布他林皮下浸润相结合。在本报告中，利用这些疗法的治疗方案治疗了 3 只患有 VE 和继发性组织损伤的狗：本报告描述了 3 例 VE 引起的犬组织损伤。此外，该报告还介绍了使用血管周围特布他林浸润和局部硝酸甘油来治疗犬 VE 的方法。

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来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.

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