Recent advances in treating constipation in children.

IF 3.8 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Expert Review of Gastroenterology & Hepatology Pub Date : 2024-07-01 Epub Date: 2024-07-25 DOI:10.1080/17474124.2024.2383636

Sharon Wolfson, Miguel Saps

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Abstract

Introduction: Functional constipation (FC) is a common childhood condition, diagnosed via the Rome IV criteria. Standard therapy includes lifestyle and dietary modification followed by initiation of osmotic laxative therapy. About 30% of children continue to experience symptoms related to FC despite appropriate management. New pharmacologic, surgical, and neuromodulatory therapies for FC are now available for use in adult and pediatric populations. In 2023, the first pharmacologic agent, linaclotide, obtained FDA approval for treatment of FC in children 6-17 years old.

Areas covered: This article reviews current and emerging pharmacologic, surgical, and neuromodulation therapies for the management of FC in pediatric patients. Efficacy and safety data regarding each of these modalities was reviewed and discussed.

Expert opinion: Advancements in therapeutics available for the management of FC necessitate further investigation on safety and efficacy in pediatric populations. Careful consideration should be taken in choosing an available treatment with limited pediatric evidence as adult and pediatric FC have different underlying pathophysiology and require a different therapeutic approach. Standardization of methodology and pediatric endpoints are needed to optimize ability to compare efficacy of different treatments. We predict the future of pediatric FC management will include a personalized approach to care, resulting in improved outcomes.

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治疗儿童便秘的最新进展。

简介功能性便秘（FC）是一种常见的儿童疾病，根据罗马IV标准进行诊断。标准疗法包括调整生活方式和饮食，然后开始渗透性通便疗法。尽管采取了适当的治疗措施，但仍有约 30% 的儿童持续出现与 FC 相关的症状。目前，针对 FC 的新型药物、手术和神经调节疗法已可用于成人和儿童群体。2023 年，第一种药理药物利那洛肽获得美国食品及药物管理局批准，用于治疗 6-17 岁儿童的 FC：本文回顾了目前和新兴的用于治疗儿童 FC 的药物、手术和神经调节疗法。专家意见：专家意见：随着治疗 FC 的疗法不断发展，有必要进一步研究其在儿科人群中的安全性和有效性。在选择儿科证据有限的现有治疗方法时应慎重考虑，因为成人和儿科 FC 具有不同的潜在病理生理学，需要不同的治疗方法。需要对方法和儿科终点进行标准化，以优化比较不同治疗方法疗效的能力。我们预测，儿科 FC 管理的未来将包括个性化的护理方法，从而改善疗效。

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来源期刊

Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.80

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.