Unraveling the intricacies of glycosaminoglycan biosynthesis: Decoding the molecular symphony in understanding complex polysaccharide assembly

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology advances Pub Date : 2024-07-20 DOI:10.1016/j.biotechadv.2024.108416
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Abstract

Glycosaminoglycans (GAGs) are extensively utilized in clinical, cosmetic, and healthcare field, as well as in the treatment of thrombosis, osteoarthritis, rheumatism, and cancer. The biological production of GAGs is a strategy that has garnered significant attention due to its numerous advantages over traditional preparation methods. In this review, we embark on a journey to decode the intricate molecular symphony that orchestrates the biosynthesis of glycosaminoglycans. By unraveling the complex interplay of related enzymes and thorough excavation of the intricate metabolic cascades involved, GAGs chain aggregation and transportation, which efficiently and controllably modulate GAGs sulfation patterns involved in biosynthetic pathway, we endeavor to offer a thorough comprehension of how these remarkable GAGs are intricately assembled and pushes the boundaries of our understanding in GAGs biosynthesis.

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揭开糖胺聚糖生物合成的神秘面纱:解码分子交响乐,了解复杂多糖的组装。
糖胺聚糖(GAGs)被广泛应用于临床、美容和保健领域,以及血栓、骨关节炎、风湿病和癌症的治疗中。与传统制备方法相比,生物法生产 GAGs 具有诸多优势,因此备受关注。在这篇综述中,我们将踏上解密糖胺聚糖生物合成过程中错综复杂的分子交响乐之旅。通过揭示相关酶的复杂相互作用,深入挖掘其中涉及的错综复杂的代谢级联、GAGs 链的聚集和运输,从而有效、可控地调节生物合成途径中涉及的 GAGs 硫酸化模式,我们致力于提供对这些非凡的 GAGs 如何错综复杂地组装的透彻理解,并推动我们对 GAGs 生物合成的认识不断向前发展。
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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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