Modified Planar Sensors for Determination of Cefepime

IF 0.9 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY Inorganic Materials Pub Date : 2024-07-19 DOI:10.1134/s0020168524700018

E. G. Kulapina, R. K. Mursalov, O. I. Kulapina, V. D. Ankina, E. N. Cherdakova

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Abstract

Planar screen-printed potentiometric sensors sensitive to cefepime, a fourth-generation cephalosporine antibiotic, have been developed. Cefepime is an amphoteric antibiotic with the carboxyl and aminothiazole groups, which exists as a cation in strongly acidic media, a zwitterion in weakly acidic and neutral media, and an anion in alkaline media. The interval of pH 1.5–2.0 for obtaining the cationic electrode functions for the determination of cefepime has been established. The cefepime–tetraphenylborate associates have been used as electrode-active components; the optimum content of the latter for planar sensors is 2–3%. For the unmodified cefepime sensors, the electrode functions are linear in the range of 1 × 10^–5–1 × 10^–2 M, the angular coefficients are 50 ± 2 mV/pC, and the response time is 20 s. The role of the modifier, ZnO nanoparticles, in improving the electroanalytical properties of the sensors is shown. The introduction of a binary mixture of zinc oxide and cetylpyridinium chloride into carbon-based ink reduces the cefepime detection limit (1 × 10^–6 M) and increases the angular coefficient (58 ± 1 mV/pC), the interval of linearity of the electrode functions (1 × 10^–6–1 × 10^–2 M), and the sensor response time (17 s). A surfactant used as an electrode surface co-modifier stabilizes the nanoparticle dispersion. The use of the modified screen-printed sensors for the cefepime determination in medicinal and biological media, in particular, in saliva, is demonstrated.

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用于检测头孢吡肟的改进型平面传感器

摘要开发了对第四代头孢菌素抗生素头孢吡肟敏感的平面丝网印刷电位传感器。头孢吡肟是一种带有羧基和氨基噻唑基的两性抗生素，在强酸性介质中以阳离子形式存在，在弱酸性和中性介质中以齐聚物形式存在，在碱性介质中以阴离子形式存在。已确定在测定头孢吡肟时获得阳离子电极功能的 pH 值范围为 1.5-2.0。头孢吡肟-四苯基硼酸酯类化合物被用作电极活性成分；后者在平面传感器中的最佳含量为 2-3%。对于未经改性的头孢吡肟传感器，电极功能在 1 × 10-5-1 × 10-2 M 的范围内呈线性，角度系数为 50 ± 2 mV/pC，响应时间为 20 秒。在碳基墨水中引入氧化锌和氯化十六烷基吡啶的二元混合物可降低头孢吡肟的检测限（1 × 10-6 M），增加角系数（58 ± 1 mV/pC）、电极函数的线性间隔（1 × 10-6-1 × 10-2 M）和传感器响应时间（17 秒）。用作电极表面辅助改性剂的表面活性剂可稳定纳米粒子的分散。实验证明，改性丝网印刷传感器可用于测定药物和生物介质，特别是唾液中的头孢吡肟。

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来源期刊

Inorganic Materials 工程技术-材料科学：综合

CiteScore

1.40

自引率

25.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Inorganic Materials is a journal that publishes reviews and original articles devoted to chemistry, physics, and applications of various inorganic materials including high-purity substances and materials. The journal discusses phase equilibria, including P–T–X diagrams, and the fundamentals of inorganic materials science, which determines preparatory conditions for compounds of various compositions with specified deviations from stoichiometry. Inorganic Materials is a multidisciplinary journal covering all classes of inorganic materials. The journal welcomes manuscripts from all countries in the English or Russian language.