Immunological roads diverged: mapping tuberculosis outcomes in mice.

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Microbiology Pub Date : 2024-07-20 DOI:10.1016/j.tim.2024.06.007
Rachel K Meade, Clare M Smith
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引用次数: 0

Abstract

The journey from phenotypic observation to causal genetic mechanism is a long and challenging road. For pathogens like Mycobacterium tuberculosis (Mtb), which causes tuberculosis (TB), host-pathogen coevolution has spanned millennia, costing millions of human lives. Mammalian models can systematically recapitulate host genetic variation, producing a spectrum of disease outcomes. Leveraging genome sequences and deep phenotyping data from infected mouse genetic reference populations (GRPs), quantitative trait locus (QTL) mapping approaches have successfully identified host genomic regions associated with TB phenotypes. Here, we review the ongoing optimization of QTL mapping study design alongside advances in mouse GRPs. These next-generation resources and approaches have enabled identification of novel host-pathogen interactions governing one of the most prevalent infectious diseases in the world today.

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免疫学道路上的分歧:绘制小鼠结核病结果图。
从表型观察到因果遗传机制是一条漫长而充满挑战的道路。对于结核分枝杆菌(Mtb)等导致肺结核(TB)的病原体来说,宿主与病原体的共同进化跨越了数千年,夺走了数百万人的生命。哺乳动物模型可以系统地再现宿主基因变异,产生一系列疾病结果。利用基因组序列和来自受感染小鼠遗传参考群体(GRPs)的深度表型数据,定量性状位点(QTL)绘图方法已成功鉴定出与结核病表型相关的宿主基因组区域。在此,我们回顾了 QTL 图谱研究设计的不断优化以及小鼠 GRPs 的进步。这些下一代资源和方法使我们能够鉴定新的宿主-病原体相互作用,从而控制当今世界上最流行的传染病之一。
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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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