Facile synthesis, characterization, and in vitro biocompatibility of free-standing titania hollow microtubes

IF 1.8 4区材料科学 Q2 MATERIALS SCIENCE, CERAMICS International Journal of Applied Ceramic Technology Pub Date : 2024-07-17 DOI:10.1111/ijac.14858

Yixuan Wang, Fenghao Zhang, Song Chen, Akiyoshi Osaka, Weiyi Chen

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Abstract

Titania nanotube (NT) arrays have been widely used as cell-supporting matrices. However, cells are always seeded on the porous surface of the NT array and have very limited interactions with each individual NT in the array. In this study, titania hollow microtubes (HMTs) were synthesized via a gelatin-template sol-gel route and then utilized as free-standing cell-supporting matrices for the first time. The resultant titania HMTs were studied by field emission scanning electron microscopy, energy-dispersed spectroscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy. Each HMT was composed of rutile-type titania nanoparticles with diameters of 50–100 nm and a diameter of 50–100 µm. The results from a leaching liquor assay demonstrated good biocompatibility of titania HMTs. Each HMT has been demonstrated to independently support the adhesion and proliferation of osteoblast MC3T3-E1 cells. For comparison, titania NT arrays, not independent titania NT, only supported the adhesion of cells on their porous surface. Thus, the resultant titania HMTs are applicable to free-standing and biocompatible cell-supporting matrices.

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独立二氧化钛空心微管的简易合成、表征和体外生物相容性

钛纳米管（NT）阵列已被广泛用作细胞支持基质。然而，细胞总是种在纳米管阵列的多孔表面上，与阵列中每个纳米管的相互作用非常有限。本研究通过明胶-模板溶胶-凝胶路线合成了二氧化钛空心微管（HMT），并首次将其用作独立的细胞支持基质。研究人员利用场发射扫描电子显微镜、能量色散光谱、X 射线衍射和傅立叶变换红外光谱对所得到的二氧化钛 HMT 进行了研究。每种 HMT 都由直径为 50-100 纳米和 50-100 微米的金红石型二氧化钛纳米颗粒组成。浸出液检测结果表明，二氧化钛 HMT 具有良好的生物相容性。每个 HMT 都能独立支持成骨细胞 MC3T3-E1 的粘附和增殖。相比之下，非独立的二氧化钛 NT 阵列只能支持细胞在其多孔表面的粘附。因此，由此产生的二氧化钛 HMT 适用于独立的生物相容性细胞支持基质。

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来源期刊

International Journal of Applied Ceramic Technology 工程技术-材料科学：硅酸盐

CiteScore

3.90

自引率

9.50%

发文量

280

审稿时长

4.5 months

期刊介绍： The International Journal of Applied Ceramic Technology publishes cutting edge applied research and development work focused on commercialization of engineered ceramics, products and processes. The publication also explores the barriers to commercialization, design and testing, environmental health issues, international standardization activities, databases, and cost models. Designed to get high quality information to end-users quickly, the peer process is led by an editorial board of experts from industry, government, and universities. Each issue focuses on a high-interest, high-impact topic plus includes a range of papers detailing applications of ceramics. Papers on all aspects of applied ceramics are welcome including those in the following areas: Nanotechnology applications; Ceramic Armor; Ceramic and Technology for Energy Applications (e.g., Fuel Cells, Batteries, Solar, Thermoelectric, and HT Superconductors); Ceramic Matrix Composites; Functional Materials; Thermal and Environmental Barrier Coatings; Bioceramic Applications; Green Manufacturing; Ceramic Processing; Glass Technology; Fiber optics; Ceramics in Environmental Applications; Ceramics in Electronic, Photonic and Magnetic Applications;