Low-cost microfabrication methodology for microfluidic chips using 3D printer and replica molding techniques for biosensors

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION Microfluidics and Nanofluidics Pub Date : 2024-07-18 DOI:10.1007/s10404-024-02745-9
Tamara Jennifer Crisóstomo-Rodríguez, Vania Denis Alonso-Santacruz, Luis Alfonso Villa-Vargas, Marco Antonio Ramírez-Salinas, Miguel Ángel Alemán-Arce, Verónica Iraís Solís-Tinoco
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Abstract

Microfluidics is an area that allows the design and construction of microchips. The most common fabrication of these chips is expensive and difficult to access, requiring a specialized laboratory, with instruments that need to be monitored by experienced technicians and high-cost materials, then new techniques are sought to facilitate their production. Here, we present a fabrication methodology that combines the 3D printer resolution, and the polydimethylsiloxane flexibility to create hydrophobic and biocompatible microfluidics chips which are connected to a microfluidic control system. Transparent, and leak-free polydimethylsiloxane microchips were achieved with a width and a height of 250 µm. This strategy allows to produce at least, 20 chips using the same resin mold. The pressure at which the chip can work is from 2.4 kPa to 124 kPa. This work provides a low-cost alternative for academic and research groups to create their own microfluidic systems and use the microfluidic advantages in all types of applications including biosensor building, studies in medicine, biology, nanoscience, environmental technology, chemistry, etc., since it allows a controlled manipulation of one or more fluids in a certain area where a sensor can be placed, generate a reaction, among others.

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利用 3D 打印机和生物传感器复制成型技术实现微流控芯片的低成本微制造方法
微流体技术是一个可以设计和制造微型芯片的领域。这些芯片最常见的制造方法既昂贵又难以获得,需要专门的实验室、需要有经验的技术人员监控的仪器和高成本的材料,因此人们寻求新技术来促进其生产。在这里,我们介绍一种结合了三维打印机分辨率和聚二甲基硅氧烷柔韧性的制造方法,用于制造疏水性和生物相容性微流体芯片,并将其连接到微流体控制系统。透明无泄漏聚二甲基硅氧烷微芯片的宽度和高度均为 250 微米。通过这种方法,使用同一个树脂模具至少可以生产 20 个芯片。芯片的工作压力从 2.4 千帕到 124 千帕不等。这项工作为学术和研究团体提供了一个低成本的替代方案,使他们能够创建自己的微流体系统,并将微流体的优势用于各类应用,包括生物传感器构建、医学研究、生物学、纳米科学、环境技术、化学等,因为它允许在一定区域内对一种或多种流体进行可控操作,在该区域内可以放置传感器,产生反应等。
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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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