Exploring the potential of chitin and chitosan in nanobiocomposites for fungal immunological detection and antifungal action

IF 2.4 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Carbohydrate Research Pub Date : 2024-07-19 DOI:10.1016/j.carres.2024.109220

Manuela Gómez-Gaviria, Héctor M. Mora-Montes

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Abstract

Chitin is a polymer of N-acetylglucosamine and an essential component of the fungal cell wall. Chitosan is the deacetylated form of chitin and is also important for maintaining the integrity of this structure. Both polysaccharides are widely distributed in nature and have been shown to have a variety of applications in biomedicine, including their potential in immune sensing and as potential antifungal agents. In addition, chitin has been reported to play an important role in the pathogen-host interaction, involving innate and adaptive immune responses. This paper will explore the role of chitin and chitosan when incorporated into nanobiocomposites to improve their efficacy in detecting fungi of medical interest and inhibiting their growth. Potential applications in diagnostic and therapeutic medicine will be discussed, highlighting their promise in the development of more sensitive and effective tools for the early diagnosis of fungal infections. This review aims to highlight the importance of the convergence of nanotechnology and biology in addressing public health challenges.

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探索甲壳素和壳聚糖纳米生物复合材料在真菌免疫学检测和抗真菌作用方面的潜力

甲壳素是一种 N-乙酰葡糖胺聚合物，是真菌细胞壁的重要组成部分。壳聚糖是甲壳素的脱乙酰形式，对于保持这种结构的完整性也很重要。这两种多糖在自然界中分布广泛，已被证明在生物医学中具有多种用途，包括潜在的免疫传感和潜在的抗真菌剂。此外，有报道称几丁质在病原体与宿主的相互作用中扮演重要角色，涉及先天性免疫反应和适应性免疫反应。本文将探讨几丁质和壳聚糖在纳米生物复合材料中的作用，以提高其检测医学真菌和抑制真菌生长的功效。文章将讨论纳米生物复合材料在诊断和治疗医学中的潜在应用，强调它们在开发更灵敏、更有效的真菌感染早期诊断工具方面的前景。本综述旨在强调纳米技术与生物学融合在应对公共卫生挑战方面的重要性。

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来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".

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