{"title":"Fabrication of silver-decorated zinc oxide nanowire sensor in microchannels for surface-enhanced Raman spectroscopy","authors":"Andrew L. Cook, Todd D. Giorgio","doi":"10.1117/1.jnp.18.036002","DOIUrl":null,"url":null,"abstract":"Surface-enhanced Raman spectroscopy (SERS) performed in microfluidic channels offers multiple benefits to the sensitive and reliable detection of dilute analytes while utilizing the advantages of microfluidics, including small samples, high throughput, and portability. Physical deposition of metallic nanoparticles by techniques, such as electron beam deposition, results in dense populations of nanoparticles and hotspots between nanoparticles for sensitive detection. However, not only do physically deposited SERS-active surfaces necessitate additional steps during device fabrication, but also surface fabrication is itself complicated by the constraints imposed by the microfluidic channel. Our work demonstrates a robust approach to the physical fabrication of an SERS-active substrates inside a poly(dimethylsiloxane) (PDMS) microfluidic channel. Direct growth of zinc oxide nanowires inside the PDMS channel and e-beam deposition of silver to coat the nanowires was performed before bonding PDMS to glass. This process enables label-free SERS sensing of micromolar crystal violet and melamine with minimal spectral interference from the PDMS-based channel.","PeriodicalId":16449,"journal":{"name":"Journal of Nanophotonics","volume":"47 1","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanophotonics","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1117/1.jnp.18.036002","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NANOSCIENCE & NANOTECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Surface-enhanced Raman spectroscopy (SERS) performed in microfluidic channels offers multiple benefits to the sensitive and reliable detection of dilute analytes while utilizing the advantages of microfluidics, including small samples, high throughput, and portability. Physical deposition of metallic nanoparticles by techniques, such as electron beam deposition, results in dense populations of nanoparticles and hotspots between nanoparticles for sensitive detection. However, not only do physically deposited SERS-active surfaces necessitate additional steps during device fabrication, but also surface fabrication is itself complicated by the constraints imposed by the microfluidic channel. Our work demonstrates a robust approach to the physical fabrication of an SERS-active substrates inside a poly(dimethylsiloxane) (PDMS) microfluidic channel. Direct growth of zinc oxide nanowires inside the PDMS channel and e-beam deposition of silver to coat the nanowires was performed before bonding PDMS to glass. This process enables label-free SERS sensing of micromolar crystal violet and melamine with minimal spectral interference from the PDMS-based channel.
期刊介绍:
The Journal of Nanophotonics publishes peer-reviewed papers focusing on the fabrication and application of nanostructures that facilitate the generation, propagation, manipulation, and detection of light from the infrared to the ultraviolet regimes.